Primary Amoebic Meningoencephalitis

Abstract

Case Presentation A 9-year-old female with an unremarkable past medical history presented to a Tyler, Texas emergency department with a 7-day history of worsening frontal headache and bilateral lower extremity "aches." During the previous 4 days she had also experienced a cough, nasal congestion, and rhinorrhea. Her condition rapidly progressed to include an increasingly severe headache, photophobia, nonbloody emesis, neck pain, fever (103.6°F), irritability, and disorientation along with episodes of verbal outbursts, purposeless movements, and eye rolling. The patient underwent a lumbar puncture, and cerebral spinal fluid was analyzed with the following results: glu

Drugs used for the treatment of cerebral and disseminated infections caused by free‐living amoebae

“…Moreover, another simplified association using only 2 molecules, amphotericin B and rifampicin, named combination C PAM , has also been highlighted in the current work with higher efficiency compared with the combinations A PAM and B PAM : 38% for EDU value (Table 1). 59,[84][85][86][87][88][89][90][91][92][93][94][95][96][97][98] Therefore, the combination C PAM , which would be less toxic than the other combinations as it contains only two drugs, might also be recommended in PAM treatment, more probably at early stages of the pathology. Indeed, the celerity to give an accurate diagnosis during the pathology influences the complexity and the toxicity of the drug combination used.…”