Prevalence of <i>Mycoplasma genitalium</i> among HIV-infected men in São Paulo city detected by realtime polymerase chain reaction

Costa, F.M.; Silva, R C da; Arruda, Liã Bárbara; Montanheiro, Patrícia; Duarte, Alberto José da Silva; Casseb, Jorge

doi:10.1258/ijsa.2009.008494

Cited by 12 publications

(14 citation statements)

References 18 publications

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“…This result was different from the result of da Costa et al 13 study that found HIV male patients with positive M. genitalium often practice oral sex (38%).…”

contrasting

confidence: 96%

“…This result is different from that of the da Costa et al 13 study which revealed infection of M. genitalium in HIV positive males were most common in men who have sex with men (MSM), i.e. 77%.…”

contrasting

confidence: 87%

“…These results suggested that M. genitalium infections generally occur during sexually active ages. It was found by da Costa et al 13 that the average age of subjects with positive M. genitalium in HIV positive males was 43 years old. Gatski et al 10 revealed that the average age of the HIV positive females subjects who were positive for M. genitalium was less than 35 years old, which were the sexually active population.…”

Section: Discussionmentioning

confidence: 94%

“…The results of this study were not much different from previous studies. Research conducted by da Costa et al 13 14 conducted a study on urine samples of 100 males patients who visited the NGU HIV and STI clinic in Chandigarh India in 2010, i.e. 70 HIV-positive cases and 30 HIV-negative cases.…”

Section: Discussionmentioning

confidence: 99%

“…Studies among HIV positive patients in several clinics in Italy, Brazil, United States, and India have found that the prevalence rates of M. genitalium vary between 1% and 10%. 10,[12][13][14][15] There is no data on the prevalence M. genitalium in HIV positive patients in Indonesia, especially in West Java. The examination and treatment of M. genitalium infection in high-risk populations should be investigated as a potential strategy to prevent HIV.…”

mentioning

confidence: 99%

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Mycoplasma genitalium Infection Prevalence in Patients with Human Immunodeficiency Virus

Rasianti¹,

Dharmadji²,

Miliawati³

et al. 2014

ijihs

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Objective: To determine the prevalence of Mycoplasma genitalium (M. genitalium) infection in HIV positive patients by PCR examination in Teratai Clinic of Dr. Hasan Sadikin General Hospital, Bandung in order to reduce sexually transmitted diseases, especially M. genitalium infection in HIV positive patients. Methods:This study was a cross-sectional study with consecutive sampling methods. Eighty one HIV positive patients attending the Teratai Clinic of Dr. Hasan Sadikin General Hospital, Bandung were recruited to be the subjects of this study. All subjects underwent history taking, physical examination, and PCR examination for M. genitalium. Specimens were taken from cervical smear in females and first void urine in male. Results:The prevalence of M. genitalium based on the PCR examination in HIV positive patients attended to Teratai Clinic Dr. Hasan Sadikin General Hospital Bandung was 9%. Conclusions:Mycoplasmal infection identification based on PCR examination should be considered for routine screening test to reduce the incidence of sexually transmitted diseases in HIV positive patients. IntroductionMycoplama genitalium (M. genitalium) is the smallest bacterium, with a genome size of 580 kb , of the Mollicutes Class (Mollis:soft, Cutis:skin, in Latin) that is mainly found in human genital tract.1,2 Several studies have already shown that M. genitalium is a sexually transmitted organism that causes asymptomatic or non-gonococcal urethritis (NGU) in males as well as cervicitis, endometritis, pelvic inflammatory disease in females. 3-7Mycoplama genitalium infection can be detected through culture, serological, and polymerase chain reaction (PCR) examinations. The culture examination may take several weeks or even months to grow M. genitalium.Hence, it cannot be used as a routine diagnostic tool in every day practice. In the serological examination, cross reactions may occur between M. genitalium and M. pneumoniae due to some similar structures, thereby decreasing the specificity of the test. The PCR examination can detect the microorganism in samples collected from the reproductive tracts in a highly sensitive, accurate, and specific manner. This leads to a situation where PCR is the only reliable diagnostic tool for M. genitalium infection.8 Currently, the PCR examination to detect M. genitalium is available for research only and not available comercially. MethodsThis study was an observational study with cross sectional design. The subjects were 81 HIV positive patients who visited Teratai Clinic of Dr. Hasan Sadikin General Hospital Bandung who were taken in consecutive admission in July 2012. The HIV serostatus of the study population had already been determined and confirmed based on National HIV guideline in Teratai Clinic before this study. The inclusion criteria for this study were male and female HIV patients inTeratai clinic who were sexually active. Female patients who were having her menstrual period were excluded from this study. The study design was approved by the Research Ethics Commit...

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“…This result was different from the result of da Costa et al 13 study that found HIV male patients with positive M. genitalium often practice oral sex (38%).…”

contrasting

confidence: 96%

contrasting

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Mycoplasma genitalium Infection Prevalence in Patients with Human Immunodeficiency Virus

Rasianti¹,

Dharmadji²,

Miliawati³

et al. 2014

ijihs

View full text Add to dashboard Cite

show abstract

Sexually Transmitted Infections and Male Infertility: Old Enigma, New Insights

Kushwaha

Gupta

2017

Male Infertility: Understanding, Causes and Treatment

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Alarming incidence of genital mycoplasmas among HIV-1-infected MSM in Jiangsu, China

Wang

Chen

et al. 2013

Eur J Clin Microbiol Infect Dis

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Males who have sex with men (MSM) are considered at high risk of blood-borne and sexually transmitted infections (STIs), mainly due to the practice of unsafe sex, often combined with drug use and needle-sharing. A cross-sectional study was designed for the detection of genital mycoplasmas during the period from March 2009 to May 2010 in Jiangsu province. This work was approved by the Research ethics Committee of Jiangsu Centers for Diseases Prevention and Control (CDC), and written consent was obtained from all participants. In total, 243 human immunodeficiency virus-1 (HIV-1)-infected MSM were screened in this study. Over half of them reported a history of sexual activity with females (65.0 %), and 26.3 % reported a history of sexually transmitted diseases (STDs) other than HIV. 44.0 % of patients were in the first 2 years of their HIV infection, and 72.4 % were still in HIV progression. Of the 243 analyzed samples, all were positive for at least one kind of mycoplasma. The infection rates of Mycoplasma genitalium, M. fermentans, M. penetrans, and M. pirum were 25.5, 9.9, 2.5, and 18.5 %, respectively. The M. genitalium infection was associated with a history of sexual activity with females, and those who had sex with females showed higher infection rates. Six M. penetrans-positive patients were still in HIV infection progression and did not receive highly active antiretroviral therapy (HAART). Men who perform this particular behavior are at higher risk of Mycoplasma infections. Further molecular and epidemiological cohort studies with larger populations are needed in order to identify the role of Mycoplasma infections in HIV-1-infected MSM.

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Prevalence of Mycoplasma genitalium among HIV-infected men in São Paulo city detected by realtime polymerase chain reaction

Cited by 12 publications

References 18 publications

Mycoplasma genitalium Infection Prevalence in Patients with Human Immunodeficiency Virus

Mycoplasma genitalium Infection Prevalence in Patients with Human Immunodeficiency Virus

Sexually Transmitted Infections and Male Infertility: Old Enigma, New Insights

Alarming incidence of genital mycoplasmas among HIV-1-infected MSM in Jiangsu, China

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