Primary Breast Osteosarcoma; a case report and review of the literature

Omranipour, Ramesh; Ensani, Fereshteh; Hassanesfahani, Maryam

doi:10.22541/au.162276602.20240137/v1

Cited by 1 publication

(1 citation statement)

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“…The origin of the tumor is uncertain. Researchers approach this tumor similar to a sarcoma (cells originated from totipotent mesenchymal cells of the mammary gland or mesodermal remnants), while Emad A. Rakha showed that almost all POBS are derived from an epithelial origin after being under metaplastic transformation ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

Xue

Shi

2022

Front. Oncol.

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BackgroundPrimary osteosarcoma of the breast (POB) is an extremely aggressive and heterogeneous neoplasm that originates from nonepithelial elements of the mammary gland and accounts for fewer than 1% of breast cancers and fewer than 5% of all sarcomas.Case PresentationAn 83-year-old Chinese woman went to our hospital because of a palpable mass she had had for 8 months in the left breast accompanied by persistent dull pain for 10 days. This mass was initially misdiagnosed as a degenerating fibroadenoma and was graded as probably benign (BI-RADS category 3) by ultrasonography (US) and computed tomography (CT) plain scan and contrast enhancement of chest. Eight months later, it was presumed to be highly malignant and graded as BI-RADS category 4C because of its rapid growth and more calcifications by US and CT. 99mTc-MDP whole-body bone imaging showed that there was a mass-like abnormal radioactive concentration of Tc-99m outside the bone of the left chest. The lumpectomy of the left breast was indicated, and the pathological findings were POB. She succumbed to respiratory failure caused by multiple lung metastases 4 months after the operation.ConclusionPOB is rare, and US and CT cannot reliably distinguish the causes of calcified breast masses between benign and malignant tumors. It can be diagnosed by pathology when metaplastic carcinoma, malignant phyllodes tumor, or carcinosarcoma containing osteoid and bone is excluded. This case could help clinicians to improve the prognosis and treatment of this disease.

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Section: Discussionmentioning

confidence: 99%