Prevalence and functioning of children with cerebral palsy in four areas of the United States in 2006: A report from the Autism and Developmental Disabilities Monitoring Network

Kirby, Russell S.; Wingate, Martha S.; Braun, Kim Van Naarden; Doernberg, Nancy; Arneson, Carrie L.; Benedict, Ruth E.; Mulvihill, Beverly A.; Durkin, Maureen S.; Fitzgerald, Robert T.; Maenner, Matthew J.; Patz, Jean A.; Yeargin‐Allsopp, Marshalyn

doi:10.1016/j.ridd.2010.12.042

Cited by 192 publications

(141 citation statements)

References 22 publications

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“…15 We have found 72% of the children with CND have GMFCS levels of I or II with somewhat more ability to ambulate than previous findings in children with CP in the general population both in Europe and North America. 29,30 In our study, children after CCS with CND presented with a higher rate of accompanying impairments including intellectual disability, autism, epilepsy, and vision impairment than those without CND. This supports other studies showing children with CP have a higher frequency of associated impairments than in the general population.…”

Section: Prediction Of Cndmentioning

confidence: 56%

“…This supports other studies showing children with CP have a higher frequency of associated impairments than in the general population. 29,30 We found that CCS survivors with CND, have a greater percentage of intellectual disability and autism but a lower rate of epilepsy compared with children with CP in the literature, 31,32 including less epilepsy and visual impairment than children described in the European Registry with postnatally acquired CP. 33 The frequency of permanent hearing impairment among those with CND and those without was similar in our study; this may have been associated to ototoxicity as previously reported.…”

Section: Prediction Of Cndmentioning

confidence: 76%

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Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Ricci¹,

Andersen

Joffe

et al. 2015

Pediatrics

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BACKGROUND AND OBJECTIVES: Little is known about chronic neuromotor disability (CND) including cerebral palsy and motor impairments after acquired brain injury in children surviving early complex cardiac surgery (CCS). We sought to determine the frequency and presentation of CND in this population while exploring potentially modifiable acute care predictors.METHODS: This prospective follow-up study included 549 children after CCS requiring cardiopulmonary bypass at #6 weeks of age. Groups included those with only 1 CCS, mostly biventricular CHD, and those with .1 CCS, predominantly single ventricle defects. At 4.5 years of age, 420 (94.6%) children received multidisciplinary assessment. Frequency of CND is given as percentage of assessed survivors. Predictors of CND were analyzed using multiple logistic regression analysis.RESULTS: CND occurred in 6% (95% confidence interval [CI] 3.7%-8.2%) of 4.5-year survivors; for 1 CCS, 4.2% (CI 2.3%-6.1%) and .1, 9.8% (CI 7%-12.6%). CND presentation showed: hemiparesis, 72%; spasticity, 80%; ambulation, 72%; intellectual disability, 44%; autism, 16%; epilepsy, 12%; permanent vision and hearing impairment, 12% and 8%, respectively. Overall, 32% of presumed causative events happened before first CCS. Independent odds ratio for CND are age (days) at first CCS, 1.08 (CI 1.04-1.12; P , .001); highest plasma lactate before first CCS (mmol/L), 1.13 (CI 1.03-1.23; P = 0.008); and .1 CCS, 3.57 (CI 1.48-8.9; P = .005).CONCLUSIONS: CND is not uncommon among CCS survivors. The frequency of associated disabilities characterized in this study informs pediatricians caring for this vulnerable population. Shortening the waiting period and reducing preoperative plasma lactate levels at first CCS may assist in reducing the frequency of CND. WHAT'S KNOWN ON THIS SUBJECT:Neurodevelopmental outcomes after cardiac surgery in early life provide critical information for understanding and improving care. Studies show these children are at risk for arterial ischemic stroke and acquired brain injury; further characterization of motor impairment is needed. WHAT THIS STUDY ADDS:This study focuses on the presence of chronic neuromotor disabilities including cerebral palsy and motor impairments after acquired brain injury in children surviving early complex cardiac surgery, providing information on the frequency, characteristics, and predictors that may assist in prevention.

