Prevalencia de hepatitis B y C en donadores de sangre en un hospital de tercer nivel de la ciudad de México

Méndez-Sánchez, Nahúm; Baptista-González, Héctor; Sánchez-Gómez, Raúl Hiramm; Bordes-Aznar, J.; Uribe, Misael

doi:10.1590/s0036-36341999000600007

Cited by 14 publications

(7 citation statements)

References 6 publications

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“…Several epidemiological studies of HCV performed in Mexican people that included blood donors, [28-30] open population, [31,32] and patients with cirrhosis [33] mentioned dental treatment as a probable risk factor. Other studies found that living with a family member infected with HCV [34,35] or suffering from liver disease [33,36,37] was an associated risk factor.…”

Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

et al. 2014

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BackgroundHepatitis C virus (HCV) is mainly transmitted by parenteral route, being blood transfusion and intravenous drug use the most frequent risk factors. However, it has been suggested that there are other routes of transmission. There are several studies where HCV RNA has been detected in saliva of patients infected with HCV, and epidemiological studies have proposed the dental treatments as possible risk factors for HCV transmission. The purpose of this study was to detect the presence of HCV RNA in saliva of patients with active infection and associating with periodontal or liver disease.MethodsPatients with quantifiable HCV-RNA in serum were enrolled in the study. Periodontal disease was assessed using the modified gingival index (MGI). Presence of dental plaque was assessed with the use of disclosing tablets. Patients were clinically and laboratory evaluated to identify the stage of liver disease, the HCV RNA was determinate in saliva by nested RT-PCR. To determine associations between different parameters univariate and multivariate analysis were used.ResultsA total of 45 patients were included. Of these patients, 21 (46.6%) had hepatitis, 23 (51.1%) had cirrhosis and one patient (2.4%) presented hepatocellular carcinoma (HCC). Viral loads in serum ranged from 2.31–6.68 log IU/ml with a mean of 5.46 log IU/ml (95% CI 5.23–5.70). HCV RNA was positive in saliva of 29 patients (64.4%) and was not detected in 16 (35.6%). For univariate analysis three independent variables were associated with the detection of HCV-RNA in saliva: gender, viral load and dental plaque and multivariate analysis only one independent variable viral load >5.17 log IU/mL remained significantly associated with the detection of HCV in saliva (p = 0.0002). A statistical difference was observed when viral load was analyzed, log 5.85 IU/mL (95% CI 5.67–6.02) for patients with HCV in saliva vs. log 4.77 IU/mL (95% CI 4.35–5.19) for patients without HCV in saliva (p = 0.0001). The detection of HCV-RNA in saliva was more frequent in patients with relatively high serum viral loads.ConclusionHCV-RNA in saliva was associated with the level of serum viral load but not with periodontal or liver disease severity.

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Section: Discussionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

et al. 2014

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“…Two of them presented data primarily of subjects from Mexico City and the state of Mexico, although it is mentioned that subjects were studied from Chiapas, Guanajuato, Guerrero, Hidalgo, Michoacan, Morelos, Oaxaca, Puebla, San Luis Potosi, Tamaulipas, Veracruz and Yucatan. 13,20 Only two studies included subjects from all states: a retrospective study presenting donor data obtained in 543 blood banks (5,857,946 donors) 33 which resulted in a prevalence of 0.67%, and a study based on information obtained from the National Health Survey, 51 which analyzed a random population sample of 21,271 subjects and reported a prevalence of 1.4%.…”

Section: Geographic Distributionmentioning

confidence: 99%

Prevalence of hepatitis C virus in the Mexican population: A systematic review

Santos‐López

Sosa-Jurado

Vallejo-Ruíz

et al. 2008

Journal of Infection

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“…23 Méndez-Sánchez y colaboradores publicaron un estudio transversal en el que se reportó una prevalencia de VHC de 0.47 y 0.11% para VHB de su población total (9,099 donadores) y se trató de un estudio en un hospital privado. 24 En este estudio se evidenció que el grupo etario de 25-44 años en ambos sexos fue el que más acudió a donar sangre. En lo general, predominó la causa por reposición (familiar) y únicamente 22 donaciones fueron altruistas; además, aportó referencias sobre el comportamiento de infecciones en la población del banco de sangre.…”

Section: Discussionunclassified

Prevalencia de hepatitis B y C en donadores de sangre de un hospital privado

Weber¹,

Greene²,

Zavala³

et al. 2020

Acta Médica Grupo Ángeles

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Infections caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), are global health issues and a serious risk associated to transfusional medicine; especially being one of the most important causes of liver damage in Mexico. Objective: To determine the prevalence of HBV and HCV in blood donors in Hospital Angeles Pedregal in a time lapse of 19 months. Material and methods: Retrospective and descriptive study carried out between the 1st of January 2018 and the 31st of July 2019, which included 5,705 donors. Results: Of 4,030 selected cases, 30.72% were female and 69.28% were male. We identified 22 altruistic donors and 4,008 for replacement of blood products. Global seroprevalence observed in our population was 0.27% for HCV and 0.04% for HBV. HVC infection was more frequent in females between 45 to 65 years, with three cases. Conclusions: A low prevalence of HBV and HVC infection was found, being 0.27% and 0.04%, respectively, HCV prevalence was found to be 5.5 times greater than HBV. These findings are probably explained because blood donors generally are healthy.

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Prevalencia de hepatitis B y C en donadores de sangre en un hospital de tercer nivel de la ciudad de México

Cited by 14 publications

References 6 publications

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

Detection of hepatitis C virus RNA in saliva of patients with active infection not associated with periodontal or liver disease severity

Prevalence of hepatitis C virus in the Mexican population: A systematic review

Prevalencia de hepatitis B y C en donadores de sangre de un hospital privado

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