Prevalence, severity and risk factors of allergic disorders among people in south India

Joseph, Nitin; Palagani, Revathi; Shradha, N H; Jain, Vaibhav; Kowshik, K; Manoharan, R; Nelliyanil, Maria

doi:10.4314/ahs.v16i1.27

Cited by 17 publications

(13 citation statements)

References 31 publications

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“…The common precipitants of allergic disorders include dust, seasonal changes, and food substances. 18 It is imperative to take a detailed history of allergy and exposure to various allergens while dealing with a case of HE/HES.…”

Section: Discussionmentioning

confidence: 99%

The Spectrum of Hypereosinophilia and Associated Clonal Disorders – A Real World Data From a Tropical Setting.

Sreedharanunni

Varma²,

Sachdeva

et al. 2018

Mediterr J Hematol Infect Dis

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ObjectiveTo determine the frequency, etiological spectrum and treatment outcome of hypereosinophilia (HE) and hypereosinophilic syndromes (HES) in a tropical setting.MethodsA retrospective analysis of hospital data of five years (January 2009 to December 2013) and a comprehensive prospective evaluation of patients presenting with HE/HES over a period of 33 months (January 2014 to September 2016) was performed.ResultsHE/HES was diagnosed in a total of 125 patients during the study period with an estimated prevalence of 0.5–1 case per 100,000 population in our hospital settings. 41 patients were excluded from the final analysis due to lack of sufficient data. Infections, especially helminths were the commonest cause (34%) followed by primary/clonal HE/HES (24%) and reactive HE/HES secondary to various clonal disorders (14.3%). A lymphocytic variant of HES and FIP1L1-PDGFRA positive HES were diagnosed in 3.6% each. Imatinib-responsive BCR-ABL1 negative HE/HES constitute 7.1% in our patients. None of the clinical or routine laboratory features including the age of patients, duration of HE, presence or absence of organomegaly, hemoglobin levels, eosinophil %, absolute eosinophil count, total leukocyte count, platelet counts, serum IgE levels or presence of myelofibrosis could predict or exclude malignancy in patients with HE/HES. The absence of blasts in peripheral blood or the absence of >5% blasts in bone marrow does not exclude primary/clonal HES.ConclusionsAn underlying malignancy (Primary HE/HES and neoplasms leading to reactive HES; 35.7%) is diagnosed with nearly equal frequency compared to infections (34.5%) in tropical settings. There are no hematological or serological parameters, which can reliably be used to exclude an underlying malignancy, necessitating a thorough follow-up and comprehensive work-up in patients with HE/HES.

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Section: Discussionmentioning

confidence: 99%

The Spectrum of Hypereosinophilia and Associated Clonal Disorders – A Real World Data From a Tropical Setting.

Sreedharanunni

Varma²,

Sachdeva

et al. 2018

Mediterr J Hematol Infect Dis

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“…Because of their high prevalence and high recurrence rate, allergic diseases pose a serious financial burden for affected households and consume substantial resources in socialized healthcare systems. Thus, the WHO has designated allergic diseases as one of the top disease classes requiring major research and prevention measures in the 21st century [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells

Chen

et al. 2018

Clin Transl Allergy

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Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators. Among them, IgE plays a vital role in the development of acute allergic reactions and chronic inflammatory allergic diseases, making its control particularly important in the treatment of IgE-mediated allergic diseases. This review provides an overview of the current state of IgE targeted therapy development, focusing on three areas of translational research: IgE neutralization in blood; IgE-effector cell elimination; and IgE+ B cell reduction. IgE-targeted medicines such as FDA approved drug Xolair (Omalizumab) represent a promising avenue for treating IgE-mediated allergic diseases given the pernicious role of IgE in disease progression. Additionally, targeted therapy for IgE-mediated allergic diseases may be advanced through cellular treatments, including the modification of effector cells.

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“…According to the reports of a study in India, the prevalence of allergy was 28.7% and the highest rate of allergy was associated with dust (21). Furthermore, the findings of another study indicated that the incidence rate of allergy was age-dependent such that the highest rate of allergy to mites and trees was observed in individuals above 4 years.…”

Section: Discussionmentioning

confidence: 98%

Study of respiratory allergens and associated factors in patients with allergic rhinitis referring to Imam Ali clinic in Shahrekord

Zamani

Alipour

Ahmadi

et al. 2019

J Shahrekord Univ Med Sci

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Background and aims: Respiratory allergens cause several problems for people with allergic rhinitis and are considered as a global challenge. This disease is an IgE-mediated nasal inflammatory disease that is triggered by the contact of the allergen. Therefore, this study was conducted to investigate respiratory allergens and associated factors in patients with allergic rhinitis who referred to a clinic in Shahrekord located in the southwest of Iran. Methods: In this cross-sectional study, 200 patients including 100 males and 100 females were enrolled using a convenience sampling technique. Diagnoses were made according to clinical symptoms and observation. In addition, the skin prick tests were used to detect the allergens. Finally, data were recorded and then analyzed by Stata. Results: Based on the results, 73.5%, 70.5%, 46%, and 43% of the patients were allergic to the following allergens including Dermatophagoid pteronyssinus, Dermatophagoides parinae, tree, and grass, respectively. Further, the mean height in the group with a positive and negative test for the inhaled allergens equaled 144.92±29.72 and 131.65±30.93, respectively, with a statistically significant difference (P<0.05). However, the mean weight, age, and the time at the onset of the disease were not significantly different between the two groups (P>0.05). Furthermore, the negative or positive reaction to the allergens failed to significantly differ with respect to gender, marital status, occupation, the county of residence, the area of residence, family size, and a family history of the disease (P>0.05). Conclusion: Allergic rhinitis is regarded as a common disorder among teenagers and young adults in this setting. Allergy to one or more respiratory allergens was found to be highly prevalent in patients with allergic rhinitis and the highest rate of allergy was observed to the mites, followed by tree and grass.

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Prevalence, severity and risk factors of allergic disorders among people in south India

Cited by 17 publications

References 31 publications

The Spectrum of Hypereosinophilia and Associated Clonal Disorders – A Real World Data From a Tropical Setting.

The Spectrum of Hypereosinophilia and Associated Clonal Disorders – A Real World Data From a Tropical Setting.

Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells

Study of respiratory allergens and associated factors in patients with allergic rhinitis referring to Imam Ali clinic in Shahrekord

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