Prévalence des effets indésirables de l’hydroxychloroquine (Plaquenil ® ) dans une population dermatologique : étude rétrospective sur 102 patients

Tétu, P.; Hamelin, A.; Lebrun‐Vignes, Bénédicte; Soria, Angèle; Barbaud, A.; Françès, Camille; Chasset, François

doi:10.1016/j.annder.2018.03.168

Cited by 15 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hydroxychloroquine should be avoided in patients with glucose-6-phosphate dehydrogenase deficiency to prevent hemolytic anemia. Both hydroxychloroquine and chloroquine have narrow therapeutic indices for chloroquine and are associated with gastrointestinal symptoms, retinopathy, deafness/ tinnitus, and life-threatening toxicity (cardiomyopathy, arrhythmias, and methemoglobinemia) [88]. Recently published data, pointed to increase frequency of ventricular arrhythmias associated with chloroquine therapy for COVID -19infection [89].…”

Section: Discussionmentioning

confidence: 99%

Potential Antiviral Effect of Chloroquine Therapy against SARS-CoV-2 Infection

Musa

2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has affected many countries with increasing morbidity and mortality. In the absence of an effective vaccine and medication, chloroquine may be a potential choice. AIM: This study aims to explore the role of the possible antiviral effects of chloroquine against SARS-CoV-2. MATERIALS AND METHODS: A systematic search of studies relating to the antiviral effects against coronaviruses was conducted between January 1, 1990, and up to May 26, 2020, for relevant studies using PubMed, Scopus, and Google Scholar. RESULTS: A total of 174 articles were initially identified. Ninety-seven papers were removed for failing to address the aim of the study. Seventy-seven full-text articles were retrieved for eligibility analysis. Ten studies focused on general inhibition of viral replication, ten evaluated its effects on angiotensin-converting enzyme 2, 19 addressed the effects on alkalizing the cellular pH, 25 concentrated on the immunomodulatory effect, two assessed the potential effects on sialic acid, and 24 explored the therapeutic outcome. CONCLUSION: Chloroquine has promising antiviral effects on SARS-CoV-2 at different levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential Antiviral Effect of Chloroquine Therapy against SARS-CoV-2 Infection

Musa

2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…who independently reviewed all tests. The three patients from Tenon Hospital have been previously reported (but without details of their eye involvement) [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…Higher HCQ levels have been statistically associated with cutaneous hyperpigmentation lesions, but the association is not considered clinically meaningful as levels overlapped substantially between cases and controls [ 19 ]. Higher HCQ levels have also been associated with retinopathy in a small study [ 20 ] and in a recent large clinical retrospective study of 537 SLE patients [ 21 ]. To analyse the risk factors for retinal toxicity, we conducted a case–control study comparing 23 SLE patients with HCQ retinopathy and 547 SLE patients treated with HCQ but without retinopathy.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for hydroxychloroquine retinopathy in systemic lupus erythematosus: a case–control study with hydroxychloroquine blood-level analysis

et al. 2020

View full text Add to dashboard Cite

Objective HCQ is an essential medication in SLE, proven to lengthen survival and reduce flares. Its use, however, is limited by its rare but severe ophthalmological complications. Here, we aimed to analyse factors associated with HCQ retinopathy including HCQ blood levels. Methods This case–control study compared SLE patients with and without HCQ retinopathy, defined by abnormal results for at least two of the following ophthalmological tests: automated visual fields, spectral-domain optical coherence tomography (SD-OCT), multifocal electroretinogram (mfERG) and fundus autofluorescence. We compared clinical and laboratory findings to assess risk factors for HCQ retinopathy. Results The study included 23 patients with confirmed retinopathy (cases) and 547 controls. In the univariate analysis, age (P < 0.001), height (P = 0.045), creatinine clearance (P < 0.001), haemoglobin concentration (P = 0.01), duration of HCQ intake, (P < 0.001), higher cumulative HCQ dose (P < 0.001) and geographical origin (West Indies and sub-Saharan Africa) (P = 0.007) were associated with the risk of retinopathy, while HCQ blood levels were not. In the multivariate analysis, only cumulative dose (P = 0.016), duration of intake (P = 0.039), creatinine clearance (P = 0.002) and geographical origin (P < 0.0001, odds ratio 8.7) remained significantly associated with retinopathy. Conclusion SLE patients on HCQ should be closely monitored for retinopathy, especially those from the West Indies or sub-Saharan Africa, or with renal insufficiency, longer HCQ intake or a high cumulative dose. Although reducing the daily dose of HCQ in patients with persistently high HCQ blood levels seems logical, these concentrations were not associated with retinopathy in this study with controls adherent to treatment.

