Prevalence and risk of occult cancer in stroke

Tybjerg, Anne Julie; Olsen, Tom Skyhøj; Andersen, Klaus Kaae

doi:10.1111/ane.13192

Cited by 8 publications

(16 citation statements)

References 20 publications

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“…Additionally, cancer influences the coagulation system and therefore may play a role in causing the ICH, and therefore ICH may even be a first symptom of an underlying malignancy. 24 , 25 In the Dutch hospital-based cohort, the percentage of vascular deaths was higher reaching 70%, whereas in the population-based cohort the percentage of vascular deaths was similar to our cohort with 29.8%. 6 , 21 Cause of death was not reported in the Finnish study.…”

Section: Discussionsupporting

confidence: 63%

Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

Verhoeven

Pasi

Casolla

et al. 2021

European Stroke Journal

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Introduction Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ICH survivors. Patients and methods We included consecutive patients aged 18–55 years from the Prognosis of Intracerebral Haemorrhage cohort (PITCH), a prospective observational cohort of patients admitted to Lille University Hospital (2004–2009), who survived at least 30 days after spontaneous ICH. We studied long-term mortality with Kaplan-Meier analyses, collected causes of death, performed uni-/multivariable Cox-regression analyses for the association of baseline characteristics with long-term mortality. Results Of 560 patients enrolled in the PITCH, 75 patients (75% men) met our inclusion criteria (median age 50 years, interquartile range [IQR] 44–53 years). During a median follow-up of 8.2 years (IQR 5.0–10.1), 26 patients died (35%), with a standardized mortality ratio of 13.0 (95% confidence interval [95% CI] 8.5–18.0) compared to peers from the general population. Causes of death were vascular in 7 (27%) patients, non-vascular in 13 (50%) and unknown in 6 (23%). Global cerebral atrophy (hazard ratio [HR] 3.0, 95% CI 1.1–8.6), modified Rankin Score >2 before ICH (HR 3.4, 95% CI 1.0–11.0), and excessive alcohol consumption (HR 3.3, 95% CI 1.1–10.2) were independently associated with long-term mortality. Discussion We found a 13-fold higher mortality risk for young ICH survivors compared to the general French population. Predictors of long-term mortality were pre-existing conditions, not ICH-characteristics. Conclusion Young ICH survivors remain at increased mortality risk of vascular and non-vascular death for years after ICH.

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Section: Discussionsupporting

confidence: 63%

Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

Verhoeven

Pasi

Casolla

et al. 2021

European Stroke Journal

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“…The registries and the descriptions of variables used for the analyses in this study have previously been presented in detail 1 . In brief, we included only patients with a first‐time stroke (ischemic or hemorrhagic).…”

Section: Methodsmentioning

confidence: 99%

“…Almost three percent of patients admitted with acute stroke in Denmark harbor occult cancer which will become manifest within a year after stroke. It is 50% more than in the general population without stroke 1 . The risk for harboring occult cancer in stroke patients, therefore, is a matter of concern.…”

Section: Introductionmentioning

confidence: 99%

Types of occult cancer in stroke and the relation to smoking

et al. 2020

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Almost three percent of patients admitted with acute stroke in Denmark harbor occult cancer which will become manifest within a year after stroke. It is 50% more than in the general population without stroke. 1 The risk for harboring occult cancer in stroke patients, therefore, is a matter of concern. It was recently shown that patients with newly diagnosed cancers had previously suffered a stroke twice as often if cancers were related to smoking (eg, cancers of the lung, colon, etc) while this was

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“…Various radio- and chemotherapeutic agents may affect the development and progression of cardiovascular disease ( Arthurs et al, 2016 ; Navi et al, 2015 ; Zöller et al, 2012 ; Zhang et al, 2021 ). Further, several studies have indicated a high prevalence of occult cancer in patients with cardiovascular disease and reported that it is important to identify cancer risk factors as it may aid in developing new and effective preventive strategies ( Corraini et al, 2018 ; Tybjerg, Skyhøj Olsen & Andersen, 2020 ; Wang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

Chen

Pan

et al. 2023

PeerJ

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Objective Coronary artery disease (CAD) and cancer are the two leading causes of death worldwide. Evidence suggests the existence of shared mechanisms for these two diseases. We aimed to conduct a systematic review and meta-analysis to investigateassociation between CAD and incident cancer risk. Methods We searched Cochrane, PubMed, and Embase from inception until October 20, 2021, without language restrictions. Observational cohort studies were used to investigate the association between CAD and incident cancer risk. Using random-effects models, the odds ratio (OR) and 95% confidence interval (CI) were calculated. We utilized subgroup and sensitivity analyses to determine the potential sources of heterogeneity and explore the association between CAD and specific cancers. This study was conducted under a pre-established, registered protocol on PROSPERO (CRD42022302507). Results We initially examined 8,533 articles, and included 14 cohort studies in our review, 11 of which were eligible for meta-analysis. Patients with CAD had significantly higher odds of cancer risk than those without CAD (OR = 1.15, 95% CI = [1.08–1.22], I2 = 66%). Subgroup analysis revealed that the incident cancer risk was significantly higher in both sexes and patients with CAD with or without myocardial infarction. Sensitivity analysis revealed that the risk remained higher in patients with CAD even after >1 year of follow-up (OR = 1.23, 95% CI = [1.08–1.39], I2 = 76%). Regarding the specific outcome, the incident risk for colorectal and lung cancers was significantly higher (OR = 1.06, 95% CI = [1.03–1.10], I2 = 10%, and OR = 1.36, 95% CI = [1.15–1.60], I2 = 90%, respectively) and that for breast cancer was lower (OR = 0.86, 95% CI = [0.77–0.97], I2 = 57%) in patients with CAD than in those without CAD. Conclusion CAD may be associated with incident cancer risk, particularly for lung and colorectal cancers, in men and women as well as patients with or without myocardial infarction. Early detection of new-onset cancer and detailed cancer surveillance programs should be implemented in patients with CAD to reduce cancer-related morbidity and mortality.

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Prevalence and risk of occult cancer in stroke

Cited by 8 publications

References 20 publications

Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

Types of occult cancer in stroke and the relation to smoking

Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

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