Prevalence of erectile dysfunction in chronic renal disease patients on conservative treatment

Mesquita, J. F.; Ramos, Thiago Faria; Mesquita, Felipe Pereira; Netto, José Murillo Bastos; Bastos, Marcus Gomes; Figueiredo, André Avarese de

doi:10.6061/clinics/2012(02)15

Cited by 30 publications

(34 citation statements)

References 9 publications

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“…Endothelial dysfunction is an early marker of CVD, and it has also been reported to occur in CKD patients [26,27]. In addition, endothelial dysfunction is a cause of ED, because nitric oxide production from the endothelium decreases in this state.…”

Section: Discussionmentioning

confidence: 99%

Cardiorenal Determinants of Erectile Dysfunction in Primary Prevention: A Cross-Sectional Study

Dženkevičiūtė

Petrulionienė²,

Rinkūnienė

et al. 2017

Med Princ Pract

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Objective: The aim of this study was to investigate the association between the severity of erectile dysfunction (ED), cardiovascular risk, and target organ damage (heart, renal, vascular) in men free of cardiovascular diseases (CVD). Subjects and Methods: ED was assessed using the International Index of Erectile Function (IIEF-5). The studyincluded 182 men: 100 with ED (IIEF mean score ≤21) and 82 without ED (IIEF mean score >21). Ultrasound was used to evaluate carotid plaques and left ventricular mass, geometry, and diastolic function. Cardiovascular anamnesis, CVD risk factors, and anthropometric and biochemical parameters were obtained. The European Society of Cardiology-Systematic Coronary Risk Evaluation Score (ESC-SCORE) was used to calculate total patient cardiovascular risk. Continuous variables between groups were compared using the Student t test and Mann-Whitney U test, while categorical data were compared using the χ² test. Multiple linear regression was used to test the association between the severity of ED and presence of target organ damage. Results: The following parameterswere significantly higher in the ED group compared to the controls: family history of coronary heart disease (43.7 vs. 26.7%, p = 0.047), ESC-SCORE (2.27 ± 1.79 vs. 1.61 ± 1.13, p = 0.012), and waist circumference (109.28 ± 10.82 vs. 106.17 ± 10.07, p = 0.047). Impaired renal function (p = 0.081), albuminuria (p = 0.545), vascular damage (p = 0.602), and diastolic function (p = 0.724) were similar in both groups. However, left ventricular hypertrophy (LVH; odds ratio 2.231, 95% CI 1.069-4.655, p = 0.22) was more frequent in the ED group (29.9 vs. 16.0%).The multiple linear regression analysis revealed that LVH (β = 1.761, p = 0.002) and impaired renal function assessed using the estimated glomerular filtration rate (<60 mL/min/1.73 m²; β = 6.207, p = 0.0001) were the independent risk factors for severity of ED. Conclusion: This study showed that LVH and impaired renal function are associated with ED severity.

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Section: Discussionmentioning

confidence: 99%

Cardiorenal Determinants of Erectile Dysfunction in Primary Prevention: A Cross-Sectional Study

Dženkevičiūtė

Petrulionienė²,

Rinkūnienė

et al. 2017

Med Princ Pract

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“…On the other hand, in the Rancho-Bernando Study elevated serum cholesterol levels and triglyceride levels were associated with more severe ED, as men without ED had lower cholesterol levels compared to men with moderate ED (P < 0.05), and men with no sexual activity strong association between hypertension and the emerge of erectile dysfunction has been well established in several other studies [38,41,45] , data occasionally remain uncertain if hypertension is an independent risk factor for [28,42] . Although the frequency of hypertension is high among patients with CKD in rates reaching even 70%-95%, its association with sexual dysfunction among these patients is not always statistically significant [29,32,36,43] . Erectile dysfunction observed in hypertensive patients may be associated with the disease itself or it may be caused by the antihypertensive therapy being administered to these patients.…”

Section: Effect Of Comorbiditiesmentioning

confidence: 96%

“…Mesquita et al [32] reported that the prevalence of ED or severe/complete ED had higher triglyceride levels than men without ED (P < 0.05) [37] . In a prospective study among 2869 men, Ponholzer et al [38] reported that hyperlipidemia was independently and significantly correlated to the presence of erectile dysfunction with an OR of 2.29 (P = 0.04).…”

Section: Prevalencementioning

confidence: 98%

“…Nevertheless, in a study including 119 men with CRF in hemodialysis program, the highest prevalence of ED was among men whose kidney disease was due to diabetes [36] . Rosas et al [26] found that men with diabetes had twice the odds of suffering from erectile dysfunction compared to nondiabetic men in a cohort study among 302 subjects in hemodialysis, whereas Mesquita et al [32] reported that among 81 patients with CKD, diabetic patients were 4 times more likely to have impaired erectile function compared to non-diabetic subjects (P = 0.048).…”

Section: Prevalencementioning

confidence: 99%

“…Erectile and kidney dysfunction share common risk factors and are associated with diseases involving endothelial impairment such as diabetes mellitus, hypertension, dyslipidemia, coronary artery disease, smoking and obesity [32] . Cigarette smoking is an established modifiable risk factor of arteriosclerosis.…”

Section: Effect Of Comorbiditiesmentioning

confidence: 99%

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Erectile dysfunction in chronic kidney disease: From pathophysiology to management

Papadopoulou

Varouktsi

Lazaridis

et al. 2015

WJN

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Chronic kidney disease (CKD) is encountered in millions of people worldwide, with continuously rising incidence during the past decades, affecting their quality of life despite the increase of life expectancy in these patients. Disturbance of sexual function is common among men with CKD, as both conditions share common pathophysiological causes, such as vascular or hormonal abnormalities and are both affected by similar coexisting comorbid conditions such as cardiovascular disease, hypertension and diabetes mellitus. The estimated prevalence of erectile dysfunction reaches 70% in end stage renal disease patients. Nevertheless, sexual dysfunction remains under-recognized and under-treated in a high proportion of these patients, a fact which should raise awareness among clinicians. A multifactorial approach in management and treatment is undoubtedly required in order to improve patients' quality of life and cardiovascular outcomes.

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The Old Made New: Natural Compounds against Erectile Dysfunction

Pavan

Mucignat‐Caretta

Redaelli

et al. 2015

Archiv der Pharmazie

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The interest toward sex-related diseases keeps growing through the years. In this review, we focus our attention on erectile dysfunction (ED), a condition that caught much attention especially after the introduction on the market of phosphodiesterase 5 inhibitors such as the well-known sildenafil. Here, we briefly describe both the etiology of ED and the available treatments, examining then extensively some natural derivatives that, coming from traditional medicine, could represent promising starting points for the development of alternative remedies. In fact, herbal remedies from several parts of the world have been traditionally known for long, and were recently reconsidered and are now being studied to demonstrate their eventual potential in the treatment of ED. Among the various examples reported in the literature and reviewed here, plants and extracts containing polyphenols—especially a class of compounds called kraussianones—appear to be particularly effective and promising against ED.

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Prevalence of erectile dysfunction in chronic renal disease patients on conservative treatment

Cited by 30 publications

References 9 publications

Cardiorenal Determinants of Erectile Dysfunction in Primary Prevention: A Cross-Sectional Study

Cardiorenal Determinants of Erectile Dysfunction in Primary Prevention: A Cross-Sectional Study

Erectile dysfunction in chronic kidney disease: From pathophysiology to management

The Old Made New: Natural Compounds against Erectile Dysfunction

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