Prevalence of eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease symptoms: A prospective study

García-Compeán, Diego; Gonzalez, Jose A.; García, César Antonio Marrufo; Gutiérrez, Juan Pablo Flores; Quintana, Oralia Barboza; Rodríguez, Guadalupe; Ruiz, Miguel Angel Mar; Valdez, David de León; Quintana, Joel Omar Jáquez; Garza, Héctor J. Maldonado

doi:10.1016/j.dld.2010.08.002

Cited by 90 publications

(63 citation statements)

References 31 publications

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“…4,8,9,10 En México, la esofagitis eosinofílica (EEo) afecta entre 1.7 y 4 % de la población adulta con enfermedad por refl ujo gastroesofágico (ERGE) resistente al tratamiento convencional, sin embargo, no encontramos estudios similares en niños. 11 La fi siopatología de estas entidades aún es poco clara; hasta el momento, la EEo es la más conocida. Los basófi los y las células presentadoras de antígeno son activadas por la linfopoyetina tímica estromal…”

Section: Antecedentesunclassified

Caracterización epidemiológica, clínica y diagnóstica de niños con gastroenteropatía eosinofílica. Estudio retrospectivo de tres instituciones de salud de alta complejidad

Holguín

Gallego-Yepes

Toro

et al. 2018

RAM

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Antecedentes: Los desórdenes gastrointestinales eosinofílicos son poco frecuentes. En Colombia no hay estudios en población pediátrica.Objetivo: Describir características epidemiológicas, clínicas y diagnósticas de una población pediátrica con desórdenes gastrointestinales eosinofílicos.Métodos: Estudio observacional, retrospectivo en niños entre 0 y 12 años evaluados en tres hospitales de alta complejidad de Medellín, Colombia, entre 2010 y 2015.Resultados: De 151 niños, 74 (49 %) padecían esofagitis eosinofílica, 35 (23.2 %) gastritis eosinofílica, 20 (13.2 %) duodenitis eosinofílica y 65 (43 %) ileítis o colitis eosinofílica; 60.9 % era del sexo masculino, la mediana de edad fue de cinco años, 66.9 % tenía antecedente de enfermedad alérgica y 78.8 %, afectación de un solo segmento del tracto gastrointestinal. Los principales síntomas fueron dolor abdominal y vómito. El conteo máximo de eosinófilos por campo de alto poder en esófago, estómago, duodeno, íleon y colon fue de 34, 21, 42, 45 y 60, respectivamente. La eosinofilia periférica fue más frecuente en pacientes con afectación de esófago y estómago. Los alimentos más sensibilizantes fueron huevo, leche, camarón, trigo y pollo. Se utilizaron inhibidores de bomba de protones, esteroides o inmunosupresores y dietas de exclusión de alimentos.Conclusiones: Los desórdenes gastrointestinales eosinofílicos pueden afectar múltiples segmentos y sus síntomas son inespecíficos, por lo que se requiere manejo multidisciplinario.

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Section: Antecedentesunclassified

Caracterización epidemiológica, clínica y diagnóstica de niños con gastroenteropatía eosinofílica. Estudio retrospectivo de tres instituciones de salud de alta complejidad

Holguín

Gallego-Yepes

Toro

et al. 2018

RAM

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“…The few studies reporting endoscopic findings in this select patient group clearly indicate that the probability of detecting mucosal erosions is far less than 10 % [5]. Even histologic evaluation for eosinophilic esophagitis in these patients is disappointing, because its prevalence appears to be less than 5 % [6]. However, despite its poor sensitivity, upper GI endoscopy may be fundamental in reassuring both the patient and the doctor and may be reasonably indicated in three circumstances: (1) if it was not performed previously, (2) if mucosal biopsies are not available, and (3) if the patient previously had a diagnosis of severe esophagitis.…”

Section: Diagnostic Approachmentioning

confidence: 93%

PPI-Refractory GERD: an Intriguing, Probably Overestimated, Phenomenon

Baldi

2015

Curr Gastroenterol Rep

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“…To exclude eosinophilia, which might be associated with gastroesophageal disease (GERD), the patients whose esophageal biopsies were obtianed from the middle and the proximal regions were enrolled in the study. 4,13,14 Although eosinophilia due to gastroeosephageal reflux disease is usually present in the distal esophagus, eosinophilia of eosinophilic esophagitis can be seen in the any part of the esophagus. 4 Liacouras et al determined 100% sensitivity when they compared mid-esophageal biopsy with distal esophageal biopsy in the diagnosis of the EoE.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Eosinophilic Esophagitis in Patients with Dysphagia in the Turkish Population

