Prevalence of Primary Open Angle Glaucoma in a Rural Adult Chinese Population: The Handan Eye Study

Liang, Yuan Bo; Friedman, David S.; Zhou, Qiang; Yang, Xiaohui; Sun, Lan; Guo, Li; Tao, Qiu Shan; Chang, Dolly S.; Wang, Ning Li

doi:10.1167/iovs.11-7472

Cited by 135 publications

(134 citation statements)

References 52 publications

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“…Similarly, the Beijing Eye Study and Handan Eye Study reported that the ratio of open-angle glaucoma to primary angle-closure glaucoma was 2.6:1 and 2:1, respectively. [15][16][17] The reasons for the discrepancies between the recent studies and the past investigation have been attributed to differences in the examination techniques, variations in the definition of glaucoma, and regional differences between the provinces of China, leading to variations in climate, lifestyle, and ethnic background. 6,7,11,12,15 In our A total of 181 right and 198 left eyes was missing mainly due to severe media opacity.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

Zhong

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We evaluated the prevalence of glaucoma in adults of the Bai Nationality populations in rural China. METHODS.A population-based survey of Chinese Bai Nationality aged ‡50 years from randomly selected block groups in southwestern China was conducted. Eligible persons were invited to local examination sites for a complete ophthalmic examination. Glaucoma was diagnosed using the International Society of Geographical and Epidemiological Ophthalmology Classification scheme.RESULTS. In the study, 2133 subjects (77.8% participation rate) were examined, with a crude prevalence of all glaucoma of 2.2% (95% confidence interval [CI] 1.6%-2.9%). Primary open angle glaucoma (POAG) was found in 1.0% of cases (95% CI 0.6%-1.6%) and primary angle-closure glaucoma (PACG) in 0.9% (95% CI 0.6%-1.4%). The prevalence of all glaucoma was significantly higher in older people and women. Mean intraocular pressure (IOP) was 16.17 6 3.74 mm Hg (97.5th and 99.5th percentiles, 24 mm Hg and 30 mm Hg, respectively). The mean vertical cup-to-disc ratio (VCDR) was 0.43 6 0.17 (97.5th and 99.5th percentiles 0.7 and 0.8, respectively). Unilateral blindness was found in 80% of PACG, compared to only 36.3% of POAG cases.CONCLUSIONS. Prevalence of POAG is similar to PACG in the ethnic Bai population living in rural southwestern China. PACG has a worse visual impairment and prognosis compared to POAG. (Invest Ophthalmol Vis Sci. 2012;53:3221-3225)

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Section: Discussionmentioning

confidence: 99%

The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

Zhong

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…These results concurred with those of most other studies. 3,6,7,[9][10][11]20,21 Secondary glaucoma was the most debilitating condition, with 14.3% of these participants being blind.…”

Section: Discussionmentioning

confidence: 99%

“…This unexpected finding needs confirmation. Some studies 6,7,10,[24][25][26][27] have suggested an association between myopia and an increased risk for POAG. In our study, we found no association between myopia and POAG.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Types of Glaucoma in an Urban Chinese Population

et al. 2015

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IMPORTANCE Glaucoma represents a major public health challenge in an aging population. The Tanjong Pagar Eye Study reported the prevalence and risk factors of glaucoma in a Singapore Chinese population in 1997, which established the higher rates of blindness in this population.OBJECTIVES To determine the prevalence and associated risk factors for glaucoma among Chinese adults in Singapore and to compare the results with those of the 1997 study. DESIGN, SETTING, AND PARTICIPANTS In a population-based survey of 4605 eligible individuals, we selected 3353 Chinese adults 40 years or older from the southwestern part of Singapore. Participants underwent examination at a single tertiary care research institute from February 9, 2009, through December 19, 2011. EXPOSURES All participants underwent slitlamp ophthalmic examination, applanation tonometry, measurement of central corneal thickness, gonioscopy, and a dilated fundus examination. MAIN OUTCOMES AND MEASURES Glaucoma as defined by the International Society of Geographical and Epidemiological Ophthalmology guidelines and age-standardized prevalence estimates computed as per the 2010 Singapore Chinese census. Blindness was defined as logMAR visual acuity of 1.00 (Snellen equivalent, 20/200 or worse).RESULTS Of the 3353 respondents, 134 (4.0%) had glaucoma, including primary open-angle glaucoma (POAG) in 57 (1.7%), primary angle-closure glaucoma (PACG) in 49 (1.5%), and secondary glaucoma in 28 (0.8%). The age-standardized prevalence (95% CI) of glaucoma was 3.2% (2.7%-3.9%); POAG, 1.4% (1.1%-1.9%); and PACG, 1.2% (0.9%-1.6%). In a multivariate model, POAG was associated with being older and male and having a higher intraocular pressure. Of the 134 participants with glaucoma, 114 (85.1%; 95% CI, 78.1%-90.1%) were not aware of their diagnosis. Prevalence (95% CI) of blindness caused by secondary glaucoma was 14.3% (5.7%-31.5%), followed by 10.2% (4.4%-21.8%) for PACG and 8.8% (3.8%-18.9%) for POAG. We could not identify a difference in the prevalence of glaucoma compared with the 3.2% reported in 1997 (difference, −0.04%; 95% CI, −1.2 to 1.2; P = .97). CONCLUSIONS AND RELEVANCEThe prevalence of glaucoma among Singapore Chinese likely ranges from 2.7% to 3.9%, with secondary glaucoma being the most visually debilitating type. We could not identify a difference compared with previous studies approximately 12 years earlier. We report a high proportion of previously undiagnosed disease, suggesting the need to increase public awareness of this potentially blinding condition.

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“…In addition, epidemiological studies have shown that the prevalence of NTG is much higher among the Asian populations. In the Handan Eye study, NTG accounted for 90% of patients with primary open angle glaucoma (POAG); the proportion might be even higher in the Japanese population, in which 92% of the patients with POAG were classified as NTG (Iwase et al, 2004;Liang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population

Sang

Jia

Zhao

et al. 2016

Sci. China Life Sci.

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Prevalence of Primary Open Angle Glaucoma in a Rural Adult Chinese Population: The Handan Eye Study

Cited by 135 publications

References 52 publications

The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study

The Prevalence and Types of Glaucoma in an Urban Chinese Population

Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population

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