Prevalence and Risk Factors for Pulmonary Embolism in Pediatric Sickle Cell Disease: A National Administrative Database Study

Bala, Natasha; Stanek, Joseph; Rodriguez, Vilmarie; Villella, Anthony

doi:10.1080/08880018.2023.2166634

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…In the United States, there are an estimated 100,000 individuals with SCD 8 . SCD induces a hypercoagulable state that is associated with an increased risk of venous thromboembolism (VTE) and ischemic stroke 9–11 . However, bleeding complications can occur and have been described in children and adults with SCD 12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…8 SCD induces a hypercoagulable state that is associated with an increased risk of venous thromboembolism (VTE) and ischemic stroke. [9][10][11] However, bleeding complications can occur and have been described in children and adults with SCD. 12,13 Hariharan et al described an increased cumulative incidence of bleeding complications in adults with SCD by 40 years old, including HMB.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of menstrual health in adolescent and young adults with sickle cell disease

Notice,

Soffer,

Tickle

et al. 2023

Pediatric Blood & Cancer

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BackgroundSickle cell disease (SCD) is associated with hypercoagulability, but adults with SCD also have an increased incidence of bleeding including heavy menstrual bleeding (HMB). HMB is common among adolescent females, but the impact of HMB in pediatric SCD is unclear. The objectives of this study were to examine menstrual health status, knowledge, and quality of life (QOL).MethodsWe performed a single‐institutional multi‐clinic cross‐sectional study comprised of a five‐part survey in pediatric participants with SCD. The survey included the validated Menstrual Bleeding Questionnaire (MBQ) and Self‐administered Bleeding Assessment Tool (Self‐BAT).ResultsForty‐eight participants with a median age of 16 years (range: 12–21 years) completed the study. The mean age at onset of menarche was 13 ± 1.3 years. On the MBQ, 29% reported heavy/very heavy menstrual flow, 61% reported moderate or severe dysmenorrhea, and 96% had menses lasting less than 1 week. The Self‐BAT revealed that 42% of participants reported a history of HMB. Participants with severe dysmenorrhea or HMB had higher MBQ scores, corresponding to worse QOL. Despite this, less than 20% of participants had attempted any hormonal therapy for menstrual regulation. The odds of hormonal therapy utilization were comparable among participants on hydroxyurea versus not on hydroxyurea (odds ratio 1.58, 95% confidence interval [CI]: 0.33–7.56).ConclusionsThe prevalence of HMB and dysmenorrhea is high among adolescents and young women with SCD. Strategies that incorporate menstrual health assessment into routine medical care in this population would help address this important area of pediatric health.

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Section: Introductionmentioning

confidence: 99%