Ugiş¹,

Doğan²,

Ekinci³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : In this study we aimed to investigate the prevalence of eosinophilic esophagitis (EoE) among patients with dysphagia in the Turkish population. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Patients with dysphagia were enrolled in the study. The enrolled patients underwent esophagogastroduodenoscopy and esophageal biopsies were obtained-one from proximal and one from mid-esophagus. Esophageal motor disorders (EMD) which can cause dysphagia (achalasia etc) were excluded by esophagial manometry. The diagnosis of EoE was made when patients had chronic esophageal symptoms and the esophageal biopsy showed >15 eosinophils/high-power field (HPF). R Re es su ul lt ts s: : A total of 107 patients with dysphagia were enrolled in the study. After exclusion of patients with EMD and other structural or systemic diseases, 55 patients were left in the study. Ten of 55 patients (18.2%) were male and the median age of patients was 45 (18-80) years. All patients had dysphagia. Overall 37 (67.3%) had regurgitation, 35 (63.6%) pyrosis, 9 (16.4%) epigastric pain, 17 (30.9%) nausea and one patient (1.8%) had vomiting. In the initial routine histopathological examination, five patients reported to have eosinophilic esophagitis but re-evaluation of histopathological findings revealed that only one patient met the diagnostic criteria for Eosinophilic Esophagitis (EoE). However, gastric biopsy of this patient showed intense eosinophilic infiltration and the diagnosis of eosinophilic gastroenteritis was more likely in that patient. C Co on nc cl lu us si io on n: : As a result, despite the small number of patients, eosinophilic esophagitis is suggested to be one of the least common causes of dysphagia among adult patients in the Turkish population.K Ke ey y W Wo or rd ds s: : Eosinophilic esophagitis; deglutition disorders Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışma, disfaji nedeniyle başvuran Türk hastalarda eozinofilik özofajit sıklığını araştırmak amacıyla planlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya disfajisi olan hastalar alındı. Çalışmaya alınan hastalara özofagogastroduodenoskopi yapıldı. Özofagus orta ve proksimalinden birer biyopsi alındı. Disfajiye neden olabilecek özofagus motor fonksiyon bozuklukları özofagiyal manometri ile dışlandı. Eozinofilik özofajit tanısı, disfajisi olan hastaların biyopsilerinde bir büyük büyütme alanında >15 eozinofil olması ile konuldu. B Bu ul lg gu ul la ar r: : Çalışmaya toplam 107 hasta alındı. Dışlama kriterlerine göre motor fonksiyon bozukluğu ve diğerleri çıkarıldıktan sonra 55 hasta kaldı. Elli beş hastanın 10 (%18,2)'u erkek olup, ortanca yaş 45 (18-80) idi. Bütün hastalarda disfaji vardı. Hastaların 37 (%67,3)'sinde regürjitasyon, 35 (%63,6)'inde pirozis, 9 (%16,4)'unda epigastrik ağrı, 17 (%30,9)'sinde bulantı ve 1 (%1,8)'inde kusma saptandı. İlk rutin histopatolojik incelemede 5 hastada eozinofilik özofajit olduğu raporlandı; fakat eozinofilik özofajit kriterlerine göre tekrar değer-lendiri...

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Prevalence of eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease symptoms: A prospective study

Cited by 90 publications

References 31 publications

Caracterización epidemiológica, clínica y diagnóstica de niños con gastroenteropatía eosinofílica. Estudio retrospectivo de tres instituciones de salud de alta complejidad

Caracterización epidemiológica, clínica y diagnóstica de niños con gastroenteropatía eosinofílica. Estudio retrospectivo de tres instituciones de salud de alta complejidad

PPI-Refractory GERD: an Intriguing, Probably Overestimated, Phenomenon

Prevalence of Eosinophilic Esophagitis in Patients with Dysphagia in the Turkish Population

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