Prevalence, pattern and determinants of radiographic hand osteoarthritis in five Russian community-based samples

Kalichman, Leonid; Li, L.; Batsevich, Valery; Malkin, Ida; Kobyliansky, Eugene

doi:10.1016/j.joca.2010.02.006

Cited by 21 publications

(16 citation statements)

References 28 publications

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“…A high prevalence of MCP OA has been found in rural communities from the former Soviet Union 14 15. The discrepancy between these and other populations (including Framingham) may be due to differences in disease-susceptibility genes or occupational/cultural lifestyles, as MCP OA has been associated with heavy labour 32.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Haugen

Englund²,

Aliabadi³

et al. 2011

Annals of the Rheumatic Diseases

415

316

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Objectives To describe the prevalence and longitudinal course of radiographic, erosive and symptomatic hand osteoarthritis (HOA) in the general population. Methods Framingham osteoarthritis (OA) study participants obtained bilateral hand radiographs at baseline and 9-year follow-up. The authors defined radiographic HOA at joint level as Kellgren–Lawrence grade (KLG)≥2, erosive HOA as KLG≥2 plus erosion and symptomatic HOA as KLG≥2 plus pain/aching/stiffness. Presence of HOA at individual level was defined as ≥1 affected joint. The prevalence was age-standardised (US 2000 Population 40–84 years). Results Mean (SD) baseline age was 58.9 (9.9) years (56.5% women). The age-standardised prevalence of HOA was only modestly higher in women (44.2%) than men (37.7%), whereas the age-standardised prevalence of erosive and symptomatic OA was much higher in women (9.9% vs 3.3%, and 15.9% vs 8.2%). The crude incidence of HOA over 9-year follow-up was similar in women (34.6%) and men (33.7%), whereas the majority of those women (96.4%) and men (91.4%) with HOA at baseline showed progression during follow-up. Incident metacarpophalangeal and wrist OA were rare, but occurred more frequently and from an earlier age in men than women. Development of erosive disease occurred mainly in those with non-erosive HOA at baseline (as opposed to those without HOA), and was more frequent in women (17.3%) than men (9.6%). Conclusions The usual female predominance of prevalent and incident HOA was less clear for radiographic HOA than for symptomatic and erosive HOA. With an ageing population, the impact of HOA will further increase.

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Section: Discussionmentioning

confidence: 99%

Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Haugen

Englund²,

Aliabadi³

et al. 2011

Annals of the Rheumatic Diseases

415

316

View full text Add to dashboard Cite

show abstract

“…MCP involvement is generally thought to be less common than other hand joints and to represent a secondary OA process such as calcium pyrophosphate deposition disease (CPPD) or hemochromatosis. However, as shown by several studies reporting the patterns of hand OA, MCP involvement is not infrequent in radiographic or ultrasonographic OA [6,30], with prevalence estimates ranging from 8% to 36% in Caucasian populations [9,31-33]. MCP rOA has been shown to be more common among African American compared with white women in one study [34].…”

Section: Discussionmentioning

confidence: 94%

Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis

et al. 2011

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IntroductionAlthough osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic OA (rOA) grades across multiple joint sites, representing both presence and severity, to quantify the burden of rOA.MethodsWe used cross-sectional data from the Johnston County Osteoarthritis Project. The sample (n = 2092) had a mean age of 65 ± 11 years, body mass index (BMI) 31 ± 7 kg/m2, with 33% men and 34% African Americans. A single expert reader (intra-rater κ = 0.89) provided radiographic grades based on standard atlases for the hands (30 joints, including bilateral distal and proximal interphalangeal [IP], thumb IP, metacarpophalangeal [MCP] and carpometacarpal [CMC] joints), knees (patellofemoral and tibiofemoral, 4 joints), hips (2 joints), and spine (5 levels [L1/2 to L5/S1]). All grades were entered into an exploratory common factor analysis as continuous variables. Stratified factor analyses were used to look for differences by gender, race, age, and cohort subgroups.ResultsFour factors were identified as follows: IP/CMC factor (20 joints), MCP factor (8 joints), Knee factor (4 joints), Spine factor (5 levels). These factors had high internal consistency reliability (Cronbach's α range 0.80 to 0.95), were not collapsible into a single factor, and had moderate between-factor correlations (Pearson correlation coefficient r = 0.24 to 0.44). There were no major differences in factor structure when stratified by subgroup.ConclusionsThe 4 factors obtained in this analysis indicate that the variables contained within each factor share an underlying cause, but the 4 factors are distinct, suggesting that combining these joint sites into one overall measure is not appropriate. Using such factors to reflect multi-joint rOA in statistical models can reduce the number of variables needed and increase precision.

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“…In our previous study [17], we found a significant difference in prevalence and severity of hand OA between five Russian samples (same ethnicity) living in different areas. Similarly, a study of the Chinese Han population showed that the prevalence of symptomatic and radiographic knee OA differs between South China and North China [10], with a much lower prevalence in South China.…”

Section: Discussionmentioning

confidence: 72%

Radiographic hand osteoarthritis in two ethnic groups living in the same geographic area

et al. 2010

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The aim of the study was to compare the prevalence of radiographic hand osteoarthritis (OA) and its association with age, sex, body mass index in two ethnic groups, Russian and Buryats who reside in the same geographic area. It was a cross-sectional observational study. The study population comprised ethnic Russians (N = 572) and Buryats (N = 327) from the Barguzinsky District of the Buryat Republic, Russian Federation. OA was evaluated in 14 joints of the left hand according to Kellgren and Lawrence's grading system. A diagnosis of OA was determined by the number of affected joints and by the presence of at least one affected joint. Statistical analyses included prevalence estimation, linear and logistic regressions, and chi(2) tests. Our major finding was that individuals of different ethnic groups, residing in the same location, have similar prevalence and severity of radiographic hand OA. Considering the results of our previous study, where we found significant differences in the prevalence and severity of hand OA between the Russian samples (same ethnicity) with diverse places of residence, we conclude that environmental factors play an important role in the development of hand OA.

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Prevalence, pattern and determinants of radiographic hand osteoarthritis in five Russian community-based samples

Abstract: Significant differences in prevalence and severity of hand OA were found between the Russian samples living in different geographic areas. Additional studies are needed to discover the mechanism defining the association between places of residence and development of hand OA.

Cited by 21 publications

References 28 publications

Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis

Radiographic hand osteoarthritis in two ethnic groups living in the same geographic area

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