Prévalence et rôle des IgG anti-Chlamydia trachomatis chez une population d’hommes infertiles au Maroc

Frikh, Mohammed; Mrimar, Nadia El; Kasouati, Jalal; Hamzaoui, A.; Maleb, Adil; Lemnouer, Abdelhay; Choukairi, O.; Barkiyou, Malika; Ouennass, M. El

doi:10.1016/j.purol.2019.08.261

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…Chlamydia trachomatis (CT) is the most common sexually transmitted pathogen in high-income countries (101,102) and is the most common etiology of STIs among sexually active males 14 to 35 years of age (88). Ito et al (103) examined different microorganisms in men younger than 40 years of age with acute epididymitis and found that CT is a major pathogen (28%) while the prevalence of genital mycoplasmas (5%) and ureaplasmas were lower (5%).…”

Section: Immune Response Induced By Chlamydia Trachomatismentioning

confidence: 99%

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens

Zhao

et al. 2020

Front. Immunol.

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The epididymis is an important male accessory sex organ where sperm motility and fertilization ability develop. When spermatozoa carrying foreign antigens enter the epididymis, the epididymis shows "immune privilege" to tolerate them. It is well-known that a tolerogenic environment exists in the caput epididymis, while pro-inflammatory circumstances prefer the cauda epididymis. This meticulously regulated immune environment not only protects spermatozoa from autoimmunity but also defends spermatozoa against pathogenic damage. Epididymitis is one of the common causes of male infertility. Up to 40% of patients suffer from permanent oligospermia or azoospermia. This is related to the immune characteristics of the epididymis itself. Moreover, epididymitis induced by different pathogenic microbial infections has different characteristics. This article elaborates on the distribution and immune response characteristics of epididymis immune cells, the role of epididymis epithelial cells (EECs), and the epididymis defense against different pathogenic infections (such as uropathogenic Escherichia coli, Chlamydia trachomatis, and viruses to provide therapeutic approaches for epididymitis and its subsequent fertility problems.

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Section: Immune Response Induced By Chlamydia Trachomatismentioning

confidence: 99%

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens

Zhao

et al. 2020

Front. Immunol.

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“…In our series, the sperm culture performed in all patients found germs in only 29.58% of cases. Indeed, the ineffectiveness or lack of treatment of infections of the urogenital sphere allows a slow spread of inflammatory processes to the epididymis and testicles [4]. The main danger of especially chronic urogenital infections is dominated mainly by Chlamydia infection.…”

Section: Discussionmentioning

confidence: 99%

“…12 months is shortened to 6 months in the presence of an advanced age of the partner or a history of cryptorchidism [2] [3]. Infertility affects 80 million people worldwide, with one in ten couples experiencing infertility of either a primary or secondary nature [4]. Male infertility, isolated or not, is present in more than 50% of couple infertilities [5].…”

Section: Introductionmentioning

confidence: 99%

Profile of the Infertile Man at the University Hospital of Conakry (Guinea)

Bissiriou,

Daouda,

Oury

et al. 2023

OJU

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Introduction: Male infertility is defined as the inability of a man to impregnate a woman after 12 months of regular sexual intercourse without contraception. Objective: To improve the state of knowledge on the profile of the infertile man in Guinea. Methodology: We conducted a prospective, descriptive study over a period of 6 months from October 1st, 2020 to March 31st, 2021. Results: We collected an overall number of 71 patients seen onroutine consultation for infertility. They had a mean age of 36.4 years. More than half of our patients were monogamous (79% of cases). Civil servants were the most affected with 38.02% of cases. Primary infertility was dominant in 65% (n = 46) of cases. On clinical examination, varicocele was the most remarkable abnormality with 88.73% (n = 63) followed by testicular hypotrophy with 59.15% (n = 42). Azoospermia was the most frequent sperm abnormality with 22.54% (n = 16) followed by oligospermia with 15.49% (n = 11). Hormonal assessment based on FSH and LH was performed in 16 patients with azoospermia (22.53%). FSH elevation was associated with azoospermia in 6 patients, i.e. 8.45%, azoospermia associated with a normal FSH level accounting for 14.08% in our series. Conclusion: In our practice, male infertility is becoming more and more of a concern due to the increasing number of patients seeking treatment. The scarcity of a medical assistance for procreation unit alongside with more efficient diagnostic means constitutes a handicap for its management.

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“…Dans notre série, aucun facteur n´a été associé de façon significative à l´OATS ce qui suggère le dernier mécanisme cité à savoir l´infection asymptomatique. En effet, dans une autre étude de l´équipe [ 68 ], la prévalence de l´infection à Chlamydia trachomatis était de 58,5% chez les patients avec spermogramme anormal.…”

Section: Discussionunclassified

Prévalence de l´infertilité masculine dans un hôpital universitaire au Maroc

Frikh¹,

Benaissa²,

Kasouati³

et al. 2021

Pan Afr Med J

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Introduction l´infertilité du couple est devenue ces dernières années un problème de santé publique, dont l´origine peut être féminine, masculine ou mixte. L´origine masculine est incriminée dans 40% des cas. Au Maroc, la plupart des publications ont été axées sur les étiologies et les facteurs de risque de l´infertilité masculine. L´objectif de notre étude est l´évaluation de la prévalence de l´infertilité masculine et le profil des paramètres spermatiques chez les hommes infertiles ou à risque d´infertilité au sein d´un hôpital tertiaire à Rabat. Méthodes analyse de 482 patients adressés pour bilan d´infertilité du couple ou dans le cadre du bilan préopératoire d´une varicocèle ou d´une ectopie testiculaire. Les données démographiques, les facteurs de risque d´infertilité, le caractère primaire ou secondaire de l´infertilité ont été enregistrées pour chaque patient. Les paramètres spermatiques ont été étudiés et interprétés selon les normes actualisées de l´OMS en 2010 avec études des facteurs associés à leur perturbation. Résultats l´âge moyen des patients était de 35,35±8,81 ans. L´infertilité était primaire dans 61,8%. Les facteurs de risque d´infertilité les plus fréquemment retrouvés sont le tabac suivi par la varicocèle et l´infection. Le spermogramme était perturbé dans 53,1%. L´anomalie la plus fréquente était la perturbation de la vitalité (36,9%) suivie par la concentration spermatique (29,7%) et la morphologie (29,3%). L´âge était le seul facteur ayant un impact significatif sur le spermogramme (p=0,002). Les anomalies de la mobilité se voient à partir de 31 ans, la vitalité est perturbée à 34 ans, la morphologie à 35 ans et la concentration à 37 ans. L´azoospermie a été retrouvée dans 16,4% essentiellement associée à l´infertilité primaire. L´oligo-asthéno-tératospermie était l´association la plus représentée (26,2%). Conclusion l´infertilité masculine est fréquente dans notre contexte, l´âge étant son principal facteur de risque. La mobilité est le paramètre le plus précocement atteint.

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Prévalence et rôle des IgG anti-Chlamydia trachomatis chez une population d’hommes infertiles au Maroc

Cited by 7 publications

References 32 publications

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens

The Immune Characteristics of the Epididymis and the Immune Pathway of the Epididymitis Caused by Different Pathogens

Profile of the Infertile Man at the University Hospital of Conakry (Guinea)

Prévalence de l´infertilité masculine dans un hôpital universitaire au Maroc

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