Prevalence of hepatitis E virus and its association with adverse pregnancy outcomes in pregnant women in China

Qian, Zhongyao; Li, Tengyuan; Zhang, Yike; Chen, Shuangfeng; Zhang, Hui; Mickael, Houfack Kenfack; Duan, Xin; Xia, Yueping; Cong, Chao; Xu, Liangheng; Wei, Du; Wu, Yu; Yu, Xiongwu; Huang, Fen

doi:10.1016/j.jcv.2022.105353

Cited by 15 publications

(25 citation statements)

References 41 publications

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“…The infection is typically spread through contaminated water, infected animals or through ingestion of undercooked food. Hepatitis E patients have a significantly higher mortality rate 7 and adverse maternal outcomes risk in pregnant women 8 . HEV infection also accelerates decompensation and increases mortality of patients suffering with liver cirrhosis 9 …”

Section: Introductionmentioning

confidence: 99%

“…Hepatitis E patients have a significantly higher mortality rate 7 and adverse maternal outcomes risk in pregnant women. 8 HEV infection also accelerates decompensation and increases mortality of patients suffering with liver cirrhosis. 9 HEV is a major cause of acute viral hepatitis globally, with high seroprevalence in many countries ranging from 0.25% to more than 70% in certain populations.…”

Section: Introductionmentioning

confidence: 99%

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Increasing positive rate of IgG against hepatitis E virus with steady IgM positivity and clinical incidence: A retrospective seroprevalence time series analysis of HEV from 2012 to 2021 in Chongqing, China

Shi

Wang

Cao

et al. 2023

Journal of Medical Virology

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China is an epidemic area of hepatitis E, and the serum prevalence data is very important for formulating prevention and control strategies. However, almost all related research in the past decade are cross‐sectional studies. In this study, we analyzed the serological data from 2012 to 2021 in Chongqing for 10 consecutive years. We found that the positive rate of hepatitis E IgG antibody increased gradually, from 1.61% in January 2012 to 50.63% in December 2021. The autoregressive integrated moving average model was used to predict the trend, and it was found that it will continue to show an upward trend in the recent future. In contrast, the positive rate of IgM and clinical incidence of hepatitis E showed a relatively stable trend. Although the positive rate of antibodies gradually increased with age, there was no significant difference in the age distribution of the subjects each year. Therefore, these results suggest that the accumulated infection of hepatitis E in Chongqing may be gradually increasing, but the clinical incidence rate remains unchanged, which provides a new concern for formulating prevention and control strategies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increasing positive rate of IgG against hepatitis E virus with steady IgM positivity and clinical incidence: A retrospective seroprevalence time series analysis of HEV from 2012 to 2021 in Chongqing, China

Shi

Wang

Cao

et al. 2023

Journal of Medical Virology

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Some studies have explored the impact of sporadic HEV infection on the health of pregnant women and their fetuses or neonates in developed countries and contemporary China, where HEV-3 and HEV-4 infections play a dominating role and lead to sporadic cases [ 4 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. However, these studies have provided conflicting conclusions [ 4 , 17 , 18 , 19 , 20 , 21 , 22 ]. For instance, Bouthry et al [ 20 ] reported that HEV-infected pregnant women in France exhibited nonspecific symptoms or asymptomatic alanine aminotransferase elevation, and no adverse outcomes were noted in these women or their neonates.…”

Section: Introductionmentioning

confidence: 99%

“…Similar findings were observed in previous studies conducted in China [ 22 ] and Germany [ 17 ]. Nevertheless, recent studies have demonstrated that HEV infections can lead to various adverse outcomes in pregnant women and their fetuses or neonates in China and the United States [ 4 , 18 , 19 , 21 ]. Wasuwanich et al [ 18 ] documented that although no maternal or fetus/neonate deaths were reported in the United States, considerable adverse events were observed in HEV-infected pregnant women and their fetuses/neonates.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Hepatitis E Virus and Its Associated Outcomes among Pregnant Women in China

Wen,

Wang,

Tang

et al. 2023

Pathogens

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Hepatitis E virus (HEV) is a significant public health concern worldwide. Pregnant women are at high risk of severe HEV infection. Various adverse outcomes in pregnant women related to HEV infection have been well documented in low-income and middle-income countries with poor sanitation. However, previous studies have provided inconsistent conclusions regarding the effects of HEV infection on the health of pregnant women and their infants in developed countries and contemporary China. In China, previous studies on HEV in pregnant women mainly focused on anti-HEV IgM and/or anti-HEV IgG. In this study, 4244 pregnant women were retrospectively analyzed for HEV-related markers. The positive rates of HEV antigen, HEV RNA, anti-HEV IgM, and anti-HEV IgG were 0.28%, 0.54%, 0.35%, and 10.49%, respectively. Among the 467 pregnant women who tested positive for at least one HEV-related marker, 92.93% (434) were positive for anti-HEV IgG only and 0.21% (1) were positive for HEV antigen, anti-HEV IgM, and anti-HEV IgG. Although the prevalence of anti-HEV IgG significantly increased with age, the prevalence of anti-HEV IgM, HEV RNA, and HEV antigen did not differ among pregnant women of different ages. Thirty-three pregnant women were positive for at least one of anti-HEV IgM, HEV antigen, and HEV RNA, and these individuals were recently or currently infected with HEV. None of the 33 pregnant women exhibited obvious clinical symptoms. Of the 33 pregnant women, 39.39% (13) experienced adverse fetal outcomes, including preterm birth, fetal distress, and low birth weight, the incidence of which was significantly higher than in pregnant women who were not recently or currently infected with HEV. These findings suggest that maternal HEV infection may impact the health of fetuses; thus, these results may contribute to the development of appropriate public health interventions for this population.

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Development and validation of a nomogram for predicting intellectual disability in children with cerebral palsy

Yuan,

Wang,

et al. 2024

International Journal of Clinical and Health Psychology

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Prevalence of hepatitis E virus and its association with adverse pregnancy outcomes in pregnant women in China

Cited by 15 publications

References 41 publications

Increasing positive rate of IgG against hepatitis E virus with steady IgM positivity and clinical incidence: A retrospective seroprevalence time series analysis of HEV from 2012 to 2021 in Chongqing, China

Increasing positive rate of IgG against hepatitis E virus with steady IgM positivity and clinical incidence: A retrospective seroprevalence time series analysis of HEV from 2012 to 2021 in Chongqing, China

Prevalence of Hepatitis E Virus and Its Associated Outcomes among Pregnant Women in China

Development and validation of a nomogram for predicting intellectual disability in children with cerebral palsy

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