Preventing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind Study

Arslan, M; Çiçek, Ramazan; Kalender, Hülya Üstün; Yılmaz, Hüseyin Oğuz

doi:10.1016/j.curtheres.2011.02.002

Cited by 38 publications

(29 citation statements)

References 32 publications

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“…Nausea and vomiting due to surgery and anesthesia are among the most common complications. The reported incidence of PONV after LC varies from 50 to 70% [7][8][9][10]. There are many researches for prevention and cure PONV, such as using gabapentin, dexamethasone, perphenazine and so on, they all have efficacy and some side-effects more or less [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

The Prophylaxis and Treatment with Ondansetron for Postoperative Nausea and Vomiting

Yu¹,

Li²,

Chuan-xin-Wu³

et al. 2015

Surgery Curr Res

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Objective: Postoperative nausea and vomiting (PONV) is the common complication of patients undergoing laparoscopic cholecystectomy (LC). Aim of this study is to determine the efficacy of ondansetron for PONV after LC and exploring the most effective time of using it. Methods: The clinic data of 120 patients with chronic cholecystitis (selected randomly from all the patients undergone LC at the Second Affiliated Hospital of Chongqing Medical University between 2012 and 2014) were analyzed retrospectively. The data were divided into three groups: the preoperative group (n=40), postoperative group (n=40) and control group (n=40). The preoperative group received 8 mg of ondansetron intravenously 30 minutes prior to the induction of anesthesia while the postoperative group received 8 mg of ondansetron intravenously when anaesthesia recovery, the control group received no antiemetic. The incidence of PONV and the adverse effects during the postoperative periods (48 hrs) were recorded in the data. If the PONV happened, the patients received 8mg of ondansetron intravenous again. Results: Significant differences were found between the preoperative group and postoperative group (preoperative: 27.5% vs. postoperative group: 10%) and the preoperative group and control group (preoperative: 27.5% vs. control group: 50%). To the PONV case, using ondansetron intravenous again about 88% got control. No clinically important adverse effects were noted. Conclusion: Administration of ondansetron is effective in the prevention and cure of PONV for LC. Late administration (anaesthesia recovery) is significantly more effective.

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Section: Discussionmentioning

confidence: 99%

The Prophylaxis and Treatment with Ondansetron for Postoperative Nausea and Vomiting

Yu¹,

Li²,

Chuan-xin-Wu³

et al. 2015

Surgery Curr Res

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“…The meta-analysis by Si et al (25) revealed that the combination of dexamethasone plus other antiemetic agents is more effective than the single antiemetics for preventing PONV after laparoscopic cholecystectomy. Also, the study by Arslan et al (17) showed that combined propofol with dexamethasone is more effective in preventing PONV than combination of propofol plus metoclopramide. Although, metoclopramide is the most commonly used drug to prevent PONV, the previously published data have been in favour of dexamethasone in this regard.…”

Section: Discussionmentioning

confidence: 99%

“…The severity of nausea/ vomiting was graded into 4 categories, scoring ranged from 0 (Without nausea) to 4 (Severe vomiting [continuous]). (17) In order to evaluate the severity of pain, Visual Analogue Scale (VAS) was used. VAS score ranges from 0 (no pain) to 10 (worst possible pain).…”

Section: Data Collectionmentioning

confidence: 99%

“…(16) Additionally, its prevalence varies up to 75% in laparoscopic cholecystectomy. (17) Selection of the preventive method against PONV should be based on safety, efficacy, patient's satisfaction and cost-benefit. Antagonists of dopamine, chlorpromazine and metoclopramide, anticholinergic, antihistamines and dimenhydrinate have been used in this regard, but they have their own advantages and disadvantages.…”

mentioning

confidence: 99%

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Efficacy of Single-Dose of Dexamethasone in Reduction of Pain, Nausea and Vomiting After Laparoscopic Cholecystectomy- A Randomised Controlled Trial

