Prevalence and factors associated with non-adherence to antiepileptic drugs among children with epilepsy in Jos, Nigeria

Ejeliogu, Emeka; Courage, A.

doi:10.4314/njp.v47i3.8

Cited by 9 publications

(27 citation statements)

References 24 publications

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“…As a result, the barriers to patients adhering to their treatment should be investigated in depth in order to prevent poor treatment outcomes. 3 …”

Section: Introductionmentioning

confidence: 99%

“…Epilepsy is a neurologic illness characterized by frequent seizures that affects around 50 million individuals worldwide, with more than three-quarters of them living in poor nations. [1][2][3] Epilepsy affects 64 people out of every 100,000 people in Ethiopia. 2 The degree to which a patient's conduct matches to a health professional's advice is referred to as medication adherence.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, the barriers to patients adhering to their treatment should be investigated in depth in order to prevent poor treatment outcomes. 3 Noncompliance may result in seizure control failure, hospitalization, increased health-care costs, and a lower quality of life. 3,8,9 Aside from that, the death rate is higher as a result of pharmaceutical therapy issues.…”

Section: Introductionmentioning

confidence: 99%

“…3 Noncompliance may result in seizure control failure, hospitalization, increased health-care costs, and a lower quality of life. 3,8,9 Aside from that, the death rate is higher as a result of pharmaceutical therapy issues. 9,10 As a result, AED nonadherence is one of the most common causes of epilepsy treatment gaps, and maintaining anti-epileptic medication adherence is critical for achieving the best therapeutic health results.…”

Section: Introductionmentioning

confidence: 99%

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Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Bekele¹

2022

PPA

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Background Non-adherence to anti-epileptic drugs (AEDs) was the most common drug therapy issue that hampered epileptic patients’ treatment success. As a result, the barriers to patients adhering to their treatment should be investigated in depth in order to prevent poor treatment outcomes. Methods A hospital-based cross-sectional study was conducted on epileptic patients who had followed up at Mettu Karl Comprehensive Specialized Hospital (MKCSH). Data collection was done through patient interview and medical charts review. Hill-Bone Compliance to High Blood Pressure Therapy Scale was used to measure medication adherence. The data were analyzed using SPSS version 23 after data were entered by Epi Info7.2.1. The multivariable logistic regressions were utilized and P < 0.05 was used to declare association. Results Over the study period, more than half of the participants 172 (57.7%) were males, and the median age of participants was 29 years. The magnitude of non-adherence to ant-epileptic drugs (AEDs) was 120 (40.27%). The results of multivariable analysis revealed that patients who had experienced the medication side effects, adjusted odds ratio (AOR) = 2.199; 95% CI: 1.21, 4.00, P = 0.010, a poly-pharmacy, adjusted odds ratio (AOR) = 5.166; 95% CI: 2.63, 10.14, P = <0.001 and the presence of a co-morbidity, adjusted odds ratio (AOR) =3.70; 95% CI: 2.058, 6.65, P = <0.001 were the predictors of medication non-adherence. Conclusion The magnitude of non-adherences to AEDs was found to be high. Phenobarbitone was the most prescribed AEDs. The number of medications taken by the patients, the presence of co-morbidity and the occurrence of medication side effects had a significant association with non-adherence to AEDs. Therefore, the pharmaceutical care in general and drug information services in particular should be established to enhance medication adherence in our study area.

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“…As a result, the barriers to patients adhering to their treatment should be investigated in depth in order to prevent poor treatment outcomes. 3 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Bekele¹

2022

PPA

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“…Pill burden is particularly a problem in children and adolescents and refusal to take drugs is worse with increasing number of medications. Poly-therapy is more likely to be associated with drug toxicity [ 12 ]. Nearly two third (108, 63.5%) of our study participants were on mono-therapy (similar to study done in Nigeria, 59.3%) [ 12 ], from this ‘Phenytoin only’ accounted for nearly half (82, 48.2%) of cases; from those (those on mono-therapy) more than half of them were adherent to their medication(s) but mode of therapy was not associated with adherence status to ASMs in this study.…”

