Prevalence and predictors associated with severe pulmonary hypertension in COPD

Fekri, Mitra Samareh; Torabi, Mehdi; Shoul, Sara Azizi; Mirzaee, Moghaddameh

doi:10.1016/j.ajem.2017.08.014

Cited by 29 publications

(20 citation statements)

References 25 publications

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“…Chronic obstructive pulmonary disease (COPD) is a common chronic disease, and its incidence has gradually increased recently [ 1 ]. Pulmonary hypertension (PH) is a common complication of COPD, which seriously affects the prognosis and quality of life of patients [ 2 ]. Previous studies show that the occurrence of COPD is related to factors such as the living environment, air quality, smoking history, and genetic factors [ 3 ].…”

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confidence: 99%

Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism

et al. 2018

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Objective: To examine the association between brain natriuretic peptide (BNP) gene single nucleotide polymorphisms (SNPs) and chronic obstructive pulmonary disease (COPD) and COPD with pulmonary hypertension (PH) and to analyze its mechanism. Methods: The genotypes of BNP at the rs198389, rs6668352, and rs198388 loci in 339 patients with COPD (205 in the COPD/PH− group and 134 in the COPD/PH+ group) and 125 healthy subjects were detected by PCR/Sanger sequencing. The serum levels of BNP, fibrinogen (Fbg), and Apelin were measured in all subjects by ELISA. Results: The BNP rs198389 locus G allele, rs6668352 locus A allele, and 198388 locus T allele were high risk factors for COPD (P<0.001). Logistics regression analysis showed that BNP rs198389 locus G allele, rs6668352 locus A allele, and rs198388 locus T allele were high risk factors for PH in COPD patients (all P<0.001). The levels of the serum BNP and Fbg protein in the control group, COPD/PH− group, and COPD/PH+ group increased successively, and the expression levels of Apelin protein decreased successively (all P<0.001). The BNP and Fbg protein levels in the wild-type, heterozygote, and mutant homozygote in BNP rs198389, rs6668352, and rs198388 loci increased successively, and the serum Apelin protein levels decreased successively (all P<0.001). Conclusion: The polymorphisms of BNP at the rs198389, rs6668352, and rs198388 loci are associated with the occurrence of COPD and COPD with PH, and the occurrence may be related to the abnormal expression level of BNP, Fbg, and Apelin protein in the serum.

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confidence: 99%

Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism

et al. 2018

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“…These results suggested that PaCO 2 and HCO 3 − may be related to the severity of pulmonary artery pressure, in addition to NLR or SII. In accordance with this, Samareh conducted a cross-sectional study of 1078 patients with severe PH in COPD [33]. This study illustrated that various factors, such as hypoxia and hypopnea, play a major role in the severity of PH in these patients.…”

Section: Discussionmentioning

confidence: 86%

Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Zuo

Xie

et al. 2019

Analytical Cellular Pathology

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Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p < 0.05). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH (p < 0.05) in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.

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“…Transthoracic echocardiography is the imaging modality of choice to screen PHT 15–17 . More importantly, it may help to detect other frequently associated cardiac pathologies, such as left ventricle and valve dysfunctions, which can cause group 2 PHT.…”

Section: Discussionmentioning

confidence: 99%

The usefulness of subxiphoid view in the evaluation of acceleration time and pulmonary hypertension in ICU patients

et al. 2020

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Background Pulmonary hypertension (PHT) is very frequent in ICUs. Estimation of systolic pulmonary artery pressure (PASP) by using tricuspid regurgitation velocity (TRV) is impossible in 25% of patients. However, it may be possible to estimate PHT in these patients by obtaining subxiphoid imaging of short axis (SX‐SAX) and measuring pulmonary artery diameter (PAD) and right ventricular outflow tract (RVOT) acceleration time (AT). We first aimed to compare the values of AT and PAD measured at the parasternal short axis view (PSAX) and SX‐SAX and then to compare AT measurements obtained in the RVOT and pulmonary artery (PA) in ICU patients. Methods This prospective observational study was conducted in a 7‐bed ICU of a tertiary academic teaching hospital. Measurements of TRV, PAD, and AT in parasternal and subxiphoid SAX were obtained. AT was measured in RVOT and PA locations. We measured other echocardiographic signs of PHT to assess the probability of PHT in addition to TRV measurements. Results The study consisted of 61 patients. TRV was measured in 85% of the patients, and SX‐SAX was visualized in 78%. The probability of PHT was high (49%) in this study population. There were agreement and no proportional bias between the measurements of PAD and AT at both SX‐SAX and PSAX. Measurements of AT in the RVOT and PA were similar, as well. Conclusion These results suggested that measurements of AT in the PSAX and SX‐SAX and RVOT and PA were similar in the ICU patients.

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Prevalence and predictors associated with severe pulmonary hypertension in COPD

Cited by 29 publications

References 25 publications

Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism

Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism

Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

The usefulness of subxiphoid view in the evaluation of acceleration time and pulmonary hypertension in ICU patients

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