Primary breast lymphoma: A single‐centre experience

Foo, Marjorie; Lee, Wai Peng; Seah, Chin Mui; Kam, Carmen Jia Wen; Tan, Su-Ming

doi:10.1002/cnr2.1140

Cited by 9 publications

(22 citation statements)

References 26 publications

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“…Regardless of its category, the clinical presentation of BL, which usually includes breast mass with or without enlarged ipsilateral axillary lymph node, is very similar to BC. Previous case series reported a wide variety of histologic subtypes, with the most common ones being DLBCL, MALT lymphoma, and follicular lymphoma 4‐12 . Our study showed similar results with the previous series as DLBCL, MALT lymphoma, and follicular lymphoma constituted in most cases.…”

Section: Discussionsupporting

confidence: 90%

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Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

2021

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Breast lymphoma (BL) is a rare entity representing 1%-2% of breast malignancies while being the most common extra-mammary cancer involving the breast. It primarily affects postmenopausal women with a similar clinical presentation as breast carcinoma. It is classified into two main categories: primary breast lymphoma (PBL), and secondary breast lymphoma (SBL) as part of systemic disease. Bilateral breast involvement is not an uncommon situation and was reported in 0%-25% of patients with PBL in the previous series. Overall, the most common histologic subtype is diffuse large B-cell lymphoma (DLBCL), followed by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and follicular lymphoma. 1,2 The prevalence of a history of breast carcinoma (BC) in patients with BL was not well documented and reported mostly as single case reports. The recommended treatment modality for patients with BL differs from BC and includes chemotherapy ± radiotherapy. When a definitive diagnosis and pathologic subtyping of BL are made on core biopsy, surgery is usually not recommended and has no impact on survival in most cases. A variety of clinical and pathologic characteristics such as age, stage, type of treatment, or pathologic subtype were observed to impact the prognosis of patients with BL. 1,2 However, the significance of history of BC for the prognosis of BL has not been explored in previous studies. In this study, we aimed to report a single health care system experience in BL with a specific focus on patients with a history of BC. | ME THODSAfter obtaining approval from the Northwell Health Institutional Review Board, our health system's pathology database was searched from January 1, 2010, to July 31, 2020, for lymphoid neoplasms involving the breast that were diagnosed on core needle biopsy, excision, mastectomy, or implant removal. Clinical, radiology, and pathology notes were reviewed to note the following: age, sex, history of BC, axillary involvement, side of involvement, radiologic characteristics and size, BIRADS score, type of procedure, pathological

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Section: Discussionsupporting

confidence: 90%

“…ones being DLBCL, MALT lymphoma, and follicular lymphoma. [4][5][6][7][8][9][10][11][12] Our study showed similar results with the previous series as DLBCL, MALT lymphoma, and follicular lymphoma constituted in most cases.…”

Section: Discussionsupporting

confidence: 87%

Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

2021

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“…In view of the mostly indolent clinical behavior of NHL in SS patients, and in consideration of a median follow-up time that rarely exceeds 10 years in most reported studies, an accurate definition of epidemiologic data, including prevalence, can be hardly assessed. In addition, while several studies have reported on the occurrence of NHL in the breast, these were not focused on possible associations between breast NHL and SS [15,[26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

Ingravallo

Maiorano

Moschetta

et al. 2020

JCM

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The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematosus, celiac disease and Sjögren syndrome, and lymphoma, has been widely demonstrated by several epidemiologic studies. By a mechanism which has not yet been entirely elucidated, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to the onset of different types of lymphoma in such patients. Specifically, patients affected by Sjögren syndrome may develop lymphomas many years after the original diagnosis. Several epidemiologic, hematologic, and histological features may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly extranodal marginal zone lymphomas and, less often, diffuse large B-cell, is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma, and predictive factors, still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57-year-old patient. The diagnostic work-up, including radiograms, core needle biopsy, and histological examination, is discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients.

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“…have reported on large case series of (primary and not) breast lymphomas without focusing on such association with SS. [27][28][29][30][31] Nevertheless, although the association between SS (and other autoimmune diseases) and NHL is nowadays well defined, its true biological mechanism has not been fully elucidated yet. [1][2][3][4][5][6][7]10,11,13,27] In an update on prognostic markers of lymphoma development in SS patients, Retamozo et al (2019) [32] stated that such patients show a 7-fold increased risk of lymphoma than systemic lupus erythematosus patients, 4-fold than rheumatoid arthritis patients, and globally >10 folds than the general population.…”

Section: Discussionmentioning

confidence: 99%

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

Ingravallo

Maiorano

Moschetta

et al. 2020

Preprint

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The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematous, celiac disease and Sjögren syndrome, and lymphoma has been widely demonstrated by several epidemiologic studies. By a not yet entirely elucidated mechanism, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to persistent stimulation of both of B- and T-cells, and to the onset of different types of lymphoma in such patients. Specifically, patients affected by may develop lymphomas may years after the original diagnosis. Several epidemiologic, hematologic and histological factors may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly diffuse large B-cell and extranodal marginal zone lymphomas is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma and predictive factors still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57 y.o. patient. The diagnostic work-up, including radiograms, core needle biopsy and histological examination are discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients.

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Primary breast lymphoma: A single‐centre experience

Cited by 9 publications

References 26 publications

Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

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