Section: Discussionmentioning

confidence: 99%

Adherence to anti-seizure medications and associated factors among children with epilepsy at tertiary Hospital in Southwest Ethiopia: a cross-sectional study

et al. 2022

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Background Childhood epilepsy causes a tremendous burden for the child, the family, society as well as the healthcare system. Adherence to anti-seizure medications (ASMs) is a key to treatment success. Poor adherence has been considered as one of the main causes of unsuccessful treatment for epilepsy and presents a potential ongoing challenge for achieving a key therapeutic goal of seizure control. Methods A facility-based cross-sectional study design was conducted among children with epilepsy attending the Pediatrics neurology follow up clinic of Jimma Medical Center from June- 21 to September- 20, 2021. Data were collected by using a semi-structured pre-tested questionnaire. Epidata version 3.1 and SPSS version 26.0 were used for data entry and analysis respectively. Descriptive statistics and binary logistic regression analysis were employed. Adjusted odds ratios were used to ascertain effect sizes for any association between the dependent and associated variables while significance level at p-value of < 0.05 was determined using 95% confidence intervals. Result A total of 170 children with epilepsy were included in this study. About 54.7% were male and 44.7% were in age range of 10–17 years. The overall adherence to anti-seizure medications was 54.1%. Those caregivers who were married [AOR = 7.46 (95% CI = 1.46, 38.20)], those children with controlled seizure status [AOR = 3.64 (95% CI = 1.51, 8.78)], those who got appropriate health care [AOR = 7.08(95% CI = 2.91, 17.24)], those caregivers who had good knowledge [AOR = 5.20(95% CI = 2.60,14.83)]; and positive attitude [AOR = 2.57 (95% CI = 1.06, 6.28)] towards epilepsy were significantly associated with adherence to anti-seizure medications. Conclusions More than half of the children/adolescents having epilepsy were adherent to their anti-seizure medication(s). Children’s adherence to anti- seizure medications was influenced by current marital status of the parents/caregivers, controlled seizure status, getting appropriate healthcare in the hospital, caregiver’s knowledge; and attitude towards epilepsy. More efforts are required to scale up the provision of client-centered service (provision of appropriate health care delivery, focus on quality of treatment and providing health education/counseling to improve caregivers’ knowledge and attitude towards epilepsy) to improve children’s adherence status to their medication(s) and seizure control status.

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Adherence to Anti-Epileptic Drugs and Self-reported Availability and Affordability of the Drugs in Addis Ababa, Ethiopia

Shawel,

Berhane

2024

Preprint

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BackgroundAnti-epileptic drugs (AEDs) are the primary therapeutic mode to control seizures in patients with epilepsy. Adherence to the medications is critical to achieving the goals of epilepsy therapy. However, the cost of the drugs and interrupted availability of AEDs contribute to non-adherence to epilepsy treatment. Therefore, this study aimed to assess AED adherence and its association with self-reported drug availability and affordability.ObjectiveTo assess whether self-reported availability and affordability of Antiepileptic drugs affect drug adherence among Epileptic Patients at Eka Kotebe General Hospital, Addis Ababa, Ethiopia, from January 2023 to March 2023.MethodsA hospital-based analytical cross-sectional study was conducted among 357 epileptic patients using the Consecutive sampling method in Eka Kotebe General Hospital, Addis Ababa, Ethiopia. AED adherence was measured using a self-report 3items questionnaire focusing on medication use patterns of patients from their last visit to the current visit. Statistical packages for Social Sciences 26.0 version statistical software cleaned, coded and analyzed the collected data. Binary logistic regression was fitted, and P-values less than 0.05 were considered to have statistical significance.ResultThe prevalence of AED adherence was 55.2% with 95% CI (50.1%; 60.2%). About two-thirds (61.3%) of patients in this study had limited access to the AEDs or could not afford the medications. Self-reported availability of AEDs (AOR=2.04, 95% CI=1.03, 4.03) was significantly associated with AED adherence. Self-reported affordability of AEDs was associated with AED adherence (COR=1.59, CI=1.04, 2.42, P-Value=0.031) in the Bivariate logistic regression analysis; however, when adjusted for other covariates in the multivariable logistic regression, no significant association was observed (p=0.730).Conclusion and RecommendationOnly about half of the epileptic patients adhered to AEDs at Eka Kotebe General Hospital. Self-reported availability of AEDs was an essential factor. Improving access to AEDs is critical to improving adherence and management of epilepsy.

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Prevalence and factors associated with non-adherence to antiepileptic drugs among children with epilepsy in Jos, Nigeria

Cited by 9 publications

References 24 publications

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Non-Adherence to Antiepileptic Drugs and Associated Factors among Epileptic Patients at Ambulatory Clinic of Southwestern Ethiopian Hospital: A Cross-Sectional Study

Adherence to anti-seizure medications and associated factors among children with epilepsy at tertiary Hospital in Southwest Ethiopia: a cross-sectional study

Adherence to Anti-Epileptic Drugs and Self-reported Availability and Affordability of the Drugs in Addis Ababa, Ethiopia

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