Previous inflammation alters the response of the rat colon to stress

Collins, Stephen M.; McHugh, Kevin J.; Jacobson, Kevan; Khan, Islam Ullah; Riddell, Robert H.; Murase, Kunihiko; Weingarten, Harvey P.

doi:10.1016/s0016-5085(96)70012-4

Cited by 145 publications

(106 citation statements)

References 2 publications

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“…Three other animal models with potential relevance for IBS have been reported (2,5,15,62,64,72). Two of these models (2,62,64), as well as the model presented in the current report, share long-lasting stress sensitization as a key pathophysiological mechanism underlying altered colonic motility as well as colonic hyperalgesia.…”

Section: Comparison To Other Animal Models Of Prolonged Stress Sensitmentioning

confidence: 69%

“…However, IBS is a chronic disorder characterized by the absence of inflammatory changes in the gut mucosa. More recently, several potential IBS models have been reported, all of which mimic certain aspects of the human syndrome (2,15,62,72). They include an early life colon irritation model (2), an adult stress sensitization model (62), and an adult postinfection model in the rat (15) and in the mouse (72).…”

mentioning

confidence: 99%

“…More recently, several potential IBS models have been reported, all of which mimic certain aspects of the human syndrome (2,15,62,72). They include an early life colon irritation model (2), an adult stress sensitization model (62), and an adult postinfection model in the rat (15) and in the mouse (72). Although all of these models have greater face validity for IBS than the older acute inflammation models, they mimic only some aspects of the pathophysiological and pathogenetic features of the human syndrome.…”

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confidence: 99%

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Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Coutinho¹,

Plotsky

Sablad³

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

404

372

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Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am J Physiol Gastrointest Liver Physiol 282: G307-G316, 2002. First published October 3, 2001 10.1152/ajpgi.00240.2001.-This study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long-Evans dams and their male pups were reared under two conditions: 1) 180 min daily maternal separation (MS180) on postnatal days 2-14 or 2) no handling or separation (NH). At 2 mo of age, visceromotor responses to graded intensities of phasic colorectal distension (10-80 mmHg) at baseline as well as following acute 60 min water avoidance stress (WA) were significantly higher in MS180 rats. Both groups showed similar stress-induced visceral hyperalgesia in the presence of naloxone (20 mg/kg ip). MS180 rats had smaller stress-induced cutaneous analgesia in the tail-flick test compared with NH rats, with a residual naloxone-resistant component. MS180 rats showed an enhanced fecal pellet output following WA or exposure to a novel environment. These data suggest that early life events predispose adult Long-Evans rats to develop visceral hyperalgesia, reduced somatic analgesia, and increased colonic motility in response to an acute psychological stressor, mimicking the cardinal features of irritable bowel syndrome. irritable bowel syndrome; stress; analgesia; naloxone IRRITABLE BOWEL SYNDROME (IBS) is a disorder characterized by chronic abdominal pain and discomfort associated with alterations in bowel habits in the absence of a demonstrable pathology (67). Although IBS is likely a heterogeneous disorder in terms of etiology and pathophysiology, alterations in bowel habits are likely related to alterations in autonomic regulation of the gut, whereas symptoms of abdominal pain and discomfort are thought to involve additional changes in the perception of visceral events, in the form of visceral hyperalgesia or allodynia (46, 48). Additionally, in IBS patients without a concurrent diagnosis of fibromyalgia, visceral hypersensitivity is associated with a normal or diminished somatic pain sensitivity to noxious stimuli (13).Progress in the development of more effective therapies has been hampered due to the lack of animal models that mimic the key features of IBS, in particular the enhanced perception of visceral events. Many investigations have utilized acute inflammatory insults to the gut using agents such as glycerol, mustard oil, acetic acid, or zymosan to produce acute visceral hypersensitivity, thereby mimicking inflammatory bowel disorders. However, IBS is a chronic disorder characterized by the absence of inflammatory changes in the gut mucosa. More recently, several potential IBS models have been reported, all of which mimic certain aspects of the human syndrome (2, 15, 62, 72). They include an early life colon irritation model (2), an adult stress sensitization model (62), and an adult postinfection model in the rat (15) and in the mouse (72). Alt...

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Section: Comparison To Other Animal Models Of Prolonged Stress Sensitmentioning

confidence: 69%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Coutinho¹,

Plotsky

Sablad³

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

404

372

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“…Animal studies suggest that stress may enhance responsiveness to inflammatory stimuli in the gut, while inflammatory processes in the gut may influence behavior and brain function. [41][42][43][44] The close proximity of chronic inflammatory cells to enteric nerves in the mucosa 36,37 and muscularis externa 27 of patients with IBS, provides an interface for direct interaction between cells and the enteric nervous system. Potential mechanisms of immune activation in IBS that have been suggested include a previous episode of gastroenteritis, alterations in intestinal microflora, undiagnosed food allergies and genetic factors.…”

Section: Morphologic Changes and Pathophysiology Of Ibsmentioning

confidence: 99%

Histopathological alterations in irritable bowel syndrome

Kirsch

Riddell

2006

Modern Pathology

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Irritable bowel syndrome is a common disorder defined by a symptom complex including abdominal pain and altered bowel habit. The etiopathogenesis appears to be multifactorial and to involve altered gastrointestinal motor function, enhanced perception of visceral stimuli and psychosocial factors. More recently a role for mucosal immune activation has been suggested. Routine histologic examination reveals no mucosal abnormality in the majority of cases but quantitative histological, immunohistochemical and ultrastructural analyses reveal subtle morphologic changes involving lymphocytes, mast cells, enterochromaffin cells and enteric nerves. The recent appreciation of these changes has led to new hypotheses linking central and enteric nervous systems to immune processes. This review highlights the spectrum of morphologic changes that occur in irritable bowel syndrome, examines their relationship to the pathophysiology of irritable bowel syndrome and considers their relevance to daily pathology practice.

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“…Th is could constitute a common pathway through which a large array of luminal antigens, including GI pathogens ( 31 ), dysbiosis ( 32 ), and food components ( 8 ), lead to symptom generation. Studies in animal models have shown that mucosal infl ammation alters gut sensory-motor function ( 33,34 ) and that deeper layers of the gut wall, including muscle and nerves, actively participate in the infl ammatory response to luminal stimuli ( 33 ).…”

Section: Low-grade Inflammation In Ibs: Is Gluten a Trigger?mentioning

confidence: 99%

Can Gluten Contribute to Irritable Bowel Syndrome?

Verdú

2011

American Journal of Gastroenterology

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Functional gastrointestinal disorders are the most common gastroenterological problem in our society. Changes in gut function, including pain perception, motility, and intestinal permeability, and low-grade infl ammation have been described in patients with irritable bowel syndrome (IBS). The triggering factors for the described immunity and gut functional changes in patients with IBS are not completely understood. Similarly to post-infective IBS, some patients with IBS symptoms exhibit immunological evidence of gluten sensitivity but have no overt intestinal mucosal injury. They have symptoms that meet the diagnostic criteria for IBS and respond symptomatically to exclusion of gluten from the diet. Thus, gluten sensitivity may be involved in the pathogenesis of a subgroup of IBS patients. Unfortunately, there remain many unanswered questions regarding the mechanistic link between gluten sensitivity and functional gastrointestinal symptoms.

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Previous inflammation alters the response of the rat colon to stress

Cited by 145 publications

References 2 publications

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

Histopathological alterations in irritable bowel syndrome

Can Gluten Contribute to Irritable Bowel Syndrome?

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