Prevalence of hidradenitis suppurativa among patients with Down syndrome: a population-based cross-sectional analysis

Abstract

HS is strongly associated with DS across demographic subgroups and may present earlier in life for these patients.

Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis

“…In addition, the association was reported generally stronger for males, younger patients (18–29 years) and whites, despite the strong predilection of the disease for women and nonwhites [1]. Our study further suggests that HS may be associated with DS in a not negligible proportion of patients.…”

“…Interestingly, a recent population-based cross-sectional study showed a 2.1% prevalence of HS among patients with DS, and a 5.24-fold higher risk (95% CI: 4.62–5.94) of DS patients being affected by HS [1]. In addition, the association was reported generally stronger for males, younger patients (18–29 years) and whites, despite the strong predilection of the disease for women and nonwhites [1].…”

“…Hidradenitis suppurativa (HS), also known as acne inversa or syndrome di Verneuil, is a chronic inflammatory, debilitating skin disease with an estimated prevalence in Europe and the USA varying from 0.1 to 4% [1-4]. Clinically, typical lesions are painful, deep-seated, inflamed nodules and abscesses, sinus tracts, and scarring, located on the body areas rich in apocrine glands such as the axillae, inguinal, and anogenital regions.…”

The clinical, biochemical, and ultrasonographic characteristics of patients with hidradenitis suppurativa in Northern Peninsular Malaysia: a multicenter study

“…had an earlier age of onset. Garg et al . documented that there was a 5‐fold increased odds ratio of HS among Down syndrome patients.…”

“…documented that there was a 5‐fold increased odds ratio of HS among Down syndrome patients. The potential genetic link predisposing Down syndrome patients to HS was because of an increased expression of the gene encoding amyloid precursor protein (APP) located on chromosome 21 . As APP plays a role in stimulating keratinocyte adhesion, migration, and proliferation, Down syndrome patients are predisposed to keratinocyte hyperproliferation and follicular plugging and thus development of HS.…”