Preventing and Controlling Oral and Pharyngeal Cancer: Recommendations from a National Strategic Planning Conference

Squamous cell carcinoma is the most common head and neck malignancy. It can occur in the mandible or maxilla without a preexisting oral mucosal lesion. Often, the clinical and radiographic presentation of SCC directs the clinician to favour malignancy over other pathological conditions. However, SCC may also mimic an infectious condition and therefore can pose a diagnostic challenge even for the most experienced clinicians. Herein, we report a case of mandibular squamous cell carcinoma in a 53-year-old male who presented with symptoms of right facial swelling, trismus, pain, and right-sided lip paresthesia. The patient underwent a surgical removal of the presumed infected third molar of the right mandible, but histopathological analysis of the associated soft tissue unexpectedly yielded squamous cell carcinoma. Given the biopsy-proven diagnosis, the patient received a mandibular resection of the tumor followed by primary reconstruction with a fibular free flap. Patients presenting with symptoms mimicking odontogenic infections should receive vigilant attention by clinicians with regard to the disease history, clinical signs, radiographic evidence, and decision for histopathological analysis. This is especially true in the context of impacted dentition, where malignancy must be considered when formulating a differential diagnosis.

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Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells

Whyte

Al‐Hammadi

Balhaj

et al. 2010

Pharmacology

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Background and Purpose: The primary cannabinoids, Δ⁹-tetrahydrocannabinol (Δ⁹-THC) and Δ⁸-tetrahydrocannabinol (Δ⁸-THC) are known to disturb the mitochondrial function and possess antitumor activities. These observations prompted us to investigate their effects on the mitochondrial O₂ consumption in human oral cancer cells (Tu183). This epithelial cell line overexpresses bcl-2 and is highly resistant to anticancer drugs. Experimental Approach: A phosphorescence analyzer that measures the time-dependence of O₂ concentration in cellular or mitochondrial suspensions was used for this purpose. Key Results: A rapid decline in the rate of respiration was observed when Δ⁹-THC or Δ⁸-THC was added to the cells. The inhibition was concentration-dependent, and Δ⁹-THC was the more potent of the two compounds. Anandamide (an endocannabinoid) was ineffective; suggesting the effects of Δ⁹-THC and Δ⁸-THC were not mediated by the cannabinoidreceptors. Inhibition of O₂ consumption by cyanide confirmed the oxidations occurred in the mitochondrial respiratory chain. Δ⁹-THC inhibited the respiration of isolated mitochondria from beef heart. Conclusions and Implications: These results show the cannabinoids are potent inhibitors of Tu183 cellular respiration and are toxic to this highly malignant tumor.

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Preventing and Controlling Oral and Pharyngeal Cancer: Recommendations from a National Strategic Planning Conference

Cited by 7 publications

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Incidence rates and trends for oral and pharyngeal cancer in North Carolina: 1990–1999

Incidence rates and trends for oral and pharyngeal cancer in North Carolina: 1990–1999

An Unusual Case of Mandibular Squamous Cell Carcinoma in Intimacy with an Impacted Wisdom Tooth

Cannabinoids Inhibit Cellular Respiration of Human Oral Cancer Cells

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