Prevention and Control of Swine Enteric Coronaviruses in China: A Review of Vaccine Development and Application

Kong, Fanzhi; Jia, Huilin; Xiao, Qi; Fang, Liurong; Wang, Qiuhong

doi:10.3390/vaccines12010011

Cited by 5 publications

(2 citation statements)

References 139 publications

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“…1 Porcine transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus (PDCoV) induce diarrhea in piglets and sows, resulting in high mortality rates among neonatal piglets. 2 Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging virus that first appeared in southern China in 2017, leading to significant mortality among suckling piglets. 3 Furthermore, the ongoing coevolution of CoVs and their hosts driven by mutation and adaptation suggests that there is a possibility that livestock-or companion-animalspecific viruses could cross the host−species barrier and be transmitted to people in the future.…”

Section: ■ Introductionmentioning

confidence: 99%

“…They pose a significant challenge to livestock industry and community health, leading to severe economic issues . Porcine transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine deltacoronavirus (PDCoV) induce diarrhea in piglets and sows, resulting in high mortality rates among neonatal piglets . Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging virus that first appeared in southern China in 2017, leading to significant mortality among suckling piglets .…”

Section: Introductionmentioning

confidence: 99%

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Anti-Coronavirus Potential of Polyether Ionophores: The New Application of Veterinary Antibiotics in Livestock

Zheng,

Feng,

et al. 2024

J. Agric. Food Chem.

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Coronaviruses have consistently posed a major global concern in the field of livestock industry and public health. However, there is currently a lack of efficient drugs with broad-spectrum antiviral activity to address the challenges presented by emerging mutated strains or drug resistance. Additionally, the method for identifying multitarget drugs is also insufficient. Aminopeptidase N (APN) and 3C-like proteinase (3CLpro) represent promising targets for host-directed and virus-directed strategies, respectively, in the development of effective drugs against various coronaviruses. In this study, maduramycin ammonium demonstrated a broad-spectrum antiviral effect by targeting both of the proteins. The binding domains 4 Å from the ligand of both target proteins shared a structural similarity, suggesting that screening and designing drugs based on these domains might exhibit broad-spectrum and highly effective antiviral activity. Furthermore, it was identified that the polyether ionophores' ability to carry zinc ion might be one of the reasons why they were able to target APN and exhibit antiviral effect. The findings of this experiment provide novel perspectives for future drug screening and design, while also offering valuable references for the utilization of polyether ionophores in the management of livestock health.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%