Previous Preterm Birth and Current Maternal Complications as a Risk Factor of Subsequent Stillbirth

Abstract

properly cited.Purpose. To examine the association between previous preterm birth and the risk of stillbirth. Methods. This population-based retrospective cohort study analyzed live births and stillbirth records in Missouri (1989Missouri ( -1997. The main outcome of interest was stillbirth occurrence while the exposures were prior preterm birth. Adjusted odds ratios and 95% confidence intervals were computed using logistic regression. Results. Women who had a previous preterm birth have 63% increased odds of stillbirth in singleton pregnancies and 75% increased odds in twins as compared to those who did not have a preterm birth in a prior pregnancy (AOR = 1.63, 95% CI = 1.41-1.88 and AOR = 1.75, 95% CI = 1.20-2.56), respectively. The most significant risk factor for stillbirth in singleton pregnancies was uterine bleeding (AOR = 5.89, 95% CI = 5.13-6.76). In twin pregnancies, it was the condition hydramnios/oligohydramnios (AOR = 4.72, 95% CI = 3.70-6.02). Eclampsia was associated with a heightened risk of stillbirth in singletons (AOR = 2.45, 95% CI = 1.41-4.12), but not in twins (AOR = 0.96, 95% CI = 0.13-7.00). Black mothers were more likely than white to experience stillbirth (AOR = 2.10, 95% CI = 1.99-2.22 for singletons and AOR = 1.51, 95% CI = 1.27-1.79 for twins). Conclusion. Stillbirth is a vital public health issue and its etiology is not well understood. Previous history of preterm birth was found to be associated with future stillbirth. Targeted early medical and obstetric care and interventions among women with preterm birth history may potentially reduce the likelihood of stillbirth.

Clinical Phenotypes Associated With Preterm Births at Jaramogi Oginga Odinga Teaching and Referral Hospital in Kisumu County, Kenya

“…A finding supported by a study in Australia, which showed that having diabetics mellitus and hypertension prior to pregnancy were associated with increased risk for stillbirth with mixed results for preeclampsia and eclampsia which were both found to raise the risk for antepartum stillbirth (Ibiebele et al, 2017). Ibrahimou et al, (2015), in a study in USA, showed that antepartum stillbirth was associated with various conditions that included eclampsia, hypertension, diabetes, multiple gestations and placenta abruptions that often result into premature termination of pregnancy.…”

Determinants of stillbirth among reviewed perinatal deaths in Ethiopia

“…In general, multiple factors could result in stillbirth, which can generally be categorized as maternal, fetal, and facility-level factors (25). Congenital malformation, infection, gestational age, sex, and birth weight are the fetal factors related to stillbirth (26)(27)(28)(29)(30), while maternal health conditions before and during pregnancy, maternal age, maternal parity, history of ANC visit, mode of delivery, maternal education, wealth index, birth interval, previous history of stillbirth, fetal movement monitoring are the major maternal factors (31)(32)(33)(34)(35). On the other hand, factors such as intrapartum monitoring, clinical management, and capacity of diagnosis are some of the facility-level predictors of stillbirth (36).…”