Prevalencia de fragilidad y factores asociados en pacientes en programa de hemodiálisis

García-Cantón, César; Gálvez, Ana Ródenas; Aperador, Celia Lopez; Rivero, Yaiza; Diaz, Noa; Anton, Gloria; Esparza, Noemí

doi:10.1016/j.nefro.2018.07.012

Cited by 8 publications

(7 citation statements)

References 9 publications

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“…This study found a mean Charlson comorbidity index of 7 (± 2.09) for frail patients, which is higher than the one for non-frail patients (5.53 ± 2.32), p < 0.01. These results are consistent with those Garcia, et al described, a higher Charlson comorbidity index in frail versus nonfrail patients (7.9 versus 4.7, p < 0.001) 27 . Still, there are variations with the results of Rubio, et al in which they did not find differences between the Charlson comorbidity index for frail and non-frail patients (8.61 ± 1.28, versus, 8.39 ± 1.36, p 0.55) 28 .…”

Section: Comorbiditiessupporting

confidence: 93%

“…One of the topics of interest to future researches in frailty syndrome is to determine the existence of biomarkers that predict adverse outcomes on patients with endstage kidney disease and frailty syndrome. Garcia et al found a correlation of hypoalbuminemia with frailty, independently of the scale used to its diagnosis 27 . Moreover, Johansen, et al found a direct relationship between the severity of hypoalbuminemia and the risk of frailty syndrome 12 .…”

Section: Laboratory Testmentioning

confidence: 99%

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Frailty syndrome in patients with chronic kidney disease at a dialysis Centre from Santander, Colombia

Moreno-Useche

Urrego-Rubio

Sanabria

et al. 2021

JGG

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This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en CliniCal geriatriCs -Original investigatiOn

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Section: Comorbiditiessupporting

confidence: 93%

Section: Laboratory Testmentioning

confidence: 99%

Frailty syndrome in patients with chronic kidney disease at a dialysis Centre from Santander, Colombia

Moreno-Useche

Urrego-Rubio

Sanabria

et al. 2021

JGG

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“…Van Loon observed 67% frailty prevalence using the Groningen Frailty Indicator, although the study was conducted on an advanced-age population of 123 incident hemodialysis patients, all older than 65 years [26]. We have recently published our data for prevalent patients on hemodialysis measuring frailty using the Fried Phenotype Frailty Index and the EFS, where the proportion of frail patients was 41.2% when measured with the Fried criteria and 29.6% when measured with the EFS [27]. We chose the EFS because it can be easily administered in daily clinical practice and has been validated for different populations [9,[28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services

et al. 2019

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Background: Frailty is an aging-associated state of increased vulnerability, which raises the risk of adverse outcomes. Chronic kidney disease is associated with higher prevalence of frailty. Our aim was to estimate frailty prevalence in a hemodialysis population and its influence on shortterm outcomes. Design: Observational prospective longitudinal study of 277 prevalent hemodialysis patients. Frailty was estimated through the Edmonton Frail Scale (EFS). Demographic and clinical data, comorbidity index, and laboratory parameters were recorded. A 29-month follow-up was conducted on mortality, including hospitalization, and visits to hospital emergency services in the first 12 months of this period. Results: According to the EFS, 82 patients (29.6%) were frail, 53 (19.1%) were vulnerable, and 142 (51.3%) were non-frail. During follow-up, 58.5% frail patients, 30.2% vulnerable, and 16.2% non-frail ones died (p < .005). In the analysis of survival using an adjusted Cox model, a higher hazard of mortality was observed in frail than in non-frail patients (HR 2.34; 95% CI 1.39-3.95; p ¼ .001). During follow-up the hospitalization rate was 852 episodes/1000 patient-years for frail patients, 784 episodes/1000 patient-years for vulnerable patients, and 417 episodes/1000 patientyears for non-frail patients (p ¼ .0005). The incidence ratio of visits to emergency services was 3216, 1735, and 1545 visits/1000 patient-years for each group (p < .001). Conclusions: Hemodialysis patients present high frailty prevalence. Frailty is associated with poor short-term outcomes and higher rates of mortality, visits to hospital emergency services, and hospitalization.

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“…These observations agree with those of García et al . They described a higher Charlson comorbidity index in frail versus non-frail patients (7.9 vs 4.7; p<0.001) 17 . It contrasts with Rubio et al .…”

Section: Discussionmentioning

confidence: 96%

“…Numerous studies have found that hypoalbuminemia was correlated with frailty regardless of the scale used for its diagnosis 7 , 16 , 17 . In our study, lower levels of albuminemia were more common in frail patients (3.29 ± 0.61) as compared to non-frail patients (3.59 ± 0.54) with a statistically significant difference (p=0.0150).…”

Section: Discussionmentioning

confidence: 99%

Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center

Moreno,

Ruiz,

Urrego

et al. 2023

biomedica

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Introduction. Frailty syndrome generates a high risk of adverse outcomes and mortality, and its prevalence is elevated in patients with end-stage kidney disease. Few studies have reported the prevalence and outcomes of frailty in populations from less developed countries.Objective. To identify the clinical outcomes and factors associated with the frailty syndrome in patients with stage five chronic kidney disease who started renal replacement therapy – both hemodialysis and peritoneal dialysis– in a dialysis center in Bucaramanga, Colombia.Materials and methods. This was a prospective study of patients with end-stage kidney disease who initiated dialysis at a center in Colombia and had a twelve-month follow-up.Results. The overall frailty prevalence was 50.47% and two out of three patients older than 65 years had the syndrome. We found significantly higher followup mortality among patients with frailty: odds ratio of 2.95 (CI: 1.07- 8.13; p=0.036) in unadjusted analysis. Conclusions. Literature shows that compared to developed nations, Latin American adults are facing a higher prevalence of chronic diseases, and frailty syndrome is raising. In this study, according to the FRAIL scale, having a frailty syndrome predicts a higher mortality; hypoalbuminemia and low creatinine levels at the beginning of dialysis could act as predictors of its diagnosis.

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Prevalencia de fragilidad y factores asociados en pacientes en programa de hemodiálisis

Cited by 8 publications

References 9 publications

Frailty syndrome in patients with chronic kidney disease at a dialysis Centre from Santander, Colombia

Frailty syndrome in patients with chronic kidney disease at a dialysis Centre from Santander, Colombia

Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services

Frailty syndrome and end-stage kidney disease outcomes at a Latin American dialysis center

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