Prevalence estimates for chronic urticaria in the United States: A sex- and age-adjusted population analysis

Wertenteil, Sara; Strunk, Andrew; Garg, Amit

doi:10.1016/j.jaad.2019.02.064

Cited by 61 publications

(52 citation statements)

References 28 publications

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“…Only one case (3.85%) of NPU was found, in a patient with aquagenic urticaria. This data seem to confirm that NPUs are more common in young people [ 20 ]. However, we did not find significant differences between the two groups of patients by comparing the data related to the individual CIndU, probably due to the small number of elderly patients.…”

Section: Discussionsupporting

confidence: 77%

Prevalence of Chronic Inducible Urticaria in Elderly Patients

Napolitano

Fabbrocini

Stingeni

et al. 2021

JCM

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Background: No data currently exist regarding the epidemiology of chronic inducible urticarias (CIndUs) in the ≥65-year-old population. Objective: The study aimed to determine the prevalence of CIndUs among elderly patients affected by chronic urticaria (CU). Methods: The medical records of all patients referred to us with a diagnosis of CU from January 2008 to September 2020 were retrospectively reviewed, and the patients with CIndUs were identified. The subjects aged 65 years or above were included in the study. Results: The number of patients aged 65 years or above was 153 out of 1970 subjects affected by CU (7.77%; 92 females (60.13%); mean age 70.96 ± 4.22). Out of 153, 26 patients (16.99%; 20 females (76.9%); mean age 71.23 ± 2.6 years) were diagnosed with CIndUs. Most subjects (25/26; 96.15%) suffered from physical urticarias. Symptomatic dermographism was the most frequent, affecting 65.38% (17/26) of our patients, followed by cold urticaria (6/26 (23.08%) cases). Conclusion: Our data seem to indicate that CIndUs may also affect the elderly, although it occurs less frequently in aging patients than in lower age groups.

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Section: Discussionsupporting

confidence: 77%

Prevalence of Chronic Inducible Urticaria in Elderly Patients

Napolitano

Fabbrocini

Stingeni

et al. 2021

JCM

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“…Similar to previous studies, we found that CSU is a disease that disproportionately affects women and has a median age of onset in the fifth decade of life. Previous studies have suggested that the prevalence of CSU is similar among different ethnicities [2]. We found approximately half of our study population was Caucasian and about one-third were of Asian descent.…”

Section: Discussionsupporting

confidence: 44%

“…CSU affects individuals across their entire adult lifespan, with a slightly higher prevalence in patients in their fifth and sixth decades of life [ 2 ]. The prevalence of disease among various ethnicities is also felt to be fairly comparable [ 2 ]. Few studies have evaluated the natural history of CSU with conflicting results about long term remission rates [ 3 – 5 ] Most of these studies that have analyzed the natural history have been designed as single centered studies with limited long term follow up of patients.…”

Section: Introductionmentioning

confidence: 99%

“…A recent cross sectional analysis has estimated that CSU affects about 0.23% of the population in the United States, with women more than twice as likely to have the condition relative to men [2]. CSU affects individuals across their entire adult lifespan, with a slightly higher prevalence in patients in their fifth and sixth decades of life [2]. The prevalence of disease among various ethnicities is also felt to be fairly comparable [2].…”

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confidence: 99%

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Natural history, prognostic factors and patient perceived response to treatment in chronic spontaneous urticaria

Stepaniuk

Kan

Kanani

2020

Allergy Asthma Clin Immunol

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Background: Although the diagnosis and management of chronic spontaneous urticaria (CSU) is well documented in the literature, some aspects of the disease remain unclear. We aimed to further describe the natural history, prognostic factors, humanistic burden and uptake of traditional and alternative therapies in patients with CSU. Methods: This was a prospective, cross-sectional analysis at a single centre. We reviewed patient medical records and conducted a survey in patients with CSU. Results: 72 patients participated in the study with a median duration of CSU of 48 months. 30% of patients had symptoms that resolved in under 2 years with these patients trending towards an older age of onset of CSU (48 ± 17 years). 16% of patients had symptoms lasting 10 years or longer with these patients trending towards a younger age of onset (22 ± 16 years). Patients with a relapsing/remitting disease course (31%) and those with co-existing angioedema (57%) trended towards a longer median duration of CSU (96 and 50 months respectively) and were observed to have a higher proportion of patients reporting CSU duration of 10 years or longer (33% and 25%, p = 0.033 and p = 0.036 respectively). Patients with co-existing autoimmune/thyroid disease (19%) trended towards a shorter median duration of CSU (37 months). 54 patients (75%) reported sleep disturbance and 29 patients (43%) required emergency room visit(s) for symptomatic control. 84% of patients who trialed second generation antihistamines reported a response to treatment, while 73% of patients who trialed omalizumab reported a response to treatment. Patients using alternative medicine such as acupuncture, traditional Chinese medicine and naturopathic medicine had lower reported response rates (20-29%) to treatment. Conclusions: The natural history of CSU may be longer than previously reported with our study finding a median duration of symptoms of nearly 4 years with one-third of patients reporting a relapsing/remitting disease course. Younger age of onset, a relapsing/remitting disease course and angioedema may predict a longer duration of CSU, whereas older age of onset and co-existing autoimmune/thyroid disease may predict a shorter duration of CSU. Reported symptomatic benefit was higher from guidelines based pharmacologic therapy versus various alternative medicines.

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“…6 Regarding the characteristics of the studied population, the predominance of the female sex stands out both in the global sample and in all the participating centers, which is in line with previous studies. 3,6,12 As a limitation, this study only considers patients on a third line of treatment with cyclosporine or omalizumab and all the limitations regarding a retrospective study. It also only includes patients under follow-up because of specialties in dermatology or allergy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic urticaria refractory to antihistamines in Andalucia, Spain

Pereyra‐Rodriguez

Gutiérrez

Armario‐Hita

et al. 2020

Dermatologic Therapy

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Chronic urticaria (CU) has a devastating effect on the quality of life of patients who suffer from it. The objective of this study is to determine the prevalence of severe chronic spontaneous urticaria (CSU) in adults in eight health areas in Andalucía. A retrospective observational study from January 2019 to December 2019 was conducted with the participation of seven reference hospitals that were analyzed, including a total reference population of 3 159 001 individuals ≥18 years. The analysis was carried out on the characteristics of the population and the estimated prevalence. In total, 369 patients with a diagnosis of CSU refractory to antagonist of histamine were registered. We have found a prevalence of refractory patients of 0.0012% (95% CI 0.0010%-0.0013), ranging from 0.006% to 0.02%. The present study has helped to describe the prevalence and characteristics of patients with severe urticarial. The prevalence is lower than previously reported. We have observed differences between hospital areas. There will be a new line of research at the national level to help improve the identification of patients with CSU.

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Prevalence estimates for chronic urticaria in the United States: A sex- and age-adjusted population analysis

Cited by 61 publications

References 28 publications

Prevalence of Chronic Inducible Urticaria in Elderly Patients

Prevalence of Chronic Inducible Urticaria in Elderly Patients

Natural history, prognostic factors and patient perceived response to treatment in chronic spontaneous urticaria

Prevalence of chronic urticaria refractory to antihistamines in Andalucia, Spain

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