Preventable contributors to the neonatal healthcare-associated infections: a uni-center analytical study from South India.

Abstract

Background: Globally, neonatal healthcare-associated infections (HAIs) are known to cause high mortality. HAIs is a preventable condition related to the healthcare environment. The current study explored the contributors to neonatal HAIs in one of the largest tertiary care referral hospitals in South India. Methods: Neonates from December 2016 to June 2018 were observed for the occurrence of healthcare-associated infections and compared with the matched control group. Various observations on neonatal demography, maternal contributors, and medical procedures were made and recorded to explore and analyse the contributors to neonatal HAIs. Univariate and multivariate analysis was carried out to find the contributors. The Odds ratio with 95% CI was also computed and reported. Results: Bloodstream infection (83%) was prevalent among neonates; the maternal contributor was only preterm labor (Odds ratio of 11.93; 95% CI; 6.47-21.98; p<.05) to acquire HAIs. On univariate analysis, mechanical ventilation for > 3days duration, NIV for > five days, and PICC line insertion procedure were significant (p<0.05) contributors to neonatal HAIs. IV cannulation for more than three times in four consecutive days was found in 100(85%) neonates considered being associated with neonatal HAIs. On multivariate analysis, NIV, PICC line, preterm labor, and low birth weight were significant (p<0.05) contributors to neonatal HAIs. Conclusion: The increased duration of invasive and non-invasive therapeutic devices and catheters contributes to neonatal HAIs. Neonates are acquiring bloodstream infections; low birth weight (LBW) neonates are more susceptible to acquiring HAIs.

Development and evaluation of prevention bundle for neonatal healthcare-associated infections: an interventional study

“…53,54 In the current study the prime contributors to HAIs among neonates, which were non-compliance to handwashing practices, equipment disinfection/cleaning, IV line insertion, many invasive procedures, and improper aseptic techniques. 55,56 Healthcare workers were identified as major contributors to HAIs similar to other published evidences. 57 As the number and frequency of observations and root cause analysis were highlighting improper hand hygiene practices & healthcare workers as one of the major contributors, reported by many, further investigation was carried out to find the areas of improvement.…”

The Risk of Neonatal Healthcare-Associated Infections at Three Teaching Hospitals in Rwanda

“…As regard to the neonatal outcome of the infected new-borns by HCAIs in the NICU, where 48% recovered and 52% died. [36,42] The maternal blood groups especially AB and O were statistically significant OR: 2.365, P: 0.028 and O.R:3.097,0.009 respectively. However in a cross sectional study conducted in University of Gondar comprehensive specialised hospital neonatal intensive care unit Northwest Ethiopia, maternal blood group were not considered in the social demographic characteristics of the mothers, [29] and in this study neonatal weight and gestational age were statistically significantly associated with HCAIs and similar results was found in a cross sectional study in Egypt and found a significant association between the occurrence of LBW and gestational age less than 37 weeks.…”