Primary angiosarcoma of the cranial vault: a case report and review of the literature

Chou, Yu-Cheng; Chang, Yuh Lin; Harnod, Tomor; Chen, Wu Fu; Su, Chin Cheng; Lin, Shinn Zong; Hsu, Yung-Hsiang; Yen, Pao-Sheng; Lee, Chau Chin

doi:10.1016/j.surneu.2003.07.002

Cited by 15 publications

(15 citation statements)

References 18 publications

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“…In previous reports of skull angiosarcoma, most cases occurred in the third decade with a marked male predominance [2,12,16].…”

Section: Discussionmentioning

confidence: 89%

“…The skull is an extremely unusual site of occurrence with only 16 cases reported in the literature [11]. Frontal and parietal bones are more commonly involved than the occipital, sphenoid and temporal bones [12,15,16]. Reviewing previous literature, we found only seven cases of temporal bone angiosarcoma [11,13,14,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 97%

“…Unlike extracranial angiosarcomas in which radiation therapy, arsenic exposure and previous trauma have been implicated as predisposing factors, no risk factors were found for primary skull angiosarcomas [11,16]. Skull angiosarcomas are often unicentric tumors although a case of multiple angiosarcoma has been also described [16].…”

Section: Discussionmentioning

confidence: 99%

“…Skull angiosarcomas are often unicentric tumors although a case of multiple angiosarcoma has been also described [16].…”

Section: Discussionmentioning

confidence: 99%

“…The role of adjuvant treatment is not well defmed. Radiotherapy has been given as an adjunct to surgical therapy or as palliative treatment in numerous cases of skull angiosarcoma [13,16,18,19] including three cases of temporal angiosarcoma [13,18,19] but its effectiveness has not been proven yet. In the case we report, radiotherapy was given after surgery because of the important infiltration of the petrous bone by the tumor.…”

Section: Discussionmentioning

confidence: 99%

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Primary temporal bone angiosarcoma: a case report

et al. 2005

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SummaryWe present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a tender swelling above the mastoid. Cranial imaging studies showed a 7 × 5 × 4 cm hypervascularized mass located in the left middle fossa with lysis of the temporal bone and extension to the subcutis. After the baby was delivered by caesarean section, the patient entered the oncology protocol. Selective embolization of the feeding vessels was followed by gross total surgical resection using a combined supra-and infra-tentorial approach. Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features. No extra-cranial tumor was found after extensive staging. The patient received adjuvant radiotherapy followed by a course of chemotherapy consisting of 6 cycles of paclitaxel. At 15 months follow-up, she developed multiple distant metastasis to a left postauricular lymph node and to the lungs and ribs. The patient was given a second line chemotherapy using doxorubicine and ifosfamide. Despite an initial good response, she died with metastatic disease 26 months after diagnosis. We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy.

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“…In previous reports of skull angiosarcoma, most cases occurred in the third decade with a marked male predominance [2,12,16].…”

Section: Discussionmentioning

confidence: 89%