Preventive Effects of Ellagic Acid on Nucleus Tractus Solitarius Electrical Activity and Oxidative Stress Altered by Cerebral Global Ischemia/Reperfusion in Rat

Nejad, Khojasteh Hoseiny; Sarkaki, Alireza; Dianat, Mahin; Farbood, Yaghoob; Badavi, Mohammad; Gharib-Naseri, Mohammad Kazem

doi:10.1590/1678-4324-2017160264

Cited by 4 publications

(3 citation statements)

References 50 publications

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“…16,17 Antosianin dan tannin dapat mengurangi kerusakan biomolekul tubuh akibat proses oksidatif sehingga mampu memperbaiki tekanan darah pada sampel tikus hipertensi. 18 Berdasarkan hasil temuan diatas, peneliti berasumsi bahwa jus buah memiliki potensi yang cukup besar untuk digunakan sebagai terapi komplementer dengan sampel penelitian pasien hipertensi. Terapi yang mungkin aman dalam penggunaan jangka panjang dan dapat membantu menurunkan tekanan darah.…”

Section: Pendahuluanunclassified

Effectiveness of Fruit Juice as Complementary Therapy on Blood Pressure of Hypertension Patients : A Systematic Review of Randomized Controlled Trials

Mahendra,

Surudarma,

Wihandani

et al. 2022

eum

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Hypertension treatment can be helped through complementary therapies, one of which is fruit juices. This study aimed to systematically review the evidence from various study regarding the effect of fruit juices on blood pressure in hypertensive patients and the types of fruit juices that are proven to be effective in reducing hypertension.This study is systematic review. Literature searching was conducted in four electronic databases, namely CINAHL, EMBASE, Pubmed, and Sciencedirect with the phrase fruit juices AND (hypertension OR blood pressure). Studies obtained from searching will be selected based on a screening title and abstract, eligibility criteria, and assesment risk of bias. The results of the study obtained 21 final studies with RCT research designs that passed the screening with complete eligibility criteria. However, the studies with valid results only amounted to 8 studies. These data show that as many as 5 studies prove fruit juices can reduce blood pressure in hypertensive patients and 3 other studies have stated the opposite. Thus, it can be concluded that there is strong evidence that fruit juices has a significant effect on reducing blood pressure in hypertensive patients. Fruit juices that have been shown to be effective are orange juice and queen garnet plum juice

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Section: Pendahuluanunclassified

Effectiveness of Fruit Juice as Complementary Therapy on Blood Pressure of Hypertension Patients : A Systematic Review of Randomized Controlled Trials

Mahendra,

Surudarma,

Wihandani

et al. 2022

eum

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show abstract

“…Ellagic acid is a form of tannic acid group and it is a polyphenol compound that is naturallyfound in some fruit and medicinal plants; and it has antioxidant and anti-inflammatory properties; moreover, researchers proved that the EA protect the liver against valproic acid and carbon tetrachloride (CCl4) (5) . Furthermore, EA have the ability to act on electrophysiological activity against traumatic brain damage, and it has a role in neurodegenerative disease like Parkinson's disease (PD) (6) . Additionally, researchers reported that the EA can prevent several types of cancers/breast, skin, and other types; furthermore, it canincrease the antioxidant enzymes and -reduce the pro-inflammatory cytokines through different pathway such its effect on decreasing nuclear factor-kappa B (NF-κB) activity, effect on release the cytochrome c through the potentiate the mitochondrial membrane; and through these methods, which are followed by ellagic acid lead to increase the Caspase-3 and increases expression in the tumor suppressor protein (p21) and then activation of apoptosis and cell cycle regulation (7) .…”

