Preventing lens epithelial cell migration using intraocular lenses with sharp rectangular edges

Nishi, Okihiro; Nishi, Kayo; Wickström, Kerstin

doi:10.1016/s0886-3350(00)00426-0

Cited by 202 publications

(143 citation statements)

References 10 publications

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“…7 These designs are pivotal in the prevention of PCO by preventing lens epithelial cell migration. 8 However, ray tracing techniques have indicated that there is greater internal light scattering onto the retina from the sharp IOL edges than those with rounded edges. 9 Recent works, which has realised the importance of the edge surface, have used a textured edge design of the Acrysof IOL with marked improvements in postoperative glare.…”

Section: Discussionmentioning

confidence: 99%

The effect of lens design on dysphotopsia in different acrylic IOLs

Shambhu

Shanmuganathan

Charles

2004

Eye

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Purpose To compare the incidence and severity of all grades of dysphotopsia in three types of acrylic intraocular lenses: the Acrysof MA30 BA and MA60 BM IOLs (Alcon) and the Akreos Fit one-piece IOL (Bausch and Lomb). Methods In all 111 patients were prospectively recruited who had undergone uncomplicated cataract surgery in the previous 12 months. Patients were assessed using a combination of a questionnaire and standardised provocation test, and were scored on a grading scale of 0-6 (0 indicating no glare and 6 indicating the most severe symptoms). Results The overall incidence of dysphotopsia was 77.7%. Patients with absent or mild symptoms (scoring 2 or less on the grading scale) were greater in the group implanted with the Akreos IOLs (49/65 eyes, 75%) as opposed to (44/92 eyes, 48%) of the eyes implanted with Acrysof lenses. Patients with more marked symptoms of glare as judged by scores of 5-6 were uncommon, but more prevalent in the Acrysof lenses (12/92 eyes, 13%) compared to the Akreos lenses (3/65 eyes, 4.6%) respectively. Statistically the Mann-Whitney test showed that there was significantly less dysphotopsia with the Akreos lens when compared to the Acrysof MA30 (P ¼ 0.005) and MA60 lenses (P ¼ 0.002). Conclusion This study demonstrates that dysphotopsia symptoms are commonly seen in certain brands of Acrylic IOLs. However, differences in design (not only related to the edge) significantly reduce the incidence of moderate and severe grades of dysphotopic symptoms.

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Section: Discussionmentioning

confidence: 99%

The effect of lens design on dysphotopsia in different acrylic IOLs

Shambhu

Shanmuganathan

Charles

2004

Eye

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“…This general pattern ties in well with clinical data 18 ; the further delay with the Alcon AcrySof acrylic IOL can be attributed to the well-described barrier effect from the interaction of the capsule and the square edge of this IOL. 10 At day 28 (end point), low-power images revealed that the percentage coverage of the posterior capsule differed between the groups (see Fig. 6).…”

Section: Capsular Bag Modelmentioning

confidence: 94%

“…These designs are manufactured using a range of materials and are likely to influence the progression of PCO because of the physical association with the capsule, creating a barrier effect. 10 However, there remains a significant need to lower the need for capsulotomies, which place a strain on health care resources and cause inconvenience for patients. 11 However, it should not be assumed that a person who does not undergo corrective laser surgery has optimal vision.…”

mentioning

confidence: 99%

A Fully Human In Vitro Capsular Bag Model to Permit Intraocular Lens Evaluation

Dawes

Illingworth

Wormstone

2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To establish a fully human in vitro culture model with which to test the putative effects of intraocular lens (IOL) designs in preventing posterior capsule opacification (PCO) after cataract surgery. METHODS. A sham cataract operation was performed to prepare human capsular bags from donor lenses. In one capsular bag of a donor pair, an intraocular lens (PMMA round-edge IOL or acrylic IOL) was implanted while the other capsular bag remained aphakic. Bags were transferred to a Petri dish and secured anterior-face down using entomological pins. Capsular bags were maintained in Eagle's minimum essential medium supplemented with 2% human serum and 10 ng/mL TGF-␤ to drive growth and matrix contraction. RESULTS. In the absence of an IOL, cells appeared within the central posterior capsule at 4.38 Ϯ 0.26 days, whereas in the presence of a PMMA round-edge IOL or an acrylic IOL they appeared at 8 Ϯ 0.41 days and 11 Ϯ 0.7 days, respectively. Immunocytochemical analysis showed an accumulation of cells at the edge of the acrylic IOL and a less evident accumulation with the PMMA round-edge IOL. Moreover, matrix contraction was more prominent in the absence of an IOL but was still apparent, to a lesser degree, in the presence of a PMMA round-edge IOL. The acrylic IOL greatly suppressed matrix contraction. CONCLUSIONS. The authors have developed a fully human in vitro capsular bag system that relates well to clinical observations and permits the testing of novel intraocular lenses. (Invest Ophthalmol Vis Sci. 2012;53:23-29)

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“…17 In addition, a sharp posterior edge of the optic has been ascribed to reduce the PCO rate. 18 It is noteworthy that the two types of IOLs implanted in this study are made of acrylic material and both of them have sharp posterior optic edges.…”

Section: Discussionmentioning

confidence: 92%

Comparison of two acrylic intraocular lenses with different haptic designs in patients with combined phacoemulsification and pars plana vitrectomy

Mingels

Koch

Lommatzsch

et al. 2006

Eye

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Purpose The intra-and postoperative characteristics of two foldable single-piece intraocular lenses (IOL) with identical hydrophilic acrylic material, but different haptic designs (Akreos Adapt s and Akreos Fit s ), were compared in combined phacoemulsification and pars plana vitrectomy (PPV). Methods This was a prospective, randomized study in patients with simultaneous cataract and vitreoretinal surgery. Group A (n ¼ 47 patients) included implantation of Akreos Fit s IOL (two-point haptic) and group B (n ¼ 46 patients) implantation of Akreos Adapt s IOL (four-point haptic). All intraoperative modifications of small-incision phacoemulsification and three-port PPV and IOL implantation and centration were documented. At 1 and 2 days and 6 months after surgery, best-corrected visual acuity (BCVA), slit-lamp appearance (including inflammation, IOL centration, capsulorhexis diameter, posterior capsule opacification (PCO), tonometry, and fundus findings were evaluated. Results The groups did not differ with respect to age, surgical indications and modifications, intraoperative IOL handling, and centration. At day 2, inflammation and capsulorhexis diameters were similar, but IOL decentration was slightly more frequent with Akreos-Fit s IOLs. Six months after surgery, the rates of PCO, posterior synechiae, and BCVA were similar. Akreos-Fit s had slightly smaller capsulorhexis diameters and slightly more capsular contraction and IOL decentration (P40.05). Conclusions Both of the Akreos IOL are feasible for combined phacoemulsification and PPV. Although similar in intraoperative handling, BCVA, and PCO, IOL centration was slightly better with Akreos-Adapt s than with Akreos-Fit s after combined surgery.

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Preventing lens epithelial cell migration using intraocular lenses with sharp rectangular edges

Cited by 202 publications

References 10 publications

The effect of lens design on dysphotopsia in different acrylic IOLs

The effect of lens design on dysphotopsia in different acrylic IOLs

A Fully Human In Vitro Capsular Bag Model to Permit Intraocular Lens Evaluation

Comparison of two acrylic intraocular lenses with different haptic designs in patients with combined phacoemulsification and pars plana vitrectomy

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