Prevalence of Thyroid Dysfunction in Patients With Ménière's Disease

Brenner, Michael; Hoistad, Dick L.; Hain, Timothy C.

doi:10.1001/archotol.130.2.226

Cited by 31 publications

(36 citation statements)

References 29 publications

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“…This finding was confirmed by the lack of correlation between thyroid autoimmunity and the degree of hearing loss as assessed by PTA. As already mentioned, Brenner et al [36] have recently described the presence of hypothyroidism under treatment with thyroid hormone in 32% of MD patients, a percentage that rose to 50% in those aged over 50 years. In the current study seven of eight patients receiving L-T4 therapy (six with autoimmune thyroid disease) developed iatrogenic hyperthyroidism (five subclinical and two overt hyperthyroidism) without any association with the severity of MD.…”

Section: Discussionmentioning

confidence: 77%

“…In a recent retrospective case-control study, Brenner et al reported that treatment with L-T4 was significantly more frequent in patients with MD than in the normal control population [36]. Interestingly, although the reason for administering L-T4 therapy was not investigated, the authors postulated chronic autoimmune thyroiditis to be the main cause, because none of the patients referred to having undergone thyroidectomy.…”

Section: Discussionmentioning

confidence: 99%

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Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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SummaryVarious aetiopathological mechanisms have been postulated to be at the root of Menière's disease (MD), and some data suggest that there may be also an underlying autoimmune factor. In fact, Menière patients manifest certain characteristics that are typical of autoimmune involvement association of particular human leucocyte antigen haplotypes, the presence of antibodies against internal ear antigens. In this study, we evaluated the association between thyroid autoimmunity and MD in a non-selected group of patients. We recruited 50 consecutive MD patients and two groups as controls: group A, 82 healthy volunteers; and group B, 50 subjects suffering from acute unilateral peripheral vestibulopathy. All subjects were submitted to instrumental assessment of cochlear-vestibular function and analysis of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and antithyroglobulin antibody (Tg-Ab) in the blood. The prevalence of autoimmune thyroiditis in group B [6/50 (12%); 66·7% TPO-Ab and 33·3% Tg-Ab] was superimposable with the healthy controls [6/82 (7%); 66·7% TPO-Ab and 33·3% Tg-Ab]. In contrast, 38% of the MD patients (P = 0·0001 versus group A and group B) had significant autoantibody levels (68·4% TPO-Ab; 15·8% TPO-Ab + TR-Ab; 10·5% Tg-Ab; 5·2% TPO-Ab + Tg-Ab). Furthermore, 14% of the MD patients were hyperthyroid under l-thyroxine therapy, while no dysfunction was seen in the control groups. Overall, our data demonstrate a significant association between MD and thyroid autoimmunity, which suggests that an autoimmune factor is involved in the aetiopathogenesis of this disease. These findings suggest that it should be useful to submit MD patients to multi-disciplinary clinical investigation.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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show abstract

“…Haid et al [13] have described these as co-morbid factors related to age. Regular screening for thyroid dysfunction is required especially in the elderly age group [14].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Audio Vestibular Profile of Meniere’s Disease in a Tertiary Care Centre in India

Selvakumar

Balraj

Kurien

et al. 2011

Indian J Otolaryngol Head Neck Surg

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The aims of this study are to determine the frequency of patients presenting with Meniere's Disease(MD) in an Indian setting, using the American Academy of Otolaryngology-Head and Neck Surgery (AAO) diagnostic criteria, and to describe the clinical and audio vestibular profiles of these patients. The study was based on prospective case series design in the settings of a tertiary referral hospital. The study included all consecutive patients aged between 5 and 75 years presenting with the history of hearing loss, vertigo, tinnitus and or aural fullness as participants, satisfying inclusion and exclusion criteria for MD (AAO 1995) recruited over a 12 month period. Main outcome measures comprised the evaluation of epidemiological profile, clinical features, and results of audio vestibular investigations like Pure Tone Audiometry with and without glycerol, Impedance Audiometry, Electrocochleography (ECohG), Distortion Product Otoacoustic Emission and Electronystagmography (ENG). The results of the study are as follows: The frequency of MD was 15.6%, being commoner in males than females (2.6:1) and occurring more in the age group 40-49 years among males and 30-39 years among females. High frequency tinnitus was commoner than low frequency tinnitus. Extra tympanic ECohG had a positive predictive value of 76% for endolymphatic hydrops. ENG was useful for demonstrating canal paresis pattern of nystagmus in 61%. Indian patients with MD commonly present to tertiary care at the functional level scale of 3. The results of this study revealed that the frequency of MD is not as low in the Indian ENT setting as earlier believed. There is a high chance of missing cases in the routine ENT outpatient clinic setting unless a structured proforma incorporating the AAO 1995 diagnostic criteria is used.

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“…The possible association between AITD and MD has been postulated since over 30 years, although it is still a controversial issue. At the beginning of the 1980s, Kinney [1980] and Meyerhoff [1981] excluded a relationship between thyroid dysfunction and MD [Kinney, 1980;Meyerhoff et al, 1981]; however, Evans et al [1988] showed that antithyroid microsome antibodies occurred in 17% of 150 MD patients [Evans et al, 1988] and this association was recently confirmed [Brenner et al, 2004;Fattori et al, 2008]. Interestingly, Evans et al [1988] showed 2 or more positive serum autoantibody titers in 9.3% of MD patients, the commonest being antinuclear autoantibody (23.3% of patients).…”

Section: Introductionmentioning

confidence: 99%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

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Objective/Hypothesis: The aim of this prospective study is to evaluate the possible association between Ménière’s disease (MD) and autoantibodies. Methods: Fifty-five patients with definite MD (51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. Results: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects (23.6%) had 1 or more elevated serum autoantibody levels. Conclusions: Based on our data we speculate that there is a more than a chance association between MD and ‘autoimmunity’, thus suggesting a hypothetical role of the immune system in MD pathogenesis. In other words, a pathogenetic role of an ‘immune dysregulation’ in MD patients can be hypothesized.

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Prevalence of Thyroid Dysfunction in Patients With Ménière's Disease

Cited by 31 publications

References 29 publications

Possible association between thyroid autoimmunity and Menière's disease

Possible association between thyroid autoimmunity and Menière's disease

Clinical and Audio Vestibular Profile of Meniere’s Disease in a Tertiary Care Centre in India

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

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