Prevalence and factors associated with diabetes mellitus among tuberculosis patients: a nationwide cohort

Costa, João Cordeiro da; Oliveira, Olena; Baía, Luís; Gaio, Rita; Correia-Neves, Margarida; Duarte, Raquel

doi:10.1183/13993003.00254-2016

Cited by 11 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Older age was identified as a risk factor for TB-DM comorbidity, in agreement with a recent systematic review [11] and with other European studies [15, 23, 25]. This association may reflect the current distribution of DM among the general population in Europe.…”

Section: Discussionsupporting

confidence: 89%

“…In our study, no association with HIV infection was identified. A negative association between being HIV-positive and DM prevalence among TB patients was reported by other studies also conducted in Europe—Italy [25], Spain [15, 17], and Portugal [23]. It has been suggested that the very strong association between HIV and TB may obscure the role of DM [6, 37]; however, a recent study concluded that DM may further increase the risk of developing TB among persons living with HIV [38].…”

Section: Discussionmentioning

confidence: 59%

“…People migrating from low- and middle-income countries may have a higher prevalence of DM compared with the native population, and also somehow higher than in persons from the same population who remain in their country of origin [32]. Nevertheless, opposite results (ie, lower risk of DM in foreign-born TB patients compared with authoctonous individuals or lower risk of TB in foreign-born DM patients compared with authoctonous) have been reported by previous studies conducted in Italy [24], Spain [15, 17], Portugal [23], and Japan [33].…”

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Burden and Characteristics of the Comorbidity Tuberculosis—Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study

Schepisi

Navarra

Gomez³

et al. 2018

Open Forum Infectious Diseases

View full text Add to dashboard Cite

BackgroundThe growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment outcomes. We aimed to analyze the prevalence of DM among TB patients and to describe the characteristics and clinical presentation of TB-DM patients in Europe.MethodsWe performed a cross-sectional survey on the prevalence of DM among consecutively diagnosed adult TB patients in 11 European TB referral centers located in France, Germany, Greece, Italy, Russia, Slovakia, Spain, and the United Kingdom over the period 2007–2015. We also selected DM-TB cases and TB only controls with a 1:3 ratio to perform a case-control analysis, including patients selected from the countries mentioned above plus Norway and Ukraine.ResultsAmong 3143 TB enrolled patients, DM prevalence overall was 10.7% and ranged from 4.4% in Greece to 28.5% in the United Kingdom. Patients’ median ages ranged from 36 to 49 years, and all centers had >60% males; the proportion of foreign-born patients varied widely across sites. In the case-control study, DM was independently associated with older age and, among older patients, with being foreign-born. Among patients with pulmonary involvement, cavities on chest imaging were more frequently observed among those with DM.ConclusionsDiabetes mellitus represents a challenge for TB control in Europe, especially in foreign-born and in elderly patients. Specific screening strategies should be evaluated.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Burden and Characteristics of the Comorbidity Tuberculosis—Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study

Schepisi

Navarra

Gomez³

et al. 2018

Open Forum Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Patients with DM were significantly older (p<0.001), with half being aged >60 years. 15 Higher incidence in males and significant age difference between TB with diabetes and TB without DM was also noted by Nissapatorn et al who studied 1,651 non HIV-infected patientsregistered for tuberculosis treatment. A total of 241 tuberculosis patients with diabetes (TBDM group) were included.…”

Section: Discussionmentioning

confidence: 66%

“Prevalence of Tb in Patients With Dm Under Revised National Tuberculosis Control Programme”

Hussain

Quadri

Prasad

2019

IJMBS

View full text Add to dashboard Cite

Background: DM has been shown to be an independent risk factor for TB, and there is evidence showing high DM prevalence in TB patients in studies mainly from the southern part of India. This strong association between DM and TB raises the question as to whether TB patients should be routinely screened for DM. Many studies have been conducted to establish the relation between TB and DM using fasting blood glucose as the parameter. Methods: 140 out of the 280 patients who were diagnosed as TB underwent blood tests for Fasting Blood Glucose and HbA1C along with the routine investigations like CBP, ESR, Chest X ray, ECG, Sputum examination. The data of patients with TB and DM and patients with only TB was compared. The data of pulmonary and extra pulmonary TB groups was compared. The data of sputum positive and sputum negative groups was compared. Student's t test was performed for normally distributed continuous variables and a p value was derived. Results: 38(27%) out of 140 patients had abnormal HbA1c i.e. > 6.5% having a strong association with male gender and age more than 45 years. The majority of the patients who had diabetes in this study, also had sputum positive TB(57%). This study showed a significant difference in mean age between the two groups of TB with diabetes(44.88 ± 5.721) and TB without DM(34.598 ± 10.56). Conclusion: There was a high prevalence of DM amongst the TB patients registered under RNTCP. Diabetes makes a substantial contribution to the burden of incident tuberculosis in India, and the association is particularly strong for the infectious form of tuberculosis. The current diabetes epidemic may lead to a resurgence of tuberculosis in endemic regions, especially in urban areas. This potentially carries a risk of global spread with serious implications for tuberculosis control.

show abstract

“…Apart from HIV infection, poor living and working conditions, which can facilitate TB transmission and risk factors that impair host's defense, like malnutrition, smoking, diabetes, alcohol abuse and indoor air pollution have been pointed out as major determinants. 29,30,31,32 Silicosis also increases the risk of TB by 2.8-39 times. 33,34 Silico-TB can be a challenging diagnosis and treatment must be longer.…”

Section: Discussionmentioning

confidence: 99%

Migration Flow and Its Impact on Tuberculosis Notification in Portugal

Dias

Gaio

Sousa

et al. 2018

Archivos de Bronconeumología (English Edition)

Self Cite

View full text Add to dashboard Cite

show abstract

Prevalence and factors associated with diabetes mellitus among tuberculosis patients: a nationwide cohort

Abstract: et al. A cost-benefit analysis of a proposed overseas refugee latent tuberculosis infection screening and treatment program.

Cited by 11 publications

References 14 publications

Burden and Characteristics of the Comorbidity Tuberculosis—Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study

Burden and Characteristics of the Comorbidity Tuberculosis—Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study

“Prevalence of Tb in Patients With Dm Under Revised National Tuberculosis Control Programme”

Migration Flow and Its Impact on Tuberculosis Notification in Portugal

Contact Info

Product

Resources

About