Prevalence and risk factors of gallbladder polypoid lesions in Chinese petrochemical employees

Mao, Yu; Mai, Yosuke; Li, Fujun; Zhang, Yanming; Hu, Ke-Min; Hong, Zhong-Li; Zhu, Zhongwei

doi:10.3748/wjg.v19.i27.4393

Cited by 25 publications

(41 citation statements)

References 24 publications

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“…Although the reported rate of malignancy GBP is only 3–8% [ 2 ], it is a common public health issue in many countries, affecting millions of people and the prevalence is continuing to increase [ 3 ]. The prevalence of GBP is reported in the range 0.3% to 9.5% worldwide, depending on the studied population and the study design [ 4 ]. Previous studies reported that compared to western populations, Asian populations (mainly Japanese, Korean and Chinese) have a higher GBP prevalence and appear to be at a higher risk of gallbladder cancer [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of GBP is reported in the range 0.3% to 9.5% worldwide, depending on the studied population and the study design [ 4 ]. Previous studies reported that compared to western populations, Asian populations (mainly Japanese, Korean and Chinese) have a higher GBP prevalence and appear to be at a higher risk of gallbladder cancer [ 4 – 7 ]. Recently, the prevalence of GBP is estimated from 4 to 7% in different areas of China [ 4 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic status and lifestyle factors associated with gallbladder polyps: a covariance structure analysis

Leng

Zhao

et al. 2018

BMC Gastroenterol

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BackgroundGallbladder Polyps (GBP) are highly prevalent in China; however, the etiology of GBP has not been clearly defined. This study explored the associations between lifestyle factors and GBP and whether it mediated by metabolic factors or not.MethodsA total of 487 newly diagnosed GBP cases and 502 healthy controls were involved in this study. A questionnaire was used to investigate the socio-demographic characteristics and lifestyle factors. Food Intake Frequencies Questionnaire was used to obtain the food intake frequencies of seven food categories. Blood was tested for lipid profiles, fasting blood glucose and blood urine acid. A Covariance Structure Analysis was used in the analysis to explore the possible pathways between socio-demographic characteristics, lifestyle factors, metabolic factor and GBP.ResultsThe Covariance Structure Analysis showed that a higher BMI and elevated triglyceride level mediated the association between age and GBP. Lifestyle factors (smoking and drinking) and higher intake frequencies of fatty food (meat and viscera) also linked to higher BMI and higher triglyceride level, respectively, which were associated with GBP.ConclusionIn conclusion, age and lifestyle factors might be indirectly related with GBP through BMI and the triglyceride pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolic status and lifestyle factors associated with gallbladder polyps: a covariance structure analysis

Leng

Zhao

et al. 2018

BMC Gastroenterol

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“…Such polypoid lesions have been observed in 1.4–12.3% of all GBs assessed by US, with the exact percentage depending on the population and study design. In Western countries, the prevalence of GBPs has been reported to be in the range of 1.4–6.7%, whereas in Eastern countries, mainly South Korea, Taiwan, China, and Japan, it has been reported to be 5.3–12.3% …”

Section: Introductionmentioning

confidence: 99%

“…In Western countries, the prevalence of GBPs has been reported to be in the range of 1.4-6.7%, [1][2][3] whereas in Eastern countries, mainly South Korea, Taiwan, China, and Japan, it has been reported to be 5.3-12.3%. [4][5][6][7][8][9] Recent studies have demonstrated an association between body fat and risk of GB cancer, [10][11][12] which has a poor prognosis due to its advanced stage at diagnosis. Larger polyps, especially those larger than 1 cm, are more likely to contain foci of invasive cancer, and some studies have suggested a correlation between the presence of GBPs and the risk of GB cancer.…”

Section: Introductionmentioning

confidence: 99%

Hepatic fat, not visceral fat, is associated with gallbladder polyps: A study of 2643 healthy subjects

Lim

Kim

Kang

et al. 2015

J of Gastro and Hepatol

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“…PLGs are not rare in the Chinese population, most of them are benign and asymptomatic, while a small fraction of PLGs has been diagnosed as gallbladder adenocarcinoma at advanced stage. BUS is the most economical, convenient and readily available modality with high sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 99%

Strategy for discriminating cholesterol and premalignancy in polypoid lesions of the gallbladder: a single‐centre, retrospective cohort study

Sun

Jiang

et al. 2018

ANZ Journal of Surgery

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Background: The present study aimed to assess the risk factors of cholesterol and premalignancy in polypoid lesions of the gallbladder (PLGs) and to establish an appropriate treatment strategy. Methods: Data from patients who underwent cholecystectomy at the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2011 and July 2017, were collected retrospectively. Results: A total of 1561 patients were included in the present study. The cohort comprised of 636 (40.7%) males and 925 (59.3%) females, with a mean age of 49.5 (range 16-88) years; 65.6% (1024/1561) demonstrated cholesterol lesions in this cohort, among which cholesterol polyps accounted for 81.0%. Age younger than 50 years and multiple number of polyps were found to be independent predictive variables for cholesterol lesions (odds ratio (OR) 3.461, 95% confidence interval (CI) 2.058-5.820, P < 0.001 and OR 3.321, 95% CI 1.988-5.547, P < 0.001, respectively). The presence of polyp growth was associated with premalignancy (OR 5.366, 95% CI 1.466-19.637, P = 0.011), and the presence of clinical symptoms indicated benign non-cholesterol lesions (OR 0.368, 95% CI 0.153-0.885, P = 0.026). Conclusion: In the case of patients ≥50 years old with single asymptomatic polyp, cholecystectomy was recommended if the polyp presented growth at a rate above 3-4 mm within 6 months. If not, trimonthly ultrasound follow up was recommended, and clinicians should carefully assess the risk factors for premalignancy in PLGs.

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Prevalence and risk factors of gallbladder polypoid lesions in Chinese petrochemical employees

Abstract: PLGs are not rare among Chinese petrochemical employees. Male gender, HBsAg positivity, and middle age are risk factors for developing PLGs.

Cited by 25 publications

References 24 publications

Metabolic status and lifestyle factors associated with gallbladder polyps: a covariance structure analysis

Metabolic status and lifestyle factors associated with gallbladder polyps: a covariance structure analysis

Hepatic fat, not visceral fat, is associated with gallbladder polyps: A study of 2643 healthy subjects

Strategy for discriminating cholesterol and premalignancy in polypoid lesions of the gallbladder: a single‐centre, retrospective cohort study

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