Prevalence of pituitary cysts in children using modern magnetic resonance imaging techniques

Mahdi, Eman; Webb, Ryan L; Whitehead, Matthew T.

doi:10.1007/s00247-019-04479-1

Cited by 13 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most frequent sellar finding identified in our study was the presence of small cysts (14.8%), either at the junction of the anterior and posterior pituitary (11%) or along the posterior superior aspect of the sella (3.8%). The cysts at the junction of the anterior and posterior pituitary are typically described as pars intermedia/Rathke's cleft cysts, thought to arise from the ectoderm, and have been reported in up to 57% of children using modern high-resolution MRI [24]. Autopsy studies have reported the prevalence of Rathke's cleft cysts in 12-33% of adults [25].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Is Gadolinium Contrast Necessary for Pituitary MRI in the Evaluation of Pediatric Short Stature and Growth Hormone Deficiency?

et al. 2021

View full text Add to dashboard Cite

Introduction: Short stature is a common concern that necessitates pediatric endocrinology evaluation. Growth hormone deficiency (GHD) is a commonly considered etiology. Brain and pituitary magnetic resonance imaging (MRI) with gadolinium-based contrast agents (GBCAs) is the most widely used imaging in assessing patients with GHD. Given the significant strides made in MRI technology, the need for contrast material should be reassessed. Method: We performed a retrospective review of healthy patients with short stature and/or GHD who underwent brain and pituitary MRI with and without contrast to assess the added value of contrast administration. Results: 227/318 identified patients underwent growth hormone (GH) stimulation testing; 28 (12.3%) with normal GH response and 62 (27.3%) with severe GHD. We found a low incidence of sellar and suprasellar pathologies. When comparing noncontrast and contrast MRI, we found perfect agreement in detecting abnormal posterior pituitary bright spots (kappa:1.0) and substantial agreement in detecting pars intermedia cysts and posterior superior sellar cysts (kappa: 0.74 and 0.71, respectively). Initially, only moderate agreement was found in detecting infundibular abnormalities (kappa: 0.51), although a revised noncontrast MRI protocol with high-resolution 3D images enabled visualization of the infundibulum. Conclusion: The MRI evaluation of healthy patients with short stature and/or isolated GHD may be completed without the use of GBCAs. The slight overestimation of pituitary stalk interruption by noncontrast images can be overcome by adding newer high-resolution sequences.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Is Gadolinium Contrast Necessary for Pituitary MRI in the Evaluation of Pediatric Short Stature and Growth Hormone Deficiency?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…An MRI of the pituitary gland revealed the presence of a 6 mm mildly hypoenhancing focus in the anterior pituitary suggesting a microadenoma that are usually an incidental finding and not a classic cause of CPP (Pedicelli et al, 2014). The follow‐up MRI a year later showed a decrease in size of the hypoenhancing area and an oval cyst between the anterior and the posterior pituitary gland likely a Rathke's cleft cyst, which can be present in up to 57% of children (Mahdi et al, 2019). These cysts are thought to be incidental and rarely of any clinical significance (Teramoto et al, 1994).…”

Section: Case Report and Investigationsmentioning

confidence: 99%

A novel CHD3 variant in a patient with central precocious puberty: Expanded phenotype of Snijders Blok‐Campeau syndrome?

LeBreton

Allain

Parscan

et al. 2022

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Snijders Blok‐Campeau syndrome is an autosomal dominant genetic disorder first described in 2018, mostly associated with de novo variants in the CHD3 gene that affects chromatin remodeling. This syndrome is characterized by developmental delay, speech delay, and intellectual disability, but only about 60 affected individuals have been reported to date. We report a de novo likely pathogenic CHD3 variant (c.5609G > A; p. (Arg1870Gln)) in a young female presenting with features of Snijders Blok‐Campeau syndrome including speech delay, autism spectrum disorder, learning difficulties, characteristic facial dysmorphisms, and a feature not previously described in this syndrome, idiopathic central precocious puberty. Her puberty was controlled with monthly injections of a GnRH analogue. Targeted exome sequencing was negative for genes known to be responsible for central precocious puberty. Our case raises the possibility that variants in CHD3 gene may also result in central precocious puberty. Strengthening this association could expand the phenotypic spectrum of the Snijders Blok‐Campeau syndrome and should be included in multigene panels for precocious puberty.

show abstract

“…Kleine, bis 4 mm große Zysten sind bei Kindern ein häufiger, aber klinisch unbedeutender Befund [27]. Sowohl Rathke-Taschen-Zysten als auch Pars-intermedia-Zysten gehen aus embryonalen Residuen der Rathke-Tasche hervor.…”

Section: Zysten Der Sellaregionunclassified

Intra- und paraselläre Prozesse – eine Übersicht

Raab¹,

Gotz²

2020

Radiologie up2date

View full text Add to dashboard Cite

ZusammenfassungFunktionsstörungen der Hypophyse, Gesichtsfelddefekte und Augenbewegungsstörungen sind typische Leitsymptome bei Erkrankungen der Sellaregion. Die Diagnose der jeweiligen Erkrankung und die Therapieplanung sind unter Berücksichtigung der komplexen lokalen Anatomie häufig herausfordernd. Diese Übersichtsarbeit beschreibt Untersuchungsmethoden und typische Befundmuster, die eine Diagnose sowie die zielführende Therapieplanung erleichtern sollen.

show abstract

Prevalence of pituitary cysts in children using modern magnetic resonance imaging techniques

Cited by 13 publications

References 10 publications

Is Gadolinium Contrast Necessary for Pituitary MRI in the Evaluation of Pediatric Short Stature and Growth Hormone Deficiency?

Is Gadolinium Contrast Necessary for Pituitary MRI in the Evaluation of Pediatric Short Stature and Growth Hormone Deficiency?

A novel CHD3 variant in a patient with central precocious puberty: Expanded phenotype of Snijders Blok‐Campeau syndrome?

Intra- und paraselläre Prozesse – eine Übersicht

Contact Info

Product

Resources

About