Preventing posterior capsule opacification by creating a discontinuous sharp bend in the capsule

Nishi, Okihiro; Nishi, Kayo

doi:10.1016/s0886-3350(99)80049-2

Cited by 228 publications

(114 citation statements)

References 10 publications

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“…The more effectively the optic edge blocked LEC migration, the narrower was the area that the LECs covered. These findings were consistent with results of clinical and pathological studies [18][19][20][21]. PCO in patients with sharp-edged IOLs is reportedly less severe than that seen with round-edged IOLs [18].…”

Section: Discussionsupporting

confidence: 92%

Inhibition of Lens Epithelial Cell Migration by an Acrylic Intraocular Lens in vitro

Kurosaka

Obasawa²,

Kurosaka³

et al. 2002

Ophthalmic Res

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We developed a new in vitro system to evaluate the effect of intraocular lenses (IOLs) on the migration of lens epithelial cells (LECs) and determined how acrylic and other IOLs influence LEC migration using this model. In an in vitro system, porcine LECs were cultured in a cell culture chamber insert, containing a collagen membrane, for 10 days with no IOL or with various types of IOLs. Migration of LECs beneath each IOL optic was observed with an inverted-phase microscope. The cell-free areas under the IOL optic, where the LECs had not migrated, were measured. Without IOL, LECs completely covered the collagen membrane within 5 days after plating (5.0 ± 0.0 days). Complete coverage was slowed by a silicone IOL (6.7 ± 1.2 days, p = 0.0305). LECs cultured with acrylic or with round- or sharp-edged polymethylmethacrylate (PMMA) IOLs did not completely cover the area. Ten days after initiating cultures, the cell-free areas under IOLs with sharp edges (acrylic, 41.1 ± 8.0%; sharp-edged PMMA, 60.9 ± 39.0%) were significantly larger than under IOLs with round edges (silicone, 0.0 ± 0.0%; round-edged PMMA, 1.5 ± 1.2%). A sharp edge may act as a barrier to LEC migration. Moreover, LEC migration under the acrylic IOL slowed after the LECs had crossed the barrier of the optic edge, perhaps due to acrylic adhesive properties. Only a few LECs reached the collagen membrane beneath the central 3 mm of the acrylic IOL. This new in vitro model was useful in evaluating the effect of various IOLs on LEC migration. Acrylic IOLs inhibited LEC migration by not only a sharp edge but also other factors, such as adhesive properties.

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Section: Discussionsupporting

confidence: 92%

Inhibition of Lens Epithelial Cell Migration by an Acrylic Intraocular Lens in vitro

Kurosaka

Obasawa²,

Kurosaka³

et al. 2002

Ophthalmic Res

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“…The lens has square edges, which in the rabbit model can create a capsular bend at the optic edge and delay ingrowth of epithelium. 5,6 Professor David Apple has confirmed this also with the Centerflex  (personal communication, 24 March 2001). The relatively low index of refraction (1.46) and reflection coupled with the equiconvex design reduces the chance of debilitating photic imagery after surgery.…”

Section: Implant Designmentioning

confidence: 80%

The influence of implant design on accuracy of postoperative refraction

Percival

Vyas

Setty

et al. 2002

Eye

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Purpose To assess the degree of accuracy of postoperative refraction that may be achieved with modern techniques and a new lens of modern design. Methods Five hundred eyes underwent refraction at one week and one month following phacoemulsification and implantation of the Centerflex  lens (Rayner Intraocular Lenses Ltd style 570H). Results were compared with the target that had been computerised at the time of surgery, using the Hoffer Q formula for axial lengths less than 22.0 mm, the SRK-T for lengths greater than 24.5 mm and a mean of the two formulae for lengths between 22.0 and 24.5 mm. Statistical analysis used Fisher's exact and one way ANOVA tests. Results At one month 97% of refractions were within 1.0 D spherical equivalent (SE) of target and 81% within 0.5 SE. The mean absolute error was 0.37 ؎ 0.39 SD. 75.8% of all eyes achieved 6/12 unaided and 88.6% achieved 6/9 with correction. In only 1.2% the refraction between one week and one month had altered by 0.5 D or more. Conclusions The Centerflex  when combined with modern methods of power calculation, can be associated with a high degree of accuracy in postoperative refraction.

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“…The capsular bag maintains its shape and does not collapse, preventing the proliferation and migration of epithelial cells and thus posterior capsular opacification [4][5][6]. Other possible applications include the prevention of postoperative shrinkage of the anterior capsular opening as a result of fibrosis (capsulorhexis phimosis, capsule contraction syndrome) and late IOL decentration [7,8].…”

Section: Inroductionmentioning

confidence: 99%

Outcome of Capsular Tension Ring (CTR) Implant in Complicated Cataracts

Rai

Sahai²,

Kumar³

2015

JCDR

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Preventing posterior capsule opacification by creating a discontinuous sharp bend in the capsule

Abstract: The discontinuous sharp capsule bend created by the sharp optic edges in both IOL types appeared to induce contact inhibition of the migrating LECs. The preventive effect of an acrylic IOL on posterior capsule opacification may be design dependent.

Cited by 228 publications

References 10 publications

Inhibition of Lens Epithelial Cell Migration by an Acrylic Intraocular Lens in vitro

Inhibition of Lens Epithelial Cell Migration by an Acrylic Intraocular Lens in vitro

The influence of implant design on accuracy of postoperative refraction

Outcome of Capsular Tension Ring (CTR) Implant in Complicated Cataracts

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