Prevalence, Antimicrobial Susceptibility Pattern, and Associated Factors of Urinary Tract Infections among Adult Diabetic Patients at Metu Karl Heinz Referral Hospital, Southwest Ethiopia

Gutema, Tesfaye; Weldegebreal, Fitsum; Marami, Dadi; Teklemariam, Zelalem

doi:10.1155/2018/7591259

Cited by 24 publications

(60 citation statements)

References 16 publications

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“…Bacteriological studies usually revealed the involvement of Gram-negative enteric organisms such as E. coli, Klebsiella species, Enterobacter species, and Proteus species in causing UTI. 17,31,32 Similarly, the predominant numbers of pathogens isolated in our study were Gramnegative bacilli (71.8%). Similarly, they were the dominant causative agent of UTIs in Harar, Gondar, rural South India, Iraq, Nepal, Sudan, and Kuwait.…”

Section: Discussionsupporting

confidence: 60%

“…Comparable findings have been reported in previous studies conducted in Addis Ababa (10.9%), 15 Debre Tabor (10.9%), 16 Hawassa (13.8%), 25 and Romania (12.0%). 9 However, this finding was relatively lower as compared to studies conducted in Harar (15.4%), 14 Addis Ababa (14.9%), 18 Gondar (17.8%), 26 Metu, Ethiopia (16.7%), 17 Nekemet, Ethiopia (16.5%), 27 and Sudan (19.5%). 13 It was much lower than reports from different parts of the world such as a study in Uganda (22.0%), 28 Kuwait (35%), 7 India (49.15%), 29 and Nepal (54.76%).…”

Section: Discussionmentioning

confidence: 85%

“…Globally, it ranges from 12% to 40.2% and in Ethiopia its prevalence is between 10.9% and 22.6%. [14][15][16][17][18] Several uropathogens have been identified in diabetic patients and the most common uropathogens isolated are Escherichia coli, Klebsiella spp., and Staphylococcus aureus. 7,9,12,18 Due to different reasons, these bacterial uropathogens showed wide-ranging resistances to different classes of antibiotics across the world.…”

Section: Introductionmentioning

confidence: 99%

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<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

Alemu¹,

Belete²,

Gebre-Selassie³

et al. 2020

DMSO

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Purpose: To determine the bacterial profile with its associated risk factors and to identify extended spectrum beta-lactamase producing Gram-negative bacterial uropathogens among diabetic patients at Dessie Referral Hospital, Northeastern Ethiopia. Materials and Methods: A hospital-based cross-sectional study was conducted from May to September 2018. A total of 336 diabetic patients were included using a simple random sampling technique. A structured questionnaire was used to collect socio-demographic and risk factor-related data. A 10-mL mid-stream urine specimen was collected and transported to the microbiology laboratory for culture, antimicrobial susceptibility testing, and detection of ESBL-producing bacteria. The data were entered into SPSS version 22, and descriptive statistics, bivariate and multivariate logistic regression analyses were performed. A p-value ≤0.05 with a 95% confidence interval was considered for statistical significance. Results: Among 336 diabetic patients, the overall prevalence of UTI was 11.6%. The predominant bacterial isolate was Escherichia coli 12/39 (30.8%), followed by Klebsiella pneumoniae 11/ 39 (28.2%) and coagulase-negative staphylococci 7/39 (17.9%). Gram-negative isolates showed 100% resistance to ampicillin, whereas Gram-positive isolates showed a high level of resistance to penicillin and tetracycline. Moreover, MDR was observed among 18 (46.2%) of the isolates and 2 of the isolated Gram-negative bacteria were ESBL producers. Being illiterate (AOR=7.226, 95% CI: (1.478, 35.340), p<0.015), having current symptoms of UTI (AOR = 2.702, 95% CI: (1.102, 6.624), p=0.030), and blood glucose level ≥126 mg/dl (AOR = 2.940, 95% CI: (1.080, 8.005), p=0.035) were significantly associated with the occurrence of bacterial UTI. Conclusion: The overall prevalence of significant bacteriuria (11.6%) in this study was comparable with some studies in Ethiopia and relatively lower than others. A moderately higher rate of resistance to the commonly used antimicrobial agents was noticed for both Gram-negative and Gram-positive isolates. Health information dissemination should be given about UTI, glycemic control, and habit of drug use for diabetes mellitus patients.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

