Primary and Secondary Environmental Control Measures for Allergic Diseases

Cosme-Blanco, Wilfredo; Arce-Ayala, Yanira M.; Malinow, Iona; Nazario, Sylvette

doi:10.1007/978-3-030-05147-1_36

Cited by 2 publications

(21 citation statements)

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“…To date, eight cat‐origin allergens have been identified and registered through the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub‐Committee . Fel d 1, a secretoglobin, is the major cat allergen . (Table ) Although monosensitization to Fel d 1 is common, individuals sensitized to the cat allergens Fel d 2 (an albumin allergen) and Fel d 4 (a lipocalin allergen) are usually also sensitized to Fel d 1 .…”

Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

“…Many owners consider their cats part of the family . For these reasons, allergists' guidelines‐based recommendations to remove the cat from the home are often met with resistance …”

Section: Cat Allergies: a Common Problem With Consequences For Humansmentioning

confidence: 99%

“…Removing the cat from the home is the most commonly recommended measure, although it is not supported by evidence . Fel d 1 is a “sticky” allergen, and it may take months for symptoms to improve following removal of the cat from the household, particularly if the household is carpeted .…”

Section: Current Managementmentioning

confidence: 99%

“…Environmental control measures are also recommended in order to reduce environmental allergen levels, and measures implemented in cat‐sensitized households may include the following: Excluding the cat from the bedroom Keeping the cat outdoors Use of HEPA filters in vacuums and HVAC systems Removal of carpets Using pillow and mattress covers Removal or covering of upholstered furniture Weekly vacuuming or steam cleaning Wet mopping floors and surfaces Washing walls Ventilation to increase air change rate per hour Changing clothes before moving from an area of high allergen levels to one with lower levels Using nighttime laminar airflow ventilation Regular bathing of cats in the home …”

Section: Current Managementmentioning

confidence: 99%

“…Allergies to cats are the most common mammalian‐origin allergy in humans and affect approximately 1 in 5 adults worldwide . Fel d 1 is the major cat allergen, accounting for up to 96% of human allergic sensitization to cats and 60%‐90% of the overall antigenicity of cats and cat dander …”

Section: Introductionmentioning

confidence: 99%

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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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Background Allergies to cats are the most common animal‐origin allergy, and affect approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals has been increasing, and allergy to cats is a major risk factor for the development of asthma and rhinitis. The diagnosis of cat allergy is now well established. The exact significance of component‐resolved diagnosis in the diagnosis of cat allergy remains to be fully understood. Allergen avoidance is effective but often has a psychologic impact. Allergen immunotherapy is not well demonstrated. There is a need for innovative approaches to better manage cat allergens. Next‐generation care pathways for asthma and rhinitis will define the place of cat allergen avoidance. Methods and Results This manuscript, based on content presented at the European Academy of Allergy and Clinical Immunology Congress 2019, provides information on the prevalence and impact of cat allergies and the molecular biology of Fel d 1, the major cat allergen. Discussion The authors present the scientific basis of a novel care pathway that utilizes anti‐Fel d 1 IgY antibodies to safely and effectively neutralize Fel d 1 after its production by the cat but before human exposure. Conclusion Efficacy of a feline diet with an egg product ingredient containing anti‐Fel d 1 IgY antibodies was demonstrated in vitro, ex vivo, and in vivo, and further validated by a pilot exposure study involving cat‐allergic human participants.

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Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

“…Many owners consider their cats part of the family . For these reasons, allergists' guidelines‐based recommendations to remove the cat from the home are often met with resistance …”

Section: Cat Allergies: a Common Problem With Consequences For Humansmentioning

confidence: 99%

Section: Current Managementmentioning

confidence: 99%

Section: Current Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control

Sparkes

2021

Journal of Feline Medicine and Surgery

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Practical relevance: Human allergy to cats affects a substantial and growing proportion of the global population, and cat allergy is regarded as the third most common cause of human respiratory allergies, and the second most common indoor cause. Veterinarians will frequently encounter owners who are cat-allergic, and having an understanding of this disease and the methods available to help control the allergy will assist them in giving appropriate advice, alongside human healthcare professionals. Aim: The aim of this review is to summarise currently available data on the prevalence, causes, symptoms and control of human allergy to cats. In terms of managing cat allergy, the emphasis is on reviewing current and emerging modalities to reduce environmental exposure to cat allergens rather than on pharmacotherapy or immunotherapy, as it is in these areas in particular that the veterinarian may be able to offer help and advice to complement that of human healthcare professionals. Evidence base: The information in this review is drawn from the current and historical literature on human allergy to cats, and approaches to reduce exposure to cat allergens and manage symptoms of cat allergy.

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Primary and Secondary Environmental Control Measures for Allergic Diseases

Cited by 2 publications

References 235 publications

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control

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