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Section: Prediction Of Cndmentioning

confidence: 56%

Section: Prediction Of Cndmentioning

confidence: 76%

Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Ricci¹,

Andersen

Joffe

et al. 2015

Pediatrics

View full text Add to dashboard Cite

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“…With the exception of a higher proportion of Hispanic participants in this study, however, the demographics of the sample were similar to those reported in other areas of the United States (Kirby et al, 2011). We included no controls for comorbidities, spontaneous recovery, cognitive functioning, locus of brain lesions, or amount and type of therapy provided.…”

Section: Limitationsmentioning

confidence: 88%

Predicting the Effects of Cerebral Palsy Severity on Self-Care, Mobility, and Social Function

Phipps

Roberts

2012

The American Journal of Occupational Therapy

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In this retrospective, longitudinal cohort study, the Pediatric Evaluation of Disability Inventory was used to predict the effects of cerebral palsy (CP) on self-care, mobility, and social function for 2,768 children, adolescents, and young adults with CP. Multiple linear regression was used to predict functional performance and level of caregiver assistance and found that CP severity, as measured by the Gross Motor Function Classification System and the Manual Ability Classification System, had the strongest effect. More severe levels of gross motor and fine motor dysfunction resulted in lower levels of self-care, mobility, and social function and increased levels of caregiver assistance. This study provides critical evidence regarding the importance of CP severity as a predictor of self-care, mobility, and social function that can be tested in future research to improve therapy treatment planning, caregiver education, and clinical resource utilization.

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“…Moreover, we highlight novel evidence that implicates aberrant inflammation in CP as a potential mechanism linking both metabolic and cognitive dysregulation in a cyclical pattern. insulin resistance; spasticity; inflammation; extracellular matrix; fibrosis CEREBRAL PALSY (CP) IS OFTEN DESCRIBED as the most common physical disability of childhood, affecting between 2 and 3.6 per thousand live births (49,73,125). Over the past few years, there has been greater awareness of the unique problems facing children with CP as they transition to adulthood.…”

mentioning

confidence: 99%

Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy

Peterson

Gordon

Hurvitz

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

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Peterson MD, Gordon PM, Hurvitz EA, Burant CF. Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy. Am J Physiol Endocrinol Metab 303: E1085-E1093, 2012. First published August 21, 2012; doi:10.1152/ajpendo.00338.2012.-Cerebral palsy (CP) is caused by an insult to or malformation of the developing brain which affects motor control centers and causes alterations in growth, development, and overall health throughout the life span. In addition to the disruption in development caused by the primary neurological insult, CP is associated with exaggerated sedentary behaviors and a hallmark accelerated progression of muscle pathology compared with typically developing children and adults. Factors such as excess adipose tissue deposition and altered partitioning, insulin resistance, and chronic inflammation may increase the severity of muscle pathology throughout adulthood and lead to cardiometabolic disease risk and/or early mortality. We describe a model of exaggerated health risk represented in adults with CP and discuss the mechanisms and secondary consequences associated with chronic sedentary behavior, obesity, aging, and muscle spasticity. Moreover, we highlight novel evidence that implicates aberrant inflammation in CP as a potential mechanism linking both metabolic and cognitive dysregulation in a cyclical pattern. insulin resistance; spasticity; inflammation; extracellular matrix; fibrosis CEREBRAL PALSY (CP) IS OFTEN DESCRIBED as the most common physical disability of childhood, affecting between 2 and 3.6 per thousand live births (49,73,125). Over the past few years, there has been greater awareness of the unique problems facing children with CP as they transition to adulthood. CP is caused by a malformation or insult to the developing brain which affects motor control centers and causes alterations in growth, development, and overall health and function throughout the life span. Damage can occur during pregnancy, childbirth, or after birth up to about age three. Once established, the brain insult or structural problems do not appear to progress with time, but individuals with CP are subject to a number of secondary conditions that may interfere with important aspects of quality of life, such as independence, participation, and employment (11,64). These secondary complications can impede the monitoring of health risks as well as the diagnosis and treatment of medical complications.Unfortunately, at present there is a divergence between the basic research intended to uncover novel etiologic factors and treatments of CP and that which occurs at the translational level to understand secondary mechanisms or complications unique to this population. Clinical studies tend to focus on common symptoms, such as spasticity, gait disorders, pain, and fatigue, as well as the efficacy and outcomes of respective medical interventions. Conversely, most mechanistic research in this population is limited to prenatal and perinatal abnormalities and developmental neurology. Despite the significan...

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Prevalence and functioning of children with cerebral palsy in four areas of the United States in 2006: A report from the Autism and Developmental Disabilities Monitoring Network

Cited by 192 publications

References 22 publications

Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Chronic Neuromotor Disability After Complex Cardiac Surgery in Early Life

Predicting the Effects of Cerebral Palsy Severity on Self-Care, Mobility, and Social Function

Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy

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