Prevalence and risk factors associated with fatal adverse drug reactions among patients admitted at a Spanish teaching hospital

Pardo-Cabello, Alfredo José; Luna, Juan de Dios; Jiménez, Francisco; Pozo, Esperanza Del; Cañas, Emilio Puche

doi:10.1016/j.ejim.2019.09.011

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Previous studies have reported that female sex, elderly age, number of medications, length of hospital stay, and admission to the intensive care unit and medical unit were significantly associated with ADRs. 21 29 30 31 33 52 53 Our study showed female sex, length of hospital stay, history of ADEs, and admission to surgical department were significantly associated with ADRs. Unlike previous studies suggesting that age is associated with ADRs, 33 52 our study showed that there was no difference in age between ADRs and non-ADRs.…”

Section: Discussionmentioning

confidence: 75%

“… 6 11 Most studies about ADRs occurring in inpatients were conducted in Western countries, and only a few studies were performed in Eastern countries. 5 6 7 8 11 21 22 23 24 25 26 27 28 29 30 31 The incidence and characteristics of ADRs may vary depending on the demographic characteristics of patients, including race, clinical practices, and prescription patterns of medical practitioners. Considering these aspects, our study reflects a relatively real ADR incidence of inpatients in Korea.…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with previous studies, female sex was one of the risk factors in our study owing to the administration of a greater number of drugs and presenting pharmacological reaction differences when compared with men. 31 …”

Section: Discussionmentioning

confidence: 99%

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Incidence and Economic Burden of Adverse Drug Reactions in Hospitalization: A Prospective Study in Korea

et al. 2023

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Background Adverse drug reactions (ADRs) are escalating, and their socioeconomic burden is increasing. However, large-scale prospective studies investigating ADRs during hospitalization are rare in Korea. We prospectively investigated the incidence, characteristics, and economic burden of ADRs in hospitalized patients based on electronic medical records (EMRs). Methods Among patients admitted to three hospitals from October 2016 to October 2017, 5,000 patients were randomly selected and prospectively observed during hospitalization. Research nurses monitored and detected patients who had symptoms, signs, or laboratory findings suspicious for ADRs using an EMR-based detection protocol. Next, allergy and ADR specialists reviewed the medical records to determine the relationship between adverse reactions and drugs. Cases in which a causal relationship was certain, probable/likely, or possible were included in the ADR cases. Clinically meaningful ADR cases or those leading to prolonged hospitalization were defined as significant ADRs. Results ADRs occurred in 510 (10.2%) patients. The mean length of hospital stay was approximately 5 days longer in patients with ADRs. Opioids accounted for the highest percentage of total ADRs. Significant ADRs were observed in 148 (3.0%) patients. Antibiotics accounted for the highest percentage of significant ADRs. Drug hypersensitivity reactions (DHRs) occurred in 88 (1.8%) patients. Antibiotics accounted for the highest percentage of DHRs. The average medical expenses for one day of hospitalization per patient were highest in significant ADRs, followed by non-significant ADRs, and non-ADRs. Conclusion ADRs in hospitalized patients are an important clinical issue, resulting in a substantial socioeconomic burden. EMR-based strategy could be a useful tool for ADR monitoring and early detection.

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