Prevention is Better than Cure: Antibiotic Resistance and Management of Infectious Diseases

Haque, Mainul

doi:10.31344/ijhhs.v4i2.179

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…A study form Tehran, reported that from the 99 MRSA isolates and the Susceptibility of MRSA isolates to linezolid and tigecycline suggests that these drugs may be have an important role in the treatment of infections caused by these multiresistant pathogens 8 . According to the Indian literature, it seems the impact of multidrug resistant MRSA is increasing over time; for example, 23.2% was reported by Manjula et al, (2007) Globally AMR is identified as the one of top public health for treating infectious diseases.9 One US study revealed that methicillin-resistant Staphylococcus aureus (MRSA) alone is more powerful to increase mortality level among peoples of the USA than emphysema, HIV/AIDS, Parkinson's disease and homicide combined 12 . Currently, the situation AMR is horrifying as almost all available antibiotics or antimicrobials for clinical use are resistant.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance rate of the Methicillin Resistant Staphylococcus aureus isolated from a university affiliated hospital in North Cyprus

Ahmad

Güvenir

Güler

et al. 2022

Bangladesh J Med Sci

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Background: Over the past 20 years, studies have indicated that the increasing spread of methicillinresistant Staphylococcus aureus (MRSA) demonstrates the need for adequate information about their epidemiology. This study was conducted in order to investigate the resistance rate of MRSA which were isolated from the Near East University (NEU) Hospital, North Cyprus. Methods: MRSA was isolated and identified by using selective media and the Phoenix BD 100 system (software version 6.01A) was used for antimicrobial susceptibility testing and identification. The antimicrobial susceptibility results were determined according to the Clinical and Laboratory Standarts Institute (CLSI) and the resistance rates of MRSA isolates to antibiotics were examined retrospectively. Results: The highest number of samples were from the departments of chest disease (24%) followed by dermatology (21.3%) and cardiology (18.7%). Out of 75 MRSA strains,; 29.7% from blood, 25.3% from wound, 14.7% from nasal swabs, 10.7% from aspiration fluids, 9.3% from sputum, 6.7% were from urine, 4.0% from IV catheters culture samples. All strains of MRSA were 94.7% sensitive to vancomycin and teicoplanin. Conclusions: The obtained results revealed that preventative measures should be implemented in order to minimize the bacterial resistance to antibiotics. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 101-104

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Section: Discussionmentioning

confidence: 99%

Antibiotic resistance rate of the Methicillin Resistant Staphylococcus aureus isolated from a university affiliated hospital in North Cyprus

Ahmad

Güvenir

Güler

et al. 2022

Bangladesh J Med Sci

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“…As cited from Haque 2020, antibiotic resistance conditions will get worse because almost no new antibiotics will soon appear on the market to fight antibiotic resistance. 6 Adequate therapy is required to prevent the onset of complications of acute rhinosinusitis into chronic rhinosinusitis. Where surgery is the only treatment to treat chronic rhinosinusitis and other complications that occur when an acute infection is not treated properly.…”

Section: Introductionmentioning

confidence: 99%

Effect of Moringa Leaf Ethanol Extract on Reduced Levels of Mda, TNF-α and Description of Inflammatory Cells in Rat Sinus Mucosa Model of Acute Rhinosinusitis