show abstract

“…De même, chez une patiente présentant des réactions à l’eau tonique et à la quinine, l’épreuve de provocation orale à la chloroquine et à l’hydroquinidine était négative [38] . La fréquence de réactions allergiques liée aux quinoléines comme l’hydroxychloroquine ou la chloroquine semble difficile à estimer mais demeurerait faible, comme l’ont souligné deux études cliniques rétrospectives [49] , [50] .…”

Section: Discussionunclassified

Eau tonique et quinine – un cocktail de bicentenaire servi en pleine effervescence

Lefrère

Barbaud

Bagot

et al. 2021

Revue Française d'Allergologie

Self Cite

View full text Add to dashboard Cite

Objectifs de l’étude La pandémie à SARS-CoV-2 voit nombre de médias relayer la présence de quinine dans les eaux toniques. Si son effet antiviral a été soulevé in vitro , l’amalgame avec ses dérivés, comme l’hydroxychloroquine, suscite un attrait pour ces eaux. Dans le cadre supplémentaire du bicentenaire de la découverte de la quinine, l’objectif principal vise à analyser les réactions d’hypersensibilité liées à la consommation de boissons contenant de la quinine décrites dans la littérature. Patients et méthodes Nous avons analysé les cas publiés indexés sur Pubmed , Scopus , Google Scholar. Un score d’imputabilité de la quinine a été calculé pour chacune des observations. Un dosage de quinine a été pratiqué sur plusieurs breuvages dont la vérification de teneur n’avait pas fait l’objet de publication. Résultats En parallèle d’études pharmacocinétiques connexes, ce corpus compte 26 observations. Elles concernent principalement des hommes jeunes, dont la gravité des symptômes est variable : essentiellement dermatologique, avec érythème pigmenté fixe, exanthème généralisé, urticaires ; hématologique, avec thrombopénie, syndrome hémorragique, microangiopathie thrombotique ; plus rarement oculaire, cardiaque ou auditive. Le niveau d’imputabilité de la quinine est certain pour trois cas, probable pour vingt-deux, possible pour deux. Les teneurs testées des apéritifs et d’un vin cuit, toutes conformes aux normes, sont moindres que celle des eaux toniques. Discussion Peut-être sous diagnostiqué, le mécanisme majoritaire est de type immuno-allergique, sans qu’une réaction croisée avec d’autres quinoléines ait pu être montrée. Chez ces patients et les femmes allaitantes de nouveau-nés déficitaires en G6PD, tout médicament, phytothérapie, homéopathie, voire cosmétique contenant de la quinine, sur la base d’une liste didactique proposée, seraient à écarter.

show abstract

Prévalence des effets indésirables de l’hydroxychloroquine (Plaquenil ® ) dans une population dermatologique : étude rétrospective sur 102 patients

Cited by 15 publications

References 29 publications

Potential Antiviral Effect of Chloroquine Therapy against SARS-CoV-2 Infection

Potential Antiviral Effect of Chloroquine Therapy against SARS-CoV-2 Infection

Risk factors for hydroxychloroquine retinopathy in systemic lupus erythematosus: a case–control study with hydroxychloroquine blood-level analysis

Eau tonique et quinine – un cocktail de bicentenaire servi en pleine effervescence

Contact Info

Product

Resources

About