Section: Introductionmentioning

confidence: 99%

Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis

Al-hoshary,

Munaf H. Zalzala

2023

IJPS

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The intestinal mucositis define as inflammation and ulceration in the gastrointestinal tract wall and in some case in the oral cavity these cause by treatment with antineoplastic drug like 5-fluorouracil and Irinotecan and other types of chemotherapeutics drugs , 5-Fluorouracil-induced intestinal mucositis (IM) is consider as one of the more common tumor issue .it cause series of undesirables symptoms like severe diarrhea ,abdominal pain , stomach uncomfortable and other. The aim of this current study to see how ellagic acid act to Attenuates 5-FU-Induced Intestinal Mucositis and Diarrhea in Mice . we induced the intestinal mucositis by injected the mice intraperitoneally in 5-fluorouracil about 50mg per kg daily for four days respectively and then assessment the IM by measurement the level of some antioxidant enzymes like SOD , and level of some pro-inflammatory cytokines (IL-6) and lipid peroxidation biomarker (MDA) and we note the difference in the histopathological scoring after administration the ellagic acid to the mice in two different dose (10mg and 5mg per kg) daily for ten days respectively and before the fluorouracil injection in one hour .pretreatment with ellagic acid specialized dose of 10mg per kg significant improvement in the level of antioxidant enzymes ,pro inflammatory cytokines ,lipid peroxidation biomarker and histopathologicaL score compared with 5-FU group, moreover the potential action of ellagic acid was further supported by histopathological examination. all these data suggest that the ellagic acid effective in protective from 5-FU-induced intestinal mucositis.

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“…Although some scientific studies have previously reported on EA-inhibiting lipid peroxidation, and EA's anti-inflammatory, antiproliferative, antiangiogenic, hyperglycemia inhibiting, and anticarcinogenic effects [25][26][27], little information is available on the use of brain metabolomics as a tool for analyzing the integral metabolites of fever with EA. Research is necessary to enable a rat brain metabolomics investigation of the pyrexia and the antipyretic anti-inflammatory effect of EA performed using Ultra-High-Performance Liquid Chromatography-Mass spectrometry (UPLC-MS).…”

Section: Introductionmentioning

confidence: 99%

The Potential Antipyretic Mechanism of Ellagic Acid with Brain Metabolomics Using Rats with Yeast-Induced Fever

Xie

Zhu

et al. 2022

Molecules

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Fever is caused by an increase in the heat production process when the body is under the action of a heat source or the dysfunction of the temperature center. Ellagic acid (EA) is a polyphenol dilactone that has anti-inflammatory, anti-tumor, and antioxidant activities. Male Sprague-Dawley rats were injected yeast to reproduce an experimental fever model (150 ± 20 g), and the rectal temperature and its change values were subsequently taken 19 h later; the excessive production of interleukin-1β (IL-1β) and prostaglandin2 (PGE2) induced by yeast was regulated to normal by EA administration. Rat brain metabolomics investigation of pyrexia and the antipyretic anti-inflammatory effect of EA was performed using Ultra-High-Performance Liquid Chromatography–Mass spectrometry (UPLC-MS). Twenty-six metabolites, as potential biomarkers, significantly altered metabolites that were found in pyretic rats, and eleven metabolites, as biomarkers of the antipyretic mechanism of EA, were significantly adjusted by EA to help relieve pyrexia, which was involved in glycerophospholipid metabolism and sphingolipid metabolism, etc. In conclusion, potential metabolic biomarkers in the brain shed light on the mechanism of EA’s antipyretic effects, mainly involving metabolic pathways, which may contribute to a further understanding of the therapeutic mechanisms of fever and therapeutic mechanism of EA.

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Preventive Effects of Ellagic Acid on Nucleus Tractus Solitarius Electrical Activity and Oxidative Stress Altered by Cerebral Global Ischemia/Reperfusion in Rat

Abstract: Cerebral ischemia commonly occurs when the blood flow to the entire brain or some part of the brain is disrupted. Global cerebral ischemia attenuates the nucleus tractus solitaries (NTS) EEG

Cited by 4 publications

References 50 publications

Effectiveness of Fruit Juice as Complementary Therapy on Blood Pressure of Hypertension Patients : A Systematic Review of Randomized Controlled Trials

Effectiveness of Fruit Juice as Complementary Therapy on Blood Pressure of Hypertension Patients : A Systematic Review of Randomized Controlled Trials

Assessment of ellagic acid action in 5-fluorouracil induced intestinal mucositis

The Potential Antipyretic Mechanism of Ellagic Acid with Brain Metabolomics Using Rats with Yeast-Induced Fever

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