Prevalence and incidence of systemic sclerosis: A systematic review and meta‐analysis

Abstract

Objective Systemic sclerosis (SSc) is a rare debilitating autoimmune disease of the connective tissue. This study aimed to assess the recent prevalence and incidence of SSc across the world. Methods Using a systematic search strategy, PubMed/MEDLINE and EMBASE were searched to identify relevant studies published between 2006 and 2016. Two reviewers independently evaluated studies for inclusion based on inclusion/exclusion criteria and performed data extraction. The review was conducted and reported following the Preferred Reporting Items for Systematic Review and Meta‐analysis (PRISMA) statement. The pooled prevalence of SSc was calculated by meta‐analysis using a random‐effects model. Results There were 1364 references retrieved using the initial searching strategy, and 20 epidemiological publications were selected for data extraction. The identified studies reported prevalence ranging from 3.8 per 100 000 in Taiwan to 50 per 100 000 in the USA. The prevalence was 23 per 100 000 (95% CI: 16‐29 per 100 000; 18 studies) in a pooled sample of 11 574 individuals. Incidence rate of SSc ranges from 0.77 per 100 000 person‐years in the Netherlands to 5.6 per 100 000 person‐years in the USA. SSc predominates in females with higher prevalence and incidence rates. It is important to note that different methodologies were used to derive these numbers so comparisons were made with caution. Conclusion This review provides an assessment of the current estimates of disease prevalence and incidence of SSc. The epidemiological burdens of SSc vary among different regions of the world. The epidemiological data need to be interpreted with caution considering the methodological differences in deriving these estimates.

Autoantibody profile in a cohort of Algerian patients with systemic sclerosis

“…Mots clés : auto-anticorps, associations cliniques, sclérodermie systémique, Algérie Systemic sclerosis (SSc) is an idiopathic systemic autoimmune rheumatic disease (SARD) characterized by vascular damage, immune dysregulation and massive deposits of collagen and other matrix substances in the skin and many internal organs, including the lungs, gastrointestinal tract, and kidneys [1][2][3]. The estimated annual incidence is of 0.77 to 5.6 per 100 000 adult inhabitants [4]. Women are affected more frequently than men with the female-to male ratios ranging from 4:1 to 14:1 [5].…”

Systemic Disease Associations with Disorders of Gut–Brain Interaction and Gastrointestinal Transit: A Review

“… 64 While the prevalence of systemic sclerosis varies by region, a recent meta-analysis estimated the pooled prevalence of systemic sclerosis as 23 per 100,000. 65 …”

TOP-N53: A Clinical Drug Candidate for the Treatment of Non-healing Wounds

“…The pooled prevalence of systemic sclerosis was reported as 23 cases per 100,000 individuals. [9] Digital ulcers are commonly associated with systemic sclerosis. These are defined as a denuded area of tissue with well-demarcat-ed borders, involving loss of both the dermis and epidermis often located at the fingertips.…”