Preventing long-lasting fear recovery using bilateral alternating sensory stimulation: A translational study

Wurtz, Hélène; Khoury-Malhame, Myriam El; Wilhelm, Frank H.; Michael, Tanja; Beetz, Eva Maria; Roques, Jacques; Reynaud, Emmanuelle; Courtin, Julien; Khalfa, S.; Herry, Cyril

doi:10.1016/j.neuroscience.2015.06.012

Cited by 26 publications

(34 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study findings replicate in humans the fear extinction facilitation by BLS previously found in mice (Wurtz et al, 2016). Even if the fear responses during fear extinction recall were not sensitive to BLS when assessed by the participants, their physiological responses showed a response modulated by BLS, as it did in mice.…”

Section: Discussionsupporting

confidence: 92%

“…As with mice (Wurtz et al, 2016), current BLS effect parallels what happened during EMDR therapy. That is, a decrease of the emotions related to a trauma event represented here by the fear of the electric shock memory.…”

Section: Discussionmentioning

confidence: 72%

“…PTSD’s underlying mechanism research commonly uses a fear conditioning and extinction paradigm in both human (Milad et al, 2006) and animal studies (Wurtz et al, 2016). This paradigm is based on a repetitive association between an aversive, US and a neutral CS, which leads to a conditioned fear response (LeDoux, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that PTSD patients had faster fear conditioning and slower fear extinction (Blechert et al, 2007; Wurtz et al, 2016), as well as a reduced extinction retrieval (Milad et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

“…It has alleviated early extinction and long-lasting fear recovery of conditioned fear in mice (Wurtz et al, 2016) thus suggesting that fear extinction associated with BLS could constitute a relevant animal model of mechanisms involved in EMDR therapy.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval

et al. 2017

View full text Add to dashboard Cite

Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval

et al. 2017

View full text Add to dashboard Cite

show abstract

Memory Trace for Fear Extinction: Fragile yet Reinforceable

Liu,

Ye,

et al. 2023

Neurosci. Bull.

View full text Add to dashboard Cite

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement, allowing the organism to re-adapt to ever-changing situations. Based on the behavioral hypothesis that extinction is new learning and forms an extinction memory, this new memory is more readily forgettable than the original fear memory. The brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain unclear. Intriguing questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction memory. In this review, we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction, aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

show abstract

Neural Circuits for Fear Relapse

Goode

Jin

2018

Neurobiology of Abnormal Emotion and Motivated Behaviors

View full text Add to dashboard Cite

Preventing long-lasting fear recovery using bilateral alternating sensory stimulation: A translational study

Cited by 26 publications

References 73 publications

Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval

Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval

Memory Trace for Fear Extinction: Fragile yet Reinforceable

Neural Circuits for Fear Relapse

Contact Info

Product

Resources

About