Emami¹,

Nikbakhsh²,

Nassab³

et al. 2018

jemds

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BACKGROUND Dexamethasone is an available and cheap drug and has low complications. There are not enough studies on antiemetic and analgesic effects of dexamethasone after laparoscopic cholecystectomy. The aim of this study was to assess the efficacy of single-dose of dexamethasone on Postoperative Pain (POP) and Nausea and Vomiting (PONV) in the patients undergoing laparoscopic cholecystectomy in northern Iran. MATERIALS AND METHODS This randomised controlled trial was conducted on 140 patients who were candidates for laparoscopic cholecystectomy. The subjects were randomly assigned into Group I (dexamethasone 8 mg) and Group II (normal saline 5 mL). Each group had 70 patients. The subjects were followed about POP and PONV every 4 hours for 12 hours after the operation using Nausea and Vomiting Scale (NVS) and Visual Analogue Scale (VAS) pain scores. RESULTS Seven patients (12.1%) were men and 123 (87.9%) were women. The mean age was 44.37 ± 8.69 years old. The mean NVS score was significantly different between the two groups in both periods 0-4 hours (Group I: 1.06 ± 0.85, Group II: 1.38 ± 1.00; p= 0.043) and 4-8 (Group I: 0.58 ± 0.24, Group II: 0.67 ± 0.29; p= 0.047) hours after the surgery. About VAS pain score, there were significant mean differences between the two groups in both periods 4-8 hours (Group I: 4.09 ± 1.01, Group II: 4.49 ± 1.24; p= 0.038) and 8-12 hours (Group I: 2.06 ± 0.81, Group II: 2.47 ± 1.16; p= 0.017) after the surgery. CONCLUSION According to the findings, single-dose of dexamethasone had a significant reducing effect on POP and PONV in the patients undergoing laparoscopic cholecystectomy.

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“…At high doses metoclopramide associated with extrapyramidal effects such as akethesia motor restlessness etc. 2,8 Rationale of this study is to compare the efficacy of ondansetron and metoclopramide in patients undergoing laparoscopic cholecystectomy under general anesthesia. Many studies have compared the efficacy of ondansetron and metoclopramide, however on reviewing the literature, it was noticed that there is contradiction about the efficacy between both drugs.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Ondansetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia.

Shuja¹,

Shah

Bokhari

2019

TPMJ

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Background: Laparoscopic cholecystectomy is a standard treatment for cholelithiasis. It is a safe and effective treatment in many cases. General anesthesia has a high incidence for PONV. But anti-emetic drugs can help in preventing PONV. Objectives: To compare the efficacy of ondansetron and metoclopramide in patients undergoing laparoscopic cholecystectomy under general anesthesia. Study Design: Randomized controlled trial. Setting: Department of Anaesthesia, Sheikh Zayed Hospital, Lahore. Period: 6 months i.e. from 15-2-2017 to 15-8-2017. Material & Methods: The patients were divided into two groups. Ondansetron was given to group A patients within 15 minutes of induction, and metoclopramide to group B patients within 15 minutes of induction. Then patients were shifted to the ward after surgery and followed-up for 24 hours for assessment of PONV. All the data was entered and analyzed on SPSS version 20. Results: The mean age of patients in group A was 38.40±12.07 years and in group B was 42.63±11.77 years. The efficacy achieved in 53 were from group A and 39 were from group B Statistically significant difference was found between the study groups i.e. p-value=0.003. Conclusion: Ondansetron showed significantly better efficacy than metoclopramide in preventing PONV after laparoscopic cholecystectomy under general anesthesia.

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Preventing Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind Study

Abstract: Administration of a subhypnotic dose of 0.5 mg/kg propofol plus 8 mg dexamethasone at the end of surgery was more effective than administration of 0.5 mg/kg propofol plus metoclopramide in preventing PONV in the early postoperative period in adult patients undergoing LC.

Cited by 38 publications

References 32 publications

The Prophylaxis and Treatment with Ondansetron for Postoperative Nausea and Vomiting

The Prophylaxis and Treatment with Ondansetron for Postoperative Nausea and Vomiting

Efficacy of Single-Dose of Dexamethasone in Reduction of Pain, Nausea and Vomiting After Laparoscopic Cholecystectomy- A Randomised Controlled Trial

Comparison of Ondansetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia.

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