Primary advanced pulmonary synovial sarcoma treated with a multidisciplinary approach

Kagawa, Yosuke; Kitaguchi, Souichi; Konishi, Hanae; Hashimoto, Kaori; Norihito, Osaki; Mizumoto, Tadashi; Nishino, Ryohei; Sugahara, Fumihiro

doi:10.1007/s13691-020-00399-2

Cited by 3 publications

(11 citation statements)

References 17 publications

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“…Its cytogenetic marker is T (X; 18) (p11; Q11) chromosomal translocation 23 . The SYT‐SSX fusion gene can be detected by reverse transcriptase polymerase chain reaction (RT‐PCR) or fluorescence in situ hybridization (FISH) 2,11 . In an analysis of 50 people with SS, it was found that the sensitivity, specificity, and negative predictive values of FISH for SS were 82%, 100%, and 75%, respectively 25 .…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of PPSS is no different from that of other sarcomas, and the overall 5‐year survival rate is 50%; 23 the long‐term prognosis is poor 47 . Patients with advanced SS have a survival time of 18–19.7 months; 11 the overall survival time (OS) of patients with advanced PPSS is generally less than one year because they are inoperable or have metastases 48 . Risk factors for poor prognosis include male, age over 20 years, incomplete resection, neurovascular invasion, extensive tumor necrosis, tumor maximum diameter over 5 cm, pathological mitosis (>9/10HPF), and SYT‐SSX1 variants 20,23,25 .…”

Section: Discussionmentioning

confidence: 99%

“…Radiofrequency ablation can be used as an alternative therapy for nonoperative patients 31 . Through sequential multimode therapy, including surgery, radiosurgery, eribulin, and pazopanib, the survival time of patients can be relatively prolonged 11 . Prazopanib is a potent and selective multitarget receptor tyrosine kinase inhibitor that blocks tumor growth and inhibits angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…It has been approved in Japan for treating soft‐tissue sarcoma and kidney cancer 50 . However, prazopanib can cause tumor necrosis and induce pneumonia or tension pneumothorax, exacerbating disease progression 11,51 . Until now, it has been reported that apatinib is effective for treating primary synovial sarcoma of the lung 48 and patients with advanced sarcoma 52 .…”

Section: Discussionmentioning

confidence: 99%

“…Some drugs (ezetimibe, pazopanib, apatinib, etc.) at present are in the clinical trial stages, which provide patients with more treatment options 11 . Notably, anlotinib, is an oral small molecule receptor tyrosine kinase (RTK) inhibitor, targeting fibroblast growth factor receptors (FGFR1, FGFR2 and FGFR3) and VEGFR1, VEGFR2/KDR, VEGFR3, PDGFR‐α, c‐Kit and Ret.…”

Section: Introductionmentioning

confidence: 99%

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Whole‐exome sequencing in primary pulmonary synovial sarcoma misdiagnosed as mesothelioma: A case report and literature review

Zhang

et al. 2023

Thoracic Cancer

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Synovial sarcoma is a highly malignant tumor that accounts for 10% of all soft tissue sarcomas. Primary pulmonary synovial sarcoma (PPSS) is extremely rare, and its prognosis is poor. A diagnosis is usually established after other primary lung malignancies or metastatic extrathoracic sarcomas have been excluded. Therefore, it is often misdiagnosed. In this study, we report the case of a 38-year-old woman who was misdiagnosed as having pleural mesothelioma and finally endured surgery to remove the tumor. The tumor showed SYT-SSX fusion transcripts and was diagnosed as PPSS after combining histopathological and immunohistochemical analyses. Finally, we determined some biomarkers through whole-exome sequencing (WES) to improve the diagnosis and treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Whole‐exome sequencing in primary pulmonary synovial sarcoma misdiagnosed as mesothelioma: A case report and literature review

Zhang

et al. 2023

Thoracic Cancer

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Primary pulmonary monophasic synovial sarcoma initially presenting with bloody pleural effusion: A case report and literature review

Yin,

Liu,

Xue

et al. 2024

Clinical Case Reports

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Key Clinical MessagePrimary pulmonary synovial sarcoma (PPSS) can originate from blood vessels of the bronchial wall, lung interstitium, and interstitial components, and accounts for 0.1%–0.5% of all primary lung malignancies, the most common symptoms are chest pain, cough, dyspnea, and hemoptysis.AbstractSynovial sarcoma (SS) is a rare malignant tumor of stromal origin, which accounts for approximately 8%–10% of all soft tissue sarcomas. Primary pulmonary synovial sarcoma (PPSS) can originate from blood vessels of the bronchial wall, lung interstitium, and interstitial components, and accounts for 0.1%–0.5% of all primary lung malignancies. Patient concerns: We report the first case of a 57‐year‐old man with bloody pleural effusion as an initial manifestation of PPSS in the middle lobe of the right lung diagnosed after surgery. Diagnosis: Chest computed tomography (CT) revealed a mass in the middle lobe of the right lung, which was pathologically diagnosed as a monophasic SS after surgical resection. Interventions: Ten days after preoperative closed chest drainage, a right thoracotomy was performed to remove the right middle lobe of the lung. Outcomes: The patient recovered smoothly and was discharged from the hospital without any other postoperative treatment. A follow‐up chest CT scan 7 months postoperatively revealed intrapulmonary recurrence with multiple metastases. Lessons: Monophasic PPSS of the lung may present with bloody pleural effusion as its first manifestation.

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Primary advanced pulmonary synovial sarcoma treated with a multidisciplinary approach

Cited by 3 publications

References 17 publications

Whole‐exome sequencing in primary pulmonary synovial sarcoma misdiagnosed as mesothelioma: A case report and literature review

Whole‐exome sequencing in primary pulmonary synovial sarcoma misdiagnosed as mesothelioma: A case report and literature review

Primary pulmonary monophasic synovial sarcoma initially presenting with bloody pleural effusion: A case report and literature review

Pazopanib

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