Prevention and Management of Viral Hepatitis in Pregnancy

Rac, Martha; Sheffield, Jeanne S.

doi:10.1016/j.ogc.2014.08.004

Cited by 30 publications

(23 citation statements)

References 78 publications

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“…In fact, the only treatment used in nonpregnant populations to assist viral clearance, ribavirin with or without pegylated interferon, is specifically contraindicated during pregnancy . As a result, the main treatment for HEV infection in pregnant women is merely supportive, making prevention the main goal …”

Section: Treatment and Preventionmentioning

confidence: 99%

“…82 As a result, the main treatment for HEV infection in pregnant women is merely supportive, making prevention the main goal. 83 There are 2 key factors to achieving successful prevention: sanitary measures and vaccination. Pregnant women travelling to endemic areas should follow strict food and water precautions such as washing hands frequently, avoiding any water that is not bottled, not adding ice cubes to beverages, and eating only fruits and vegetables if they have been thoroughly washed with safe water.…”

Section: Treatment and Preventionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis E and pregnancy: current state

Pérez‐Gracia

Suay-García

Mateos-Lindemann

2017

Reviews in Medical Virology

189

162

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Hepatitis E virus (HEV) is responsible for more than 50% of acute viral hepatitis cases in endemic countries. Approximately 2 billion individuals live in hepatitis E-endemic areas and, therefore, are at risk of infection. According to World Health Organization, HEV causes about 20.1 million infections and 70 000 deaths every year. In developing countries with poor sanitation, this disease is transmitted through contaminated water and is associated with large outbreaks, affecting hundreds or thousands of people. In developed countries, autochthonous cases of HEV have been increasingly recognized in the past several years. Hepatitis E virus typically causes an acute, self-limiting illness similar to other acute viral hepatitis, such as hepatitis A or B, with about 0.2% to 1% mortality rate in the general population. However, the course of hepatitis E in pregnancy is different than the mild self-constraining infection described in other populations. During pregnancy, HEV infection can take a fulminant course, resulting in fulminant hepatic failure, membrane rupture, spontaneous abortions, and stillbirths. Studies from various developing countries have shown a high incidence of HEV infection in pregnancy with a significant proportion of pregnant women progressing to fulminant hepatitis with a fatality rate of up to 30%. The present review will highlight new aspects of the HEV infection and pregnancy.

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Section: Treatment and Preventionmentioning

confidence: 99%

Section: Treatment and Preventionmentioning

confidence: 99%

Hepatitis E and pregnancy: current state

Pérez‐Gracia

Suay-García

Mateos-Lindemann

2017

Reviews in Medical Virology

189

162

View full text Add to dashboard Cite

show abstract

“…Prevention includes adherence to sanitary practices and active and passive immunoprophylaxis. 3 Universal vaccination for pregnant mothers is not recommended, 1,2,6 but vaccination is recommended for high-risk patients and mothers-those with chronic liver disease, those receiving clotting factors, those who use illegal drugs, and travelers to areas where HAV is endemic. Immune globulin is also available for postexposure prophylaxis.…”

Section: Preventionmentioning

confidence: 99%

“…HAV vaccines and immune globulin are safe in pregnancy. 3,6,7 Treatment Treatment of acute HAV in pregnancy is supportive because of its benign nature; few patients require hospitalization. 3 Pregnant patients with HAV can deliver vaginally, and breastfeeding is not contraindicated.…”

Section: Preventionmentioning

confidence: 99%

Update on viral hepatitis in pregnancy

Shao

Tibi

Wakim-Fleming

2017

CCJM

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Pregnant women with acute viral hepatitis are at higher risk of morbidity and death than pregnant women with chronic viral hepatitis. The risk of death is highest with acute viral hepatitis E, and the rate of transmission to the baby may be highest with hepatitis B virus (HBV) infection. Managing viral hepatitis in pregnancy requires assessing the risk of transmission to the baby, determining the gestational age at the time of infection and the mother's risk of decompensation, and understanding the side effects of antiviral drugs.

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“…De récents articles permettent de synthétiser la prise en charge spécifique pour chaque type d'hépatite [10,11]. Nous présentons ici les hépatites virales dites non alphabétiques à Herpesviridae pendant la grossesse, en détaillant pour chaque virus le mode de transmission, la spécificité pendant la grossesse ainsi que les complications foetales éventuelles.…”

Section: Introductionunclassified

Hépatites virales aiguës à Herpesviridae et grossesse : mise au point

Dochez

Ducarme

2015

La Presse Médicale

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Prevention and Management of Viral Hepatitis in Pregnancy

Cited by 30 publications

References 78 publications

Hepatitis E and pregnancy: current state

Hepatitis E and pregnancy: current state

Update on viral hepatitis in pregnancy

Hépatites virales aiguës à Herpesviridae et grossesse : mise au point

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