Prevalence of long-term physical sequelae among patients treated with multi-drug and extensively drug-resistant tuberculosis: a systematic review and meta-analysis

Interventions to prevent post-tuberculosis sequelae: a systematic review and meta-analysis

“…These are the most common types of post-TB sequelae reported in previous systematic reviews and meta-analyses. 2 , 6 In the current systematic review, several classes of interventions such as pulmonary rehabilitation programs, adjunctive surgical resection, comprehensive nursing care, micronutrient supplementation, adjunctive therapy, cognitive-behavioural therapy, hepatoprotective agents, and close patient follow-up and monitoring for timely medical intervention (e.g., dose reduction, treatment cessation, or switching to less toxic alternatives) were evaluated for their effectiveness in preventing different types of post-TB sequelae. The results demonstrated that only a few of these interventions have effectively prevented post-TB sequelae, providing important evidence for informed decision-making in managing post-TB sequelae.…”

“… 5 Previous systematic reviews on the global burden of TB-related disability showed that the prevalence of respiratory function impairment among TB survivors ranges from 15% to 60%. 2 , 6 A modelling study has shown that nearly half of the global burden of morbidity and mortality related to TB is attributed to post-TB lung diseases. 7 …”

Deep learning for precise diagnosis and subtype triage of drug‐resistant tuberculosis on chest computed tomography

“…3 Extensively drug-resistant tuberculosis (XDR-TB), the most advanced subtype of DR-TB, 4 with less than half successful treatment and being more prone to long-term sequelae, is of great concern as well. 5,6 Consequently, DR-TB remains a substantial threat to public hygiene, and prompt diagnosis and optimal therapeutic strategy-making based on the susceptibility profiles of DR-TB are crucial for TB supervision. Thus far, culture-based phenotypic drug-susceptibility testing (DST) is indicated as the primary reference standard of drug resistance analysis but is technically difficult, requiring strict operation and quality management.…”

“…Moreover, approximately 25% of antimicrobial resistance‐related deaths are due to rifampicin‐resistant tuberculosis (RR‐TB) 3 . Extensively drug‐resistant tuberculosis (XDR‐TB), the most advanced subtype of DR‐TB, 4 with less than half successful treatment and being more prone to long‐term sequelae, is of great concern as well 5,6 . Consequently, DR‐TB remains a substantial threat to public hygiene, and prompt diagnosis and optimal therapeutic strategy‐making based on the susceptibility profiles of DR‐TB are crucial for TB supervision.…”

Global Burden of Disease Due to Rifampicin-Resistant Tuberculosis in 2020: A Mathematical Modelling Analysis

“…The greater toxicity of drugs included in RR-TB regimens can also cause long-term sequelae. A meta-analysis of data on tuberculosis survivors found greater lung impairment among individuals surviving multi-drug resistant (MDR) tuberculosis compared to individuals with drugsusceptible tuberculosis 14 , and high levels of impairment among MDR-TB survivors have been reported across a range of functional domains 16 .…”