Prevalence of Factor V Leiden and other thrombophilic traits among Cretan children with malignancy

Stiakaki, Eftichia; Germanakis, Ioannis; Sfyridaki, Caterina; Katzilakis, Nikos; Danilatou, Vassiliki; Kalmanti, Maria

doi:10.1002/pbc.20125

Cited by 13 publications

(18 citation statements)

References 37 publications

(63 reference statements)

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“…46 Apart from the German study, six other studies evaluated thrombophilia in children with ALL and four of them studied the impact of thrombophilia on the development of TE (Table 2). 16,26,[67][68][69][70][71] These studies reported wide variability in the prevalence of thrombophilia (18 to 40%). This probably reflects the differences in the ethnicity of the population studied and in the extent of thrombophilia tested.…”

Section: Role Of Inherited Prothrombotic Defectsmentioning

confidence: 99%

Thromboembolic Complications in Pediatric Hematologic Malignancies

Athale

Chan

2007

Semin Thromb Hemost

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Thromboembolism (TE) is an uncommon entity in childhood. Overall 25% of children with thrombosis and more than 40% of children with central venous line (CVL) -related TE enrolled on the Canadian Pediatric Thrombophilia Registry had underlying diagnosis of cancer. However, so far there are very little data describing the epidemiology of TE in children with cancer. Most of the available information in this area originates mainly from retrospective and some prospective observational cohort studies conducted in children with acute lymphoblastic leukemia (ALL). Although ALL has been the most common cancer reported in association with thrombosis in children, available data from small studies indicate that TE is equally common in children with acute myeloid leukemia and lymphoma. TE in association with leukemia and lymphoma seems to be a multifactorial entity. Potential risk factors include increased thrombin generation related to leukemia, age of the patients, use of CVL, chemotherapy including asparaginase and corticosteroids, infections, and inherited prothrombotic state. Management of TE in a child with cancer presents a unique challenge in terms of balancing risk versus benefit. Conservative therapy could lead to clot extension and risks of additional morbidity or mortality; however, chemotherapy-related thrombocytopenia and coagulopathy increase the risk of bleeding complications. In summary, TE is a frequent and serious complication in children with hematologic malignancies. More prospective studies are required to define the epidemiology, pathogenesis, and management of TE in children with hematologic malignancies.

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Section: Role Of Inherited Prothrombotic Defectsmentioning

confidence: 99%

Thromboembolic Complications in Pediatric Hematologic Malignancies

Athale

Chan

2007

Semin Thromb Hemost

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“…However, current evidence regarding the role of PD in the development of ALL‐associated TE is contradictory . Probably related to the different ethnicity of the population studied and marked variability in the extent of thrombophilia tested, there is a wide variability in the reported prevalence of thrombophilia (18–40%) and frequency of ALL‐associated TE in children with thrombophilia . Further, use of different therapy protocols and small sample size makes it difficult to interpret the data …”

Section: Introductionmentioning

confidence: 99%

Impact of baseline clinical and laboratory features on the risk of thrombosis in children with acute lymphoblastic leukemia: A prospective evaluation

Athale

Mizrahi

Laverdière

et al. 2018

Pediatric Blood & Cancer

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“…Cumulative data suggest that Cretans exhibit certain genetic differences in comparison with other populations (Stiakaki et al, 2005;Apostralis et al, 2005;Fragouli et al, 2008) and distribution of HLA alleles is peculiar (Arnaiz-Villena et al, 1999). At this stage of analysis, we can't establish if the highest frequency of the 35delG mutation we observed in Crete could be the result of genetic drift owing to founder effect and/or to geographic isolation of the island.…”

Section: Resultsmentioning

confidence: 74%

Original Synthetic Report: Carrier frequencies of the common <i>GJB2</i> (connexin-26) 35delG mutation in the Greek-Turkish area: predominance of the mutation in Crete

Yanakakisa¹,

Dieterlen²,

Neocleous³

et al. 2010

Int.J.Mod.Anthrop

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-Mutation 35delG in the connexin-26 gene is the main cause of recessive deafness in Europe. The aim of this study is to determine the percentage of carriers of this mutation in seven regions of the Greek-Turkish area; previous studies indicated that the prevalence of the mutation was relatively elevated in Greece. This study has been carried out on the genomic DNAs of a total of 1038 healthy subjects originating from Albania, Bulgaria, Athens (Greece) and Crete, and within Turkish origin from Ankara, Istanbul and Cyprus. Genotyping were performed using an allele-specific PCR protocol.The most elevated value of carrier frequency (5.36%) obtained concerns the Cretan population. Carrier frequencies are = 3.66% in Athens, = 1.34% in Istanbul and = 0.40% in Ankara. No carrier of the mutation was found in individuals with Turkish origin from Cyprus, Albania and Bulgaria. These results were compared to those already obtained in other published populations in the same area. A 35delG-allelic map in this area was constructed, which confirms that Crete corresponds to the most elevated value obtained.We discuss the historico-geographical and genetic arguments explaining this 35delG focus of elevated frequency in Crete.

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Prevalence of Factor V Leiden and other thrombophilic traits among Cretan children with malignancy

Abstract: Thrombophilic traits were relatively common in this group of native Cretan children treated for malignancy. Thromboprophylaxis should be considered in Cretan children in the presence of known acquired risk factors for thrombosis, but a larger prospective to study is first needed.

Cited by 13 publications

References 37 publications

Thromboembolic Complications in Pediatric Hematologic Malignancies

Thromboembolic Complications in Pediatric Hematologic Malignancies

Impact of baseline clinical and laboratory features on the risk of thrombosis in children with acute lymphoblastic leukemia: A prospective evaluation

Original Synthetic Report: Carrier frequencies of the common <i>GJB2</i> (connexin-26) 35delG mutation in the Greek-Turkish area: predominance of the mutation in Crete

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