Priapism – A Rare Presentation in Chronic Myeloid Leukemia: Case Report

Abstract

Priapism is a complication rarely seen in leukemia. We report a 19-year-old man presented with persistent painful erection of penis for over 24 hours at home. The patient had underwent immediate irrigation and decompression of priapism by urologist at emergency services of the hospital. This approach resulted in a flaccid penis later. During hospitalization, peripheral blood smear and bone marrow aspiration confirmed the diagnosis of chronic myeloid leukemia.

Priapism: A rare presentation of precursor B-Cell acute lymphoblastic leukemia

“…Priapism is abnormal persisting penile erection beyond or unrelated to sexual stimulation lasting more than four hours. [1][2][3][4] The most common cause of priapism in children is sickle cell disease (65%), followed by leukemia (10%), trauma (10%), idiopathic (10%), and pharmacologically induced (5%). 4 Priapism is seen in 1-5% of male patients with leukemia.…”

“…6 CML accounts for 50% of leukemic priapism. 2 Symptomatic hyperleukocytosis, which is also called leukostasis is due to abnormal aggregation of leukemic blasts in the capillaries of the microcirculation and may result in lifethreating complications due to impairment of blood flow and/or activation of endothelial wall resulting in tissue hypoxia. Expression of adhesion molecules on leukemic blasts and their response to chemotactic cytokines play an important role in the development of leukostasis.…”

Priapism as the initial sign in hematologic disease: Case report and literature review

“…Finally, MP treatment is based on anticoagulants, fibrinolysis, puncture-aspiration and vasoactive agents injection. At the end, surgery is reserved only if conservative therapy is unsatisfactory and in special conditions which is necessary a specific treatment of the underlying disease [ [5] , [6] , [7] , [8] , [9] ]. We state that this work has been reported in line with the SCARE criteria [ 34 ].…”

Priapism as A Warning Sign for Chronic Myeloid Leukemia

“…CML is a chronic myeloproliferative disorder associated with activating mutations in tyrosine kinases forming a BCR-ABL fusion gene, causing hyperproliferation of neoplastic myeloid progenitors [1,2] . The incidence of CML peaks in the fourth and fifth decades of life [3] .…”