Wardani

Purwanto

DonoIndarto

et al. 2022

Bangladesh J Med Sci

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Background: Symptoms and signs of acute viral and bacterial rhinosinusitis that are not specific cause difficulties in diagnostic enforcement, causing difficulties in administering therapy, so often doctors provide antibiotic therapy on acute viral rhinosinusitis. Irrelevant antibiotics will cause frequent antibiotic resistance. Adjuvant therapy is required to prevent infections that continue to become chronic, shorten the duration of infection, and avoid unwanted complications. Moringa leaves (M. oleifera)contains antioxidant components that can help rebalance redox metabolism and reduce excess free radicals so as to prevent oxidative stress. Method: posttest only control group research design. Male strain Sprague Dawley white rat was maintained and treated at the Nutrition Laboratory of the Center for Food and Nutrition Studies of Gadjah Mada University (UGM). Mice were divided into 4 groups. Group 1: standard feed., group 2: standard feed and staphylococcus-induced aureus, group 3: standard feed, Staphylococcus aureus-induced given amoxicillin dose of 27 mg/day, group 4: standard feed, Staphylococcus aureus-induced was given amoxicillin dose of 27 mg/day and given (EEDK) 200 mg/KgBW/day. Data analysis Of Normality test using Shapiro-Wilk Test and homogeneity using Levene’s Test obtained results p>0.05. Then conducted One Way AnovaTest obtained p<0.05 and continued with post-hoc LSD test. The data is analyzed using SPSS 25.0 for Windows. Result: MDA test Anova obtained p value (Sig.) = 0.000 (p< 0.05), Post Hoc with LSD all groups (p-value) < 0.05, indicated a significant mean difference in average MDA levels among all groups. The lowest mean difference in MDA levels in group K with P3 was 0.92 pg/mL; while P1 with P3 has the largest average MDA rate difference of 7.47 pg/mL. TNF-α Anova test obtained p value (Sig.) = 0.000 (p< 0.05), Post Hoc with LSD of all groups (p-value= 0.000) < 0.05, there is a meaningful difference in the average level of TNF-α between all groups. The smallest average difference in TNF-α levels in group K with P3 was 0.31 pg/mL; while P1 with P3 has the largest average TNF-α rate of 5.01 pg/mL. Description of inflammation of the mucosa cavum rice and sinus K score 0; P1 score 3; P2 score 2; P3 score 1. Conclusion: Moringa leaf ethanol extract in this study can be used as adjuvant therapy because it can lower MDA and TNF-α levels in mice induced with Staphylococcus aureus along with amoxicillin standard therapy. Extract ethanol moringa leaves in this study can be used as adjuvant therapy because it can lower the score of inflammatory cells better than by only given standard therapy only Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 311-317

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Biosurfactant production by halophilic yeasts isolated from extreme environments in Botswana

Loeto

Jongman

Lekote

et al. 2021

FEMS Microbiology Letters

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Nine morphologically distinct halophilic yeasts were isolated from Makgadikgadi and Sua pans, as pristine and extreme environments in Botswana. Screening for biosurfactant production showed that Rhodotorula mucilaginosa SP6 and Debaryomyces hansenii MK9 exhibited the highest biosurfactant activity using Xanthocercis zambesiaca seed powder as a novel and alternative inexpensive carbon substrate. Chemical characterization of the purified biosurfactants by Fourier Transform Infra-Red spectroscopy suggested that the biosurfactant from R. mucilaginosa SP6 was a rhamnolipid-type whereas the biosurfactant from D. hansenii MK9 was a sophorolipid-type. The two biosurfactants exhibited antimicrobial activities against eight pathogenic bacteria and fungal strains (Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Micrococcus luteus, Cryptococcus neoformans, Candida albicans and Aspergilus niger). The sophorolopid-type biosurfactant was found to be the most potent among the antimicrobial drug resistant strains tested. The findings open up prospects for the development of environmentally friendly antimicrobial drugs that use an inexpensive source of carbon to reduce the costs associated with the production of biosurfactants.

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Prevention is Better than Cure: Antibiotic Resistance and Management of Infectious Diseases

Abstract: not availableInternational Journal of Human and Health Sciences Vol. 04 No. 02 April’20 Page : 75-78

Cited by 3 publications

References 32 publications

Antibiotic resistance rate of the Methicillin Resistant Staphylococcus aureus isolated from a university affiliated hospital in North Cyprus

Antibiotic resistance rate of the Methicillin Resistant Staphylococcus aureus isolated from a university affiliated hospital in North Cyprus

Effect of Moringa Leaf Ethanol Extract on Reduced Levels of Mda, TNF-α and Description of Inflammatory Cells in Rat Sinus Mucosa Model of Acute Rhinosinusitis

Biosurfactant production by halophilic yeasts isolated from extreme environments in Botswana

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