Primary biliary cirrhosis

Richards, Andrea; Rooney, Jane; Prime, Stephen S.; Scully, Crispian

doi:10.1016/s0030-4220(06)80101-5

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…It is commonly concomitant with other disorders, including oral disease. Dry mouth and oral candidiasis are always found in PBC patients 6 , in addition to rampant dental caries 38 . This might imply that there is an imbalance in the oral immune environment in PBC patients.…”

Section: Discussionmentioning

confidence: 99%

Detection of AMA-M2 in human saliva: Potentials in diagnosis and monitoring of primary biliary cholangitis

Hou

et al. 2017

Sci Rep

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Serum anti-mitochondrial antibody type 2 (AMA-M2) is considered as a pivotal biomarker for the diagnosis of primary biliary cholangitis (PBC). However, serological tests have many limitations, including inconvenience, invasiveness, and infection risks. Thus, a less invasive approach to detect AMA-M2 titer is desirable. We examined salivary AMA-M2 of potential PBC patients and found that AMA-M2 could be detected only in saliva of serum AMA-M2-positive PBC patients, but not in saliva of serum AMA-M2-negative PBC patients, oral lichen planus patients (OLP) patients, or healthy controls. Furthermore, the concentration of salivary AMA-M2 was positively correlated with the amount of serum AMA-M2 in patients. The salivary inflammatory cytokines were increased in the PBC, consistent with the results of serum test. These findings indicated that saliva might be a less invasive and cost-effective medium to accurately test for AMA-M2 levels and this is a promising development for the diagnosis and monitoring of PBC.

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Section: Discussionmentioning

confidence: 99%