Alemu¹,

Belete²,

Gebre-Selassie³

et al. 2020

DMSO

View full text Add to dashboard Cite

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“…Mama M et al has reported that E.Coli are highly sensitive to amoxicillin and chloremphenicol but Klebsiella was sensitive to trimethoprime and erythromycin. 21,22…”

Section: Discussionmentioning

confidence: 99%

A Clinical and Microbiological Profile of Urinary Tract Infection in Diabetes Mellitus Patients, a South India Perceptive

Sekhar¹,

Prasad²,

Rajyalakshmi³

2020

IJCMSR

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Introduction:Asymptomatic bladder infection that is detected by a positive urine culture is also common among diabetes mellitus patient which progress to symptomatic infection and subsequent complication. Therefore it becomes essential to screen urinary tract infection in diabetes mellitus patient so that its progress to complication can be prevented. Hence present study has been designated to know the clinical, microbiological profile and antimicrobial sensitivity pattern of organism that causes UTI in diabetes mellitus patient. Material and methods: Based on exclusion and inclusion criteria 100 patients were included in this study, A detailed history of the patient were taken with respect to duration of diabetes and its symptoms complication, type and treatment. Regarding urinary tract infection, history was taken with respect to dysuria, burning, suprapubic pain; urgency, increased frequency and haematuria fever with chill rigor and vomiting suggestive of acute pylonephritis. Result: Out of 100 patients 36 patients have bacteriuria and 64 patients were without bacteriuria. Patient with HbA1C% above 10, who were suffering from UTI were 43, out of them 21 having bacteria in urine. The P value was 0.0642 and chisquare statistic was 5.496, which is not significant. Regarding relation between FPG and UTI, those patient whose FPG was less than 110mg/dl., five of them have UTI and four have bacteria in urine and one were without bacteriuria. Conclusion: bacteriuria was more common in female then male and patient above 50 year of age are more affected then younger one. Patient with type 2 diabetes mellitus and treated with oral hypoglycaemic agent are effected more frequently. Bacteriuria was more common in patient whose glycocylated haemoglobin was more than 10% and fasting plasma glucose was more than 200mg/dl. Patients having neuropathy are more prone to UTI. Most common organism isolate were E.Coli and were sensitive to cephalosporins and aminoglycosides.

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“…The successful therapy for urinary tract infection depends on the identification of microbial agents and the selection of antimicrobial against them (Gutema et al 2018).The mainbacteria associated with urinary tract infection in diabetes are Escherichia coli, Enterococcus spp., Klebsiella spp., Proteus spp., Pseudomonas aeruginosa, Staphylococcus aureus, and coagulase-negative streptococcus. Other studies showed that fungi, namely, Candida spp.…”

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confidence: 99%

Antibiotic Sensitivity Pattern of Bacterial Isolates among Diabetic Outpatients with Urinary Tract Infection in Pontianak

2020

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Diabetic patients are associated with a higher risk of infection. The research purposed to identify antibiotic susceptibility patterns among diabetic outpatients with urinary tract infection in Pontianak. An experimental study was performed for 13 bacterial isolates of diabetic outpatients with urinary tract infection in the Clinic of Diabetes Mellitus, Sultan Syarif Mohamad Alkadrie Hospital, Pontianak. The disc diffusion method was used to perform the susceptibility of antibiotics to the bacterial isolates. Among 13 isolates, the most common causative agent of urinary tract infection was Escherichia coli (53.85%), followed by Pseudomonas aeruginosa (30.77%). Klebsiella spp and Enterobacter aerogenes were 7.69%. Most isolates of bacteria of the study had a high sensitivity to Cefepime (92.31%), then followed by Levofloxacin, Amikacin, and Meropenem for 84.62%. The study revealed low sensitivity of bacteria to Amoxicillin/Clavulanate, Co-Trimoxazole, Cefazoline and Ceftriaxone (30.77%, 23.08 %, 23.08%, 23.08%, respectively). All bacterial isolates had high resistance to Ampicillin. Moreover, multidrug resistance observed among bacterial isolates. Keywords: antibiotic susceptibility, diabetes, urinary tract infections

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Prevalence, Antimicrobial Susceptibility Pattern, and Associated Factors of Urinary Tract Infections among Adult Diabetic Patients at Metu Karl Heinz Referral Hospital, Southwest Ethiopia

Cited by 24 publications

References 16 publications

<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

A Clinical and Microbiological Profile of Urinary Tract Infection in Diabetes Mellitus Patients, a South India Perceptive

Antibiotic Sensitivity Pattern of Bacterial Isolates among Diabetic Outpatients with Urinary Tract Infection in Pontianak

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