Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Singh, Achintya D.; Singh, Prashant; Farooqui, Naba; Strand, Tor A.; Ahuja, Vineet; Makharia, Govind

doi:10.1111/jgh.15167

Cited by 14 publications

(14 citation statements)

References 57 publications

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“…We systematically reviewed and meta-analyzed 17 studies and 3759 patients (1582 with all-cause short stature and 2177 with idiopathic short stature), and found that the pooled seroprevalence of CeD based on positive anti-tTG Ab and AEA is 11.2% (95%CI: 4.0-21.2) and 9.7% (95%CI: 2.7-20.2) for all-cause and idiopathic short stature, respectively. Similarly, pooled prevalence of biopsy-confirmed CeD is 7.4% (95%CI: 4.7-10.6) and 11.6% (95%CI: 4.1-22.2), for all-cause and idiopathic short stature, respectively[ 31 ]. In summary, approximately 1 in 14 patients with all-cause short stature and 1 in 9 patients with idiopathic short stature has biopsy-confirmed CeD.…”

Section: Definite Indications For Screening For Cedmentioning

confidence: 99%

Who to screen and how to screen for celiac disease

Singh¹,

Singh²,

Ahuja³

et al. 2022

WJG

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Celiac disease (CeD) is a chronic gluten-induced enteropathy with plethoric manifestations. The typical manifestations of CeD such as chronic diarrhea and malabsorption are widely recognized, however, many patients have atypical manifestations like iron deficiency anemia, idiopathic short stature, hypertransaminesemia or infertility, etc. These patients often present to the primary care physicians and/or non-gastrointestinal specialties. However, due to a lack of awareness among the healthcare professionals about the various atypical manifestations, many patients are not screened for CeD. In this review, we have summarized the available literature about the prevalence of CeD in various gastrointestinal (chronic diarrhea) and non-gastrointestinal conditions (iron deficiency anemia, short stature, cryptogenic hypertransaminesemia, cryptogenic cirrhosis or idiopathic ataxia etc. ) where the diagnosis of CeD should be con-sidered. In addition, we also discuss special scenarios where screening for CeD should be considered even in absence of symptoms such as patients with type 1 diabetes, Down’s syndrome, and first-degree relatives of patients with CeD. Further, we discuss the diagnostic performance and limitations of various screening tests for CeD such as IgA anti-tissue transglutaminase antibodies, anti-endomysial antibodies and anti-deamidated gliadin antibodies. Based on the current recommendations, we propose a diagnostic algorithm for patients with suspected CeD.

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Section: Definite Indications For Screening For Cedmentioning

confidence: 99%

Who to screen and how to screen for celiac disease

Singh¹,

Singh²,

Ahuja³

et al. 2022

WJG

Self Cite

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“…These data were confirmed by a recent systematic review including 3759 patients, in which prevalence of CD confirmed by a biopsy ranged from 7.4% to 11.6% for all-cause and idiopathic short stature [ 94 ]. Therefore, it is important to screen patients with short stature, both children and adults, for CD.…”

Section: Endocrinological-associated Diseasesmentioning

confidence: 54%

Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?

Durazzo

Ferro

Brascugli

et al. 2022

JCM

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Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis.

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“…Recently a meta-analysis was published in 2020 on the prevalence of celiac disease in patients with short stature. They included 17 studies in their analysis [19]. Their results showed that three studies reported sero-prevalance of CD among short stature children and it was 11.2 (95% CI=4.5 -21.2) [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Short Stature and Celiac Disease in Children (5 to 16 Years) Presenting at a Tertiary Care Hospital in Peshawar

Amir¹,

Arif²,

Wajid³

et al. 2022

Cureus

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Background: Malabsorption is the typical presentation of celiac disease in early childhood, whereas older children can present with extra-intestinal symptoms including short stature and delay in pubertal development.Objective: To determine the frequency of celiac disease in shortening of stature in children.Material and methods: This descriptive, cross-sectional study was conducted at the Pediatric Department in Lady Reading Hospital, Peshawar, on 152 short stature children of both genders aged 5 to 16 years. Children with dysmorphic faces, syndromes, endocrine disorders, and children or their parents who refused to give consent were excluded. Anthropometric measurement was done on standard equipment. Height and weight were plotted on WHO centile charts. All the children fulfilling inclusion criteria were advised serologic antitissue transglutaminase antibodies tests.Results: Overall the frequency of celiac disease was 33.77% (n=51) among the children with short stature. The mean age of the study was 6.71±1.52 years. There were 76 males (50.3%), while there were 75 females 49.7%. The frequency of celiac disease among short stature females was higher (n=28, 54.9%) than short stature males (n=23, 45.1%). However, the results were not statistically significant (P=0.358). The frequency of celiac disease stratified by age group was not statistically significant (P=0.491).Conclusion: One-third of children having short stature have celiac disease. The frequency of celiac disease in children with short stature has no association with gender and age.

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Prevalence of celiac disease in patients with short stature: A systematic review and meta‐analysis

Cited by 14 publications

References 57 publications

Who to screen and how to screen for celiac disease

Who to screen and how to screen for celiac disease

Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?

Short Stature and Celiac Disease in Children (5 to 16 Years) Presenting at a Tertiary Care Hospital in Peshawar

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