Prevention: Activity is the best medicine

DeWeerdt, Sarah

doi:10.1038/475s16a

Cited by 40 publications

(35 citation statements)

References 9 publications

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“…55,56 However, recent developments at the interface between bioinorganic chemistry and neuroscience have opened the door for appealing new targets relating to zinc homeostasis, to be discussed in this review.…”

Section: Risk Factorsmentioning

confidence: 99%

“…56 Many such compounds are found as natural products or well-known drugs for other purposes and can be obtained as part of a diet. 860−863 In addition to being antioxidant and metal-chelating with the optimal K d and selectivity between targeted metal ions, these compounds should also be hydrophobic and capable of crossing the BBB and must be of reasonable small molecular weight and fulfill various other, typical criteria of druglikeness.…”

Section: Natural Metal Chelators Againstmentioning

confidence: 99%

“…56,57 Some factors may correlate with but not cause disease progression: For example, education is a key component of an active cognitive life style that may reduce risk of AD, 57,58 but education may correlate with other factors such as dietary intake. Distinguishing correlation and causation is thus central also to AD research.…”

Section: Risk Factorsmentioning

confidence: 99%

“…290 Various genetic risk factors become active at various stages of life, some possibly during early CNS development 729 (presenilin may have a role in fetal neurogenesis 988 ) and some from later brain trauma 7 or chemical exposure [41][42][43]47 and may lead to initiation of the spiral cascade in Figure 15. 4,32 (2) Life-style-related risk factors such as antioxidant deficiency, 55 obesity, 35,36 hypercholesterolemia, 39,40 passivity, 57,61,56 and smoking 34,772 may aggravate these risk factors by challenging metabolic networks, the already weakened stress response, and overall neuronal capacity. They all relate to metal ion dyshomeostasis, notably via zinc, as discussed in section 7.…”

Section: −52mentioning

confidence: 99%

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Bioinorganic Chemistry of Alzheimer’s Disease

2012

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Section: Risk Factorsmentioning

confidence: 99%

Section: Natural Metal Chelators Againstmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Section: −52mentioning

confidence: 99%

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Bioinorganic Chemistry of Alzheimer’s Disease

2012

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“…Moderate exercise has been demonstrated to be useful in the prevention of primary and secondary diseases, including cardiovascular diseases (27), type II diabetes (28), metabolic syndrome (29) and neurodegenerative diseases, such as Alzheimer's (30,31). The term hormesis has been proposed to explain the phenomenon of surviving exposure to small concentrations of toxic substances and adapting to them (32).…”

Section: Res and Exercisementioning

confidence: 99%

Resveratrol and exercise

2016

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Abstract. Although it is recommended for a healthy lifestyle, moderate exercise is known to lead to oxidative stress, inflammation and muscle injury. Hence there are efforts to develop dietary strategies to counter the oxidative stress caused by physical activity. Recently, there has been an interest in the capability of resveratrol (RES) to modulate physical performance and prevent oxidative stress. Despite the inconsistency among reports regarding the topic, it has been suggested that RES delays fatigue by hindering lipid peroxidation. It is hypothesized that RES administration produces favorable effects on hepatic cell rejuvenation, exerts a regulatory effect on glucose metabolism, and preserves liver glycogen reserves that are diminished during physical activity. Consequently, there is a growing interest in the association between RES and exercise. The aim of the current review is to interpret the association between RES and exercise.

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Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?

et al. 2013

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Neurodegenerative diseases are amongst the leading causes of worldwide disability, morbidity and decreased quality of life. They are increasingly associated with the concomitant worldwide epidemic of obesity. Although the prevalence of both AD and PD continue to rise, the available treatment strategies to combat these conditions remain ineffective against an increase in global neurodegenerative risk factors. There is now epidemiological and mechanistic evidence associating obesity and its related disorders of impaired glucose homeostasis, type 2 diabetes mellitus and metabolic syndrome with both AD and PD. Here we describe the clinical and molecular relationship between obesity and neurodegenerative disease. Secondly we outline the protective role of weight loss, metabolic and caloric modifying interventions in the context of AD and PD. We conclude that the application of caloric restriction through dietary changes, bariatric (metabolic) surgery and gut hormone therapy may offer novel therapeutic strategies against neurodegenerative disorders. Investigating the protective mechanisms of weight loss, metabolic and caloric modifying interventions can increase our understanding of these major public health diseases and their management.

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Prevention: Activity is the best medicine

Cited by 40 publications

References 9 publications

Bioinorganic Chemistry of Alzheimer’s Disease

Bioinorganic Chemistry of Alzheimer’s Disease

Resveratrol and exercise

Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?

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