Prevalence of lean type 2 diabetes mellitus in recently diagnosed type 2 diabetes mellitus patients

Chaudhary, Prateek; Laloo, Damiki; Ranabir, Salam

doi:10.4103/2230-8210.119645

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…However, GTT and euglycemic hyperinsulinemic clamp showed glucose intolerance and IR in both sexes with females displaying a more aggressive phenotype when compared to males. Clinical studies have shown the presence of lean diabetes in both males and females 5, 32 with around twice the rate of incidence in females in one cohort 32 . However, large scale multi-centric clinical studies need to be undertaken to validate these findings.…”

Section: Commentmentioning

confidence: 99%

Novel lean type 2 diabetic rat model using gestational low-protein programming

Selvanesan

Schutt

Balakrishnan

et al. 2016

American Journal of Obstetrics and Gynecology

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Background Type 2 diabetes in lean individuals is not well studied and up to 26% of diabetes occurs in these individuals. Although the cause is not well understood, it has been primarily attributed to nutritional issues during early development. Objective Our objective was to develop a lean type 2 diabetes model using gestational low protein programming. Study Design Pregnant rats were fed control (20% protein) or isocaloric low protein (6%) diet from gestational day 4 until delivery. Standard diet was given to dams after delivery and to pups after weaning. Glucose tolerance test was done at 2, 4 and 6 months of age. Magnetic resonance imaging of body fat for the females was done at 4 months. Rats were sacrificed at 4 months and 8 months of age and their peri-gonadal, peri-renal, inguinal and brown fat were weighed and expressed relative to their body weight. Euglycemic-hyperinsulinemic clamp was done around 6 months of age. Results Male and female offspring exposed to a low protein diet during gestation developed glucose intolerance and insulin resistance. Further, glucose intolerance progressed with increasing age and occurred earlier and was more severe in females when compared to males. Euglycemic hyperinsulinemic clamp showed whole body insulin resistance in both sexes, with females demonstrating increased insulin resistance compared to males. Low protein females showed a 4.5-fold increase in insulin resistance while males showed a 2.5-fold increase when compared to their respective controls. Data from magnetic resonance imaging on female offspring showed no difference in the subcutaneous, inguinal and visceral fat content. We were able to validate this observation by sacrificing the rats at 4 and 8 months and measuring total body fat content. This showed no differences in body fat content between control and LP offspring in both males and females. Additionally, diabetic rats had a similar body mass index to that of the controls. Conclusion LP gestational programming produces a progressively worsening type 2 diabetes model in rats with a lean phenotype without obesity.

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Section: Commentmentioning

confidence: 99%

Novel lean type 2 diabetic rat model using gestational low-protein programming

Selvanesan

Schutt

Balakrishnan

et al. 2016

American Journal of Obstetrics and Gynecology

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“…[3] The regional prevalence of underweight type 2 diabetic varied from 3.5% to 10% across India. [45678] Over the past decades, various epidemiological studies have shown that the pattern and profile of diabetes mellitus in India are different, as well as in certain developing countries of Asia and Africa as compared to the West. [9] While almost 80% of type 2 diabetes mellitus patients in India are nonobese, 60%–80% of those in the west are obese.…”

Section: Introductionmentioning

confidence: 99%

Body mass composition among underweight type 2 diabetes mellitus patients—A cross-sectional comparative study

Garg¹,

Dutta²

2019

Indian J Endocr Metab

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Background: Over the past decades, various epidemiological data have shown that the pattern and profile of diabetes mellitus in India are different. The present study was carried out with an aim to study body mass composition in underweight type 2 diabetics and to compare with the normal population. Materials and Methods: The cross-sectional comparative study was conducted between January 2015 and December 2016 and included 60 participants who were selected using the convenient sampling technique. Newly diagnosed patients with type 2 diabetes mellitus and BMI less than 18.5 kg/m 2 were considered for the study. Chi square test and Independent student t test were used for finding the statistically significant difference in proportions and between means, respectively; Pearson correlation coefficient was estimated for finding the linear association between two continuous variables. Results: No statistically significant difference was observed between the two groups in terms of age, waist-hip ratio, and BMI. Higher amount of fat mass and percentage were observed among the patients with diabetes as compared to that of the control group ( P value < 0.05). However, there was no statistically significant difference between the underweight and the control group patients ( P value > 0.05). A significant positive correlation was observed between HbA1c values and body fat mass values ( P value < 0.05). Conclusion: Underweight type 2 diabetic patients were found to have high body fat mass as compared to healthy controls and the HbA1C values of the study participants were found to be positively correlated with fat mass.

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“…In certain regions, particularly in Asian countries, the prevalence of the non-obese variant can constitute 60-80% of the total T2DM burden (Perry et al, 2012). Some studies indicate that these non-obese individuals face a higher risk of cardiovascular events compared to their obese counterparts, underscoring the need for a more comprehensive understanding of the pathophysiological mechanisms involved (Chaudhary et al, 2013). The simplified explanation for the pathophysiology of Type 2 Diabetes Mellitus (T2DM) has traditionally focused on the interplay between beta-cell dysfunction and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Lean Diabetes in West Bengal

Banerjee,

Das,

Paul

et al. 2024

eatp

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The prevalence of diabetes mellitus has increased exponentially over the past decade in India and globally. Much has been published on the characteristics of type 2 diabetes mellitus and its association with the epidemic of obesity. But relatively little is known about the incidence of lean diabetes, progression of disease and fate of the patients with low-normal body mass index. This study was conducted to determine the prevalence of lean diabetes among diabetic individuals of three districts of West Bengal [Kolkata, Hooghly and 24 Pgs (N)]. A cross-sectional survey was carried out in three districts of West Bengal during January 2022 to August 2022, among adults aged 30-69 years. All diagnosed T2DM patients within a period of 5 years were included in the study. Lean diabetes was defined as nonketotic diabetes mellitus with a body mass index (BMI) < 18.5 kg/m 2 . Among 66 subjects with diabetes, the proportion of lean diabetes was 14% (9 subjects) the mean age of lean diabetics is 48.50 ± 6.30. Total cholesterol, LDL cholesterol and triglyceride levels were found to be lower in lean diabetics as compared to diabetic individuals with BMI 18.5 -22.9 or BMI>23.0. Among the lean diabetics, tobacco use is very high (67%) as well as 50% of them are required insulin therapy. In conclusion, the prevalence of lean diabetes was high (14%) among the selected study population.

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Prevalence of lean type 2 diabetes mellitus in recently diagnosed type 2 diabetes mellitus patients

Cited by 6 publications

References 2 publications

Novel lean type 2 diabetic rat model using gestational low-protein programming

Novel lean type 2 diabetic rat model using gestational low-protein programming

Body mass composition among underweight type 2 diabetes mellitus patients—A cross-sectional comparative study

Prevalence of Lean Diabetes in